Cytochrome P450 2C11
Details
- Name
- Cytochrome P450 2C11
- Kind
- protein
- Synonyms
- 1.14.14.1
- Cyp2c
- Cyp2c-11
- CYPIIC11
- Cytochrome P-450(M-1)
- Cytochrome P450-UT-2
- Cytochrome P450-UT-A
- Cytochrome P450H
- Gene Name
- Cyp2c11
- UniProtKB Entry
- P08683Swiss-Prot
- Organism
- Rat
- NCBI Taxonomy ID
- 10116
- Amino acid sequence
>lcl|BSEQ0051630|Cytochrome P450 2C11 MDPVLVLVLTLSSLLLLSLWRQSFGRGKLPPGPTPLPIIGNTLQIYMKDIGQSIKKFSKV YGPIFTLYLGMKPFVVLHGYEAVKEALVDLGEEFSGRGSFPVSERVNKGLGVIFSNGMQW KEIRRFSIMTLRTFGMGKRTIEDRIQEEAQCLVEELRKSKGAPFDPTFILGCAPCNVICS IIFQNRFDYKDPTFLNLMHRFNENFRLFSSPWLQVCNTFPAIIDYFPGSHNQVLKNFFYI KNYVLEKVKEHQESLDKDNPRDFIDCFLNKMEQEKHNPQSEFTLESLVATVTDMFGAGTE TTSTTLRYGLLLLLKHVDVTAKVQEEIERVIGRNRSPCMKDRSQMPYTDAVVHEIQRYID LVPTNLPHLVTRDIKFRNYFIPKGTNVIVSLSSILHDDKEFPNPEKFDPGHFLDERGNFK KSDYFMPFSAGKRICAGEALARTELFLFFTTILQNFNLKSLVDVKDIDTTPAISGFGHLP PFYEACFIPVQRADSLSSHL
- Number of residues
- 500
- Molecular Weight
- 57180.595
- Theoretical pI
- Not Available
- GO Classification
- Functionsarachidonic acid epoxygenase activity / aromatase activity / caffeine oxidase activity / drug binding / heme binding / iron ion binding / monooxygenase activity / oxidoreductase activity / steroid hydroxylase activity / testosterone 16-alpha-hydroxylase activityProcessescellular amide metabolic process / drug catabolic process / drug metabolic process / epoxygenase P450 pathway / exogenous drug catabolic process / hematopoietic progenitor cell differentiation / monocarboxylic acid metabolic process / monoterpenoid metabolic process / oxidation-reduction process / oxidative demethylation / steroid metabolic process / urea metabolic process / xenobiotic metabolic processComponentsendoplasmic reticulum membrane / intracellular membrane-bounded organelle / organelle membrane
- General Function
- A cytochrome P450 monooxygenase involved in the metabolism of steroid hormones and fatty acids. Catalyzes the hydroxylation of carbon-hydrogen bonds. Metabolizes testosterone to 2alpha- and 16alpha-hydroxytestosterone (PubMed:2434473). Catalyzes the epoxidation of double bonds of polyunsaturated fatty acids (PUFAs) (PubMed:10491410, PubMed:15766564). Converts arachidonic acid (ARA, C20:4(n-6)) primarily to epoxyeicosatrienoic acid (EET) regioisomers, 8,9-, 11,12-, and 14,15-EET, with both R,S and S,R stereochemistry (PubMed:10491410). Preferentially produces 11R,12S-EET enantiomer. To a lesser extent, catalyzes the hydroxylation of arachidonic acid producing hydroxyeicosatetraenoates (HETEs) (PubMed:10491410). Metabolizes eicosapentaenoic acid (EPA, C20:5(n-3)) to epoxyeicosatetraenoic acid (EETeTr) regioisomers, 8,9-, 11,12-, 14,15-, and 17,18-EETeTr, preferentially producing 17R,18S-EETeTr enantiomer (PubMed:15766564). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) (PubMed:15766564, PubMed:2434473).
