Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2

BE0004631ProteinHumansHCN2

Hyperpolarization-activated ion channel that is permeable to sodium and potassium ions. It is acted on by 4 drugs in DrugBank.

Gene name
HCN2
UniProtKB entry
Q9UL51Swiss-Prot
Cellular location
Cell membrane
Residues / weight
889 residues · 96,949 Da
Also known as
BCNG-2 · BCNG2 · Brain cyclic nucleotide-gated channel 2

Resolves to

Protein
UniProtQ9UL51UniProt nameHCN2_HUMAN
Gene
HGNCHGNC:4846NCBI Gene610GeneCardsHCN2
Pharmacology
IUPHAR/GtoPdb401KEGGhsa:610
Structure
PDB2MPFPDB3U10
Drugs

What you can answer from here — as of September 07, 2019

4DrugsApproved to experimental, with action, bond type and pharmacological action
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19GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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11+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2, how selective are they, and which programs against it are still in active trials?

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