Transferrin receptor protein 1

BE0008725ProteinHumansTFRC

Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes (PubMed:26214738, PubMed:41772062). It is acted on by 12 drugs in DrugBank.

Gene name
TFRC
UniProtKB entry
P02786Swiss-Prot
Cellular location
Cell membrane
Residues / weight
760 residues · 84,871 Da
Also known as
p90 · T9 · TfR · TfR1 · TR

Resolves to

Protein
UniProtP02786UniProt nameTFR1_HUMAN
Gene
HGNCHGNC:11763NCBI Gene7037GeneCardsTFRC
Pharmacology
IUPHAR/GtoPdb3196KEGGhsa:7037
Structure
PDB1CX8PDB1DE4PDB1SUV
Drugs

What you can answer from here — as of September 07, 2019

12DrugsApproved to experimental, with action, bond type and pharmacological action
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3Clinical trialsTrials of drugs acting on it, by phase and status
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28GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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55+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Transferrin receptor protein 1, how selective are they, and which programs against it are still in active trials?

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