Polycystin-2-like protein 1
Details
- Name
- Polycystin-2-like protein 1
- Kind
- protein
- Synonyms
- PKD2L
- PKDL
- Polycystic kidney disease 2-like 1 protein
- Polycystin-2 homolog
- Polycystin-2L1
- Polycystin-L
- Polycystin-L1
- TRPP3
- Gene Name
- PKD2L1
- UniProtKB Entry
- Q9P0L9Swiss-Prot
- Organism
- Humans
- NCBI Taxonomy ID
- 9606
- Amino acid sequence
>lcl|BSEQ0049525|Polycystin-2-like protein 1 MNAVGSPEGQELQKLGSGAWDNPAYSGPPSPHGTLRVCTISSTGPLQPQPKKPEDEPQET AYRTQVSSCCLHICQGIRGLWGTTLTENTAENRELYIKTTLRELLVYIVFLVDICLLTYG MTSSSAYYYTKVMSELFLHTPSDTGVSFQAISSMADFWDFAQGPLLDSLYWTKWYNNQSL GHGSHSFIYYENMLLGVPRLRQLKVRNDSCVVHEDFREDILSCYDVYSPDKEEQLPFGPF NGTAWTYHSQDELGGFSHWGRLTSYSGGGYYLDLPGSRQGSAEALRALQEGLWLDRGTRV VFIDFSVYNANINLFCVLRLVVEFPATGGAIPSWQIRTVKLIRYVSNWDFFIVGCEVIFC VFIFYYVVEEILELHIHRLRYLSSIWNILDLVVILLSIVAVGFHIFRTLEVNRLMGKLLQ QPNTYADFEFLAFWQTQYNNMNAVNLFFAWIKIFKYISFNKTMTQLSSTLARCAKDILGF AVMFFIVFFAYAQLGYLLFGTQVENFSTFIKCIFTQFRIILGDFDYNAIDNANRILGPAY FVTYVFFVFFVLLNMFLAIINDTYSEVKEELAGQKDELQLSDLLKQGYNKTLLRLRLRKE RVSDVQKVLQGGEQEIQFEDFTNTLRELGHAEHEITELTATFTKFDRDGNRILDEKEQEK MRQDLEEERVALNTEIEKLGRSIVSSPQGKSGPEAARAGGWVSGEEFYMLTRRVLQLETV LEGVVSQIDAVGSKLKMLERKGWLAPSPGVKEQAIWKHPQPAPAVTPDPWGVQGGQESEV PYKREEEALEERRLSRGEIPTLQRS
- Number of residues
- 805
- Molecular Weight
- 91981.23
- Theoretical pI
- Not Available
- GO Classification
- Functionscalcium-activated cation channel activity / monoatomic cation channel activity / transmembrane transporter bindingProcessesdetection of chemical stimulus involved in sensory perception of taste / inorganic cation transmembrane transport / monoatomic cation transport / protein homotetramerization / response to waterComponentsactin cytoskeleton / cytoplasmic vesicle / cytosol
- General Function
- Pore-forming subunit of a heterotetrameric, non-selective cation channel that is permeable to Ca(2+) (PubMed:10517637, PubMed:11959145, PubMed:23212381, PubMed:25820328, PubMed:27754867, PubMed:29425510, PubMed:30004384). Pore-forming subunit of a calcium-permeant ion channel formed by PKD1L2 and PKD1L1 in primary cilia, where it controls cilium calcium concentration, but does not affect cytoplasmic calcium concentration (PubMed:24336289). The channel formed by PKD1L2 and PKD1L1 in primary cilia regulates sonic hedgehog/SHH signaling and GLI2 transcription (PubMed:24336289). Pore-forming subunit of a channel formed by PKD1L2 and PKD1L3 that contributes to sour taste perception in gustatory cells (PubMed:19812697). The heteromeric channel formed by PKD1L2 and PKD1L3 is activated by low pH, but opens only when the extracellular pH rises again (PubMed:23212381). May play a role in the perception of carbonation taste (By similarity). May play a role in the sensory perception of water, via a mechanism that activates the channel in response to dilution of salivary bicarbonate and changes in salivary pH (By similarity)
- Specific Function
- alpha-actinin binding
- Pfam Domain Function
- Signal Regions
- Not Available
- Transmembrane Regions
- 104-124 357-376 385-405 434-454 480-499 537-557
- Cellular Location
- Cell projection, cilium membrane
- Gene sequence
