Neutrophil cytosol factor 1

BE0009983ProteinHumansNCF1

Subunit of the phagocyte NADPH oxidase complex that mediates the transfer of electrons from cytosolic NADPH to O2 to produce the superoxide anion (O2(-)) (PubMed:2547247, PubMed:2550933, PubMed:38355798).

Gene name
NCF1
UniProtKB entry
P14598Swiss-Prot
Cellular location
Cytoplasm, cytosol
Residues / weight
390 residues · 44,681 Da
Also known as
47 kDa autosomal chronic granulomatous disease protein · 47 kDa neutrophil oxidase factor · NCF-1 · NCF-47K · Neutrophil NADPH oxidase factor 1

Resolves to

Protein
UniProtP14598UniProt nameNCF1_HUMAN
Gene
HGNCHGNC:7660NCBI Gene653361GeneCardsNCF1
Pharmacology
KEGGhsa:653361
Structure
PDB1GD5PDB1K4UPDB1KQ6

What you can answer from here — as of May 20, 2020

12GO termsFunction, process and component, as structured annotations
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4Pfam domainsDomain architecture mapped to Pfam families and clans
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28+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Neutrophil cytosol factor 1, and which indications are they being tested in?

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