Corticotropin-releasing hormone receptor 1

BE0008658ProteinHumansCRHR1

G protein-coupled receptor for CRH and UCN stress hormones, which plays a central role in whole body adaptation to stress (PubMed:18292205, PubMed:18801728, PubMed:20966082, PubMed:23576434, PubMed:23863939, PubMed:24290358, PubMed:32004469, PubMed:32004470). It is acted on by 8 drugs in DrugBank.

Gene name
CRHR1
UniProtKB entry
P34998Swiss-Prot
Cellular location
Cell membrane
Residues / weight
415 residues · 47,670 Da
Also known as
Corticotropin-releasing factor receptor 1 · CRF-R-1 · CRF-R1 · CRFR · CRFR-1

Resolves to

Protein
UniProtP34998UniProt nameCRHR1_HUMAN
Gene
HGNCHGNC:2357NCBI Gene1394GeneCardsCRHR1
Pharmacology
IUPHAR/GtoPdb212KEGGhsa:1394
Structure
PDB2L27PDB3EHSPDB3EHT
Drugs

What you can answer from here — as of June 19, 2026

8DrugsApproved to experimental, with action, bond type and pharmacological action
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10GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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44+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Corticotropin-releasing hormone receptor 1, how selective are they, and which programs against it are still in active trials?

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