- Specific Function
- arachidonic acid 11,12-epoxygenase activity
- Pfam Domain Function
- p450 (PF00067)
- Signal Regions
- Not Available
- Transmembrane Regions
- Not Available
- Cellular Location
- Endoplasmic reticulum membrane
- Gene sequence
>lcl|BSEQ0051631|Cytochrome P450 2C11 (Cyp2c11) ATGGATCCAGTCCTAGTCCTGGTGCTCACTCTCTCCTCTCTGCTTCTCCTCTCACTCTGG AGACAGAGCTTTGGGAGAGGGAAGCTCCCTCCTGGTCCAACACCTCTCCCAATCATTGGA AACACCCTTCAGATATATATGAAGGACATCGGCCAATCAATAAAAAAGTTTTCAAAAGTC TACGGCCCTATATTTACTCTGTATTTGGGCATGAAGCCCTTTGTGGTGTTGCATGGGTAT GAAGCTGTGAAGGAAGCTCTTGTTGATCTAGGAGAGGAATTTTCTGGAAGAGGCAGTTTT CCAGTATCTGAAAGAGTTAACAAGGGCCTTGGAGTCATTTTTAGCAATGGGATGCAATGG AAGGAGATCCGGCGTTTCTCCATCATGACCCTGAGGACTTTTGGGATGGGCAAGAGGACC ATTGAGGACCGTATTCAAGAGGAGGCTCAGTGCCTTGTGGAGGAACTGAGGAAGAGCAAA GGTGCCCCTTTTGATCCCACCTTTATCCTGGGCTGTGCTCCCTGCAATGTGATATGCTCC ATTATTTTCCAGAATCGCTTTGATTATAAAGATCCGACTTTTCTTAACTTGATGCACAGA TTTAATGAAAACTTCAGGCTTTTCAGCTCCCCATGGCTACAGGTCTGCAATACTTTCCCT GCCATTATTGATTACTTCCCTGGAAGTCATAACCAAGTACTTAAGAATTTCTTCTATATA AAAAACTATGTTTTGGAGAAAGTAAAAGAACACCAAGAGTCCTTGGACAAGGACAATCCT CGGGACTTCATTGATTGTTTCTTGAACAAAATGGAACAGGAAAAGCACAATCCGCAGTCT GAGTTTACCCTTGAAAGCTTGGTGGCTACTGTAACTGACATGTTTGGAGCTGGCACAGAA ACAACAAGTACCACTCTGAGGTATGGACTCCTGCTGCTGCTGAAACACGTGGATGTCACA GCTAAAGTCCAGGAAGAGATAGAACGTGTAATTGGCAGAAACCGGAGCCCCTGCATGAAA GACAGGAGCCAGATGCCCTACACGGATGCTGTAGTGCATGAGATCCAGAGATATATTGAC CTTGTCCCCACAAACCTGCCTCATTTAGTGACACGTGATATAAAATTCAGAAACTACTTC ATTCCCAAGGGTACCAATGTGATAGTATCGCTGTCATCCATACTGCATGATGACAAAGAA TTTCCTAATCCAGAGAAGTTTGACCCTGGTCACTTTCTAGATGAGAGAGGTAACTTTAAG AAGAGTGACTACTTTATGCCATTCTCAGCAGGAAAGAGGATATGTGCAGGAGAAGCCCTG GCTCGCACGGAGCTGTTTTTGTTCTTCACCACCATTTTACAGAATTTTAACCTGAAGTCT CTGGTTGATGTAAAAGACATTGACACAACACCAGCTATCAGTGGATTTGGCCATTTGCCC CCTTTTTACGAGGCTTGTTTTATTCCTGTGCAAAGGGCAGACTCTCTAAGCTCTCATCTG TAA
- Chromosome Location
- 1
- Locus
- 1q53
- External Identifiers
Resource Link UniProtKB ID P08683 UniProtKB Entry Name CP2CB_RAT KEGG ID rno:29277 NCBI Gene ID 29277 - General References
- Yoshioka H, Morohashi K, Sogawa K, Miyata T, Kawajiri K, Hirose T, Inayama S, Fujii-Kuriyama Y, Omura T: Structural analysis and specific expression of microsomal cytochrome P-450(M-1) mRNA in male rat livers. J Biol Chem. 1987 Feb 5;262(4):1706-11. [Article]
- Morishima N, Yoshioka H, Higashi Y, Sogawa K, Fujii-Kuriyama Y: Gene structure of cytochrome P-450(M-1) specifically expressed in male rat liver. Biochemistry. 1987 Dec 15;26(25):8279-85. [Article]
- Strom A, Mode A, Zaphiropoulos P, Nilsson AG, Morgan E, Gustafsson JA: Cloning and pretranslational hormonal regulation of testosterone 16 alpha-hydroxylase (P-45016 alpha) in male rat liver. Acta Endocrinol (Copenh). 1988 Jun;118(2):314-20. [Article]
- Biagini C, Celier C: cDNA-directed expression of two allelic variants of cytochrome P450 2C11 using COS1 and SF21 insect cells. Arch Biochem Biophys. 1996 Feb 15;326(2):298-305. doi: 10.1006/abbi.1996.0079. [Article]
- Zaphiropoulos PG, Mode A, Strom A, Husman B, Andersson G, Gustafsson JA: Sequence and regulation of two growth-hormone-controlled, sex-specific isozymes of cytochrome P-450 in rat liver, P-450(15)beta and P-450(16)alpha. Acta Med Scand Suppl. 1988;723:161-7. [Article]
- Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [Article]
- Strom A, Eguchi H, Mode A, Legraverend C, Tollet P, Stromstedt PE, Gustafsson JA: Characterization of the proximal promoter and two silencer elements in the CYP2C11 gene expressed in rat liver. DNA Cell Biol. 1994 Aug;13(8):805-19. [Article]
- Matsumoto T, Emi Y, Kawabata S, Omura T: Purification and characterization of three male-specific and one female-specific forms of cytochrome P-450 from rat liver microsomes. J Biochem. 1986 Nov;100(5):1359-71. [Article]
Associated Data
- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details Bioallethrin approved, experimental no enzyme substrate Details Dicoumarol approved unknown enzyme inhibitor Details