Serine/threonine-protein kinase PAK 4

BE0009508ProteinHumansPAK4

Serine/threonine-protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell adhesion turnover, cell migration, growth, proliferation or cell survival (PubMed:26598620). It is acted on by 4 drugs in DrugBank.

Gene name
PAK4
UniProtKB entry
O96013Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
591 residues · 64,071 Da
Also known as
2.7.11.1 · KIAA1142 · p21-activated kinase 4 · PAK-4

Resolves to

Protein
UniProtO96013UniProt namePAK4_HUMAN
Gene
HGNCHGNC:16059NCBI Gene10298GeneCardsPAK4
Pharmacology
IUPHAR/GtoPdb2136KEGGhsa:10298
Structure
PDB2BVAPDB2CDZPDB2J0I
Drugs

What you can answer from here — as of September 07, 2019

4DrugsApproved to experimental, with action, bond type and pharmacological action
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1Clinical trialTrials of drugs acting on it, by phase and status
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13GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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38+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Serine/threonine-protein kinase PAK 4, how selective are they, and which programs against it are still in active trials?

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