Polycystin-2-like protein 1

BE0008712ProteinHumansPKD2L1

Homotetrameric, non-selective cation channel that is permeable to sodium, potassium, magnesium and calcium (PubMed:10517637, PubMed:11959145, PubMed:25820328, PubMed:27754867, PubMed:29425510, PubMed:30004384). It is acted on by 3 drugs in DrugBank.

Gene name
PKD2L1
UniProtKB entry
Q9P0L9Swiss-Prot
Cellular location
Cell projection, cilium membrane
Residues / weight
805 residues · 91,981 Da
Also known as
PKD2L · PKDL · Polycystic kidney disease 2-like 1 protein · Polycystin-2 homolog · Polycystin-2L1

Resolves to

Protein
UniProtQ9P0L9UniProt namePK2L1_HUMAN
Gene
HGNCHGNC:9011NCBI Gene9033GeneCardsPKD2L1
Pharmacology
IUPHAR/GtoPdb505KEGGhsa:9033
Structure
PDB3TE3PDB4GIFPDB6DU8
Drugs

What you can answer from here — as of September 03, 2024

3DrugsApproved to experimental, with action, bond type and pharmacological action
Sign in
12GO termsFunction, process and component, as structured annotations
Sign in
3Pfam domainsDomain architecture mapped to Pfam families and clans
Sign in
22+ReferencesStructured and connected to the statements they support
Sign in

Which approved drugs act on Polycystin-2-like protein 1, how selective are they, and which programs against it are still in active trials?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In