Solute carrier family 22 member 12

BE0004782ProteinHumansSLC22A12

Electroneutral antiporter that translocates urate across the apical membrane of proximal tubular cells in exchange for monovalent organic or inorganic anions (PubMed:12024214, PubMed:22194875, PubMed:35144162, PubMed:35462902). It is acted on by 16 drugs in DrugBank.

Gene name
SLC22A12
UniProtKB entry
Q96S37Swiss-Prot
Cellular location
Apical cell membrane
Residues / weight
553 residues · 59,630 Da
Also known as
OATL4 · Organic anion transporter 4-like protein · Renal-specific transporter · RST · URAT1

Resolves to

Protein
UniProtQ96S37UniProt nameS22AC_HUMAN
Gene
HGNCHGNC:17989NCBI Gene116085GeneCardsSLC22A12
Pharmacology
IUPHAR/GtoPdb1031KEGGhsa:116085
Structure
PDB8WJGPDB8WJQPDB9B1F
Drugs

What you can answer from here — as of September 07, 2019

16DrugsApproved to experimental, with action, bond type and pharmacological action
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4GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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63+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Solute carrier family 22 member 12, how selective are they, and which programs against it are still in active trials?

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