>lcl|BSEQ0049526|Polycystic kidney disease 2-like 1 protein (PKD2L1) ATGAATGCTGTGGGAAGTCCTGAGGGGCAGGAGCTGCAAAAGCTGGGGAGTGGAGCCTGG GACAACCCCGCCTACAGTGGTCCCCCTTCCCCACACGGGACGCTGAGAGTCTGCACCATC TCCAGCACGGGGCCTCTCCAGCCCCAACCCAAGAAGCCTGAAGATGAACCCCAGGAGACG GCATACAGGACCCAGGTGTCCAGCTGCTGCCTCCATATCTGTCAAGGCATCAGAGGACTT TGGGGAACAACCCTGACTGAGAACACAGCTGAGAACCGGGAACTTTATATCAAGACCACC CTGAGGGAGCTGTTGGTATATATTGTGTTCCTGGTGGACATCTGTCTACTGACCTATGGA ATGACAAGCTCCAGTGCTTATTACTACACCAAAGTGATGTCTGAGCTCTTCTTACATACT CCATCAGACACTGGAGTCTCCTTTCAGGCCATCAGCAGCATGGCGGACTTCTGGGATTTT GCCCAGGGCCCACTACTGGACAGTTTGTATTGGACCAAATGGTACAACAACCAGAGCCTG GGCCATGGCTCCCACTCCTTCATCTACTATGAGAACATGCTGCTGGGGGTTCCGAGGCTG CGGCAGCTAAAGGTCCGCAATGACTCCTGTGTGGTGCATGAAGACTTCCGGGAGGACATT CTGAGCTGCTATGATGTCTACTCTCCAGACAAAGAAGAACAACTCCCCTTTGGGCCCTTC AATGGCACAGCGTGGACATACCACTCGCAGGATGAGTTGGGGGGCTTCTCCCACTGGGGC AGGCTCACAAGCTACAGCGGAGGTGGCTACTACCTGGACCTTCCAGGATCCCGACAGGGT AGTGCAGAGGCTCTCCGGGCCCTTCAGGAGGGGCTGTGGCTGGACAGGGGCACTCGAGTG GTGTTCATCGACTTCTCAGTCTACAATGCCAATATCAATCTTTTCTGTGTCCTGAGGCTG GTGGTGGAGTTTCCAGCTACAGGAGGTGCCATCCCATCCTGGCAAATCCGCACAGTCAAG CTGATCCGCTATGTCAGCAACTGGGACTTCTTTATCGTTGGCTGTGAGGTCATCTTCTGC GTCTTCATCTTCTACTATGTGGTGGAAGAGATCCTGGAGCTCCACATTCACCGGCTTCGC TACCTCAGCAGCATCTGGAACATACTGGACCTGGTGGTCATCTTGCTCTCCATTGTGGCT GTGGGCTTCCACATATTCCGAACCCTCGAGGTGAATCGGCTCATGGGGAAGCTCCTGCAG CAGCCAAACACGTATGCAGACTTTGAGTTCCTCGCCTTCTGGCAGACACAGTACAACAAC ATGAATGCTGTCAACCTCTTCTTCGCCTGGATCAAGATATTCAAGTACATCAGCTTCAAC AAAACCATGACCCAGCTCTCCTCCACGCTGGCCCGCTGTGCCAAGGACATCCTGGGCTTC GCCGTCATGTTCTTCATTGTTTTCTTCGCCTATGCCCAACTCGGCTACCTGCTTTTCGGG ACCCAAGTGGAAAACTTTAGCACTTTCATCAAGTGCATTTTCACTCAGTTCCGGATAATC CTCGGGGACTTTGACTACAATGCTATCGACAATGCCAACCGCATCCTGGGCCCTGCCTAC TTTGTCACCTATGTCTTCTTCGTCTTCTTCGTGCTCCTGAACATGTTCCTGGCCATCATC AATGACACATATTCAGAGGTCAAGGAGGAGCTGGCTGGACAGAAGGATGAGCTGCAACTT TCTGACCTCCTGAAACAGGGCTACAACAAGACCCTACTAAGACTGCGTCTGAGGAAGGAG AGGGTTTCGGATGTGCAGAAGGTCCTGCAGGGTGGGGAGCAGGAGATCCAGTTTGAGGAT TTCACCAACACCTTAAGGGAACTGGGACACGCAGAGCATGAAATCACTGAGCTCACGGCC ACCTTCACCAAGTTTGACAGAGATGGGAATCGTATTCTGGATGAGAAGGAACAGGAAAAA ATGCGACAGGACCTGGAGGAAGAGAGGGTGGCCCTCAACACTGAGATTGAGAAACTAGGC CGATCTATTGTGAGCAGCCCACAAGGCAAATCGGGTCCAGAGGCTGCCAGAGCAGGAGGC TGGGTTTCAGGAGAAGAATTCTACATGCTCACAAGGAGAGTTCTGCAGCTGGAGACTGTC CTGGAAGGAGTAGTGTCCCAGATTGATGCTGTAGGCTCAAAGCTGAAAATGCTGGAGAGG AAGGGGTGGCTGGCTCCCTCCCCAGGCGTGAAGGAACAAGCTATTTGGAAGCACCCGCAG CCAGCCCCAGCTGTGACCCCAGACCCCTGGGGAGTCCAGGGTGGGCAGGAGAGTGAGGTT CCCTATAAAAGAGAAGAGGAAGCCTTAGAGGAGAGGAGACTCTCCCGTGGTGAGATTCCA ACGTTGCAGAGGAGTTAA
- Chromosome Location
- 10
- Locus
- 10q24.31
- External Identifiers
Resource Link UniProtKB ID Q9P0L9 UniProtKB Entry Name PK2L1_HUMAN GeneCard ID PKD2L1 HGNC ID HGNC:9011 PDB ID(s) 3TE3, 4GIF, 6DU8 KEGG ID hsa:9033 IUPHAR/Guide To Pharmacology ID 505 NCBI Gene ID 9033 - General References
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- Guo L, Chen M, Basora N, Zhou J: The human polycystic kidney disease 2-like (PKDL) gene: exon/intron structure and evidence for a novel splicing mechanism. Mamm Genome. 2000 Jan;11(1):46-50. [Article]
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Associated Data
- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details Calcium citrate approved, investigational unknown transporter substrate Details Calcium Phosphate approved unknown transporter substrate Details Calcium phosphate dihydrate approved unknown transporter Details