Spectrin beta chain, non-erythrocytic 1

BE0004593ProteinHumansSPTBN1

Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane. It is acted on by 2 drugs in DrugBank.

Gene name
SPTBN1
UniProtKB entry
Q01082Swiss-Prot
Cellular location
Cytoplasm, cytoskeleton
Residues / weight
2,364 residues · 274,607 Da
Also known as
Beta-II spectrin · Fodrin beta chain · Spectrin, non-erythroid beta chain 1 · SPTB2

Resolves to

Protein
UniProtQ01082UniProt nameSPTB2_HUMAN
Gene
HGNCHGNC:11275NCBI Gene6711GeneCardsSPTBN1
Pharmacology
KEGGhsa:6711
Structure
PDB1AA2PDB1BKRPDB3EDV
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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13GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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28+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Spectrin beta chain, non-erythrocytic 1, how selective are they, and which programs against it are still in active trials?

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