Small COPII coat GTPase SAR1B

BE0004633ProteinHumansSAR1B

Small GTPase that cycles between an active GTP-bound and an inactive GDP-bound state and mainly functions in vesicle-mediated endoplasmic reticulum (ER) to Golgi transport. It is acted on by 1 drug in DrugBank.

Gene name
SAR1B
UniProtKB entry
Q9Y6B6Swiss-Prot
Cellular location
Endoplasmic reticulum membrane
Residues / weight
198 residues · 22,410 Da
Also known as
3.6.5.2 · GTBPB · GTP-binding protein B · SARA2 · SARB

Resolves to

Protein
UniProtQ9Y6B6UniProt nameSAR1B_HUMAN
Gene
HGNCHGNC:10535NCBI Gene51128GeneCardsSAR1B
Pharmacology
KEGGhsa:51128
Structure
PDB8E0APDB8E0BPDB8E0C
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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19GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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7+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Small COPII coat GTPase SAR1B, and which indications are they being tested in?

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