Neutrophil cytosol factor 1
Details
- Name
- Neutrophil cytosol factor 1
- Kind
- protein
- Synonyms
- 47 kDa autosomal chronic granulomatous disease protein
- 47 kDa neutrophil oxidase factor
- NCF-1
- NCF-47K
- Neutrophil NADPH oxidase factor 1
- Nox organizer 2
- Nox-organizing protein 2
- NOXO2
- p47-phox
- SH3 and PX domain-containing protein 1A
- SH3PXD1A
- Gene Name
- NCF1
- UniProtKB Entry
- P14598Swiss-Prot
- Organism
- Humans
- NCBI Taxonomy ID
- 9606
- Amino acid sequence
>lcl|BSEQ0055917|Neutrophil cytosol factor 1 MGDTFIRHIALLGFEKRFVPSQHYVYMFLVKWQDLSEKVVYRRFTEIYEFHKTLKEMFPI EAGAINPENRIIPHLPAPKWFDGQRAAENRQGTLTEYCSTLMSLPTKISRCPHLLDFFKV RPDDLKLPTDNQTKKPETYLMPKDGKSTATDITGPIILQTYRAIANYEKTSGSEMALSTG DVVEVVEKSESGWWFCQMKAKRGWIPASFLEPLDSPDETEDPEPNYAGEPYVAIKAYTAV EGDEVSLLEGEAVEVIHKLLDGWWVIRKDDVTGYFPSMYLQKSGQDVSQAQRQIKRGAPP RRSSIRNAHSIHQRSRKRLSQDAYRRNSVRFLQQRRRQARPGPQSPGSPLEEERQTQRSK PQPAVPPRPSADLILNRCSESTKRKLASAV
- Number of residues
- 390
- Molecular Weight
- 44681.465
- Theoretical pI
- Not Available
- GO Classification
- Functionselectron transfer activity / superoxide-generating NAD(P)H oxidase activity / superoxide-generating NADPH oxidase activator activityProcessescellular response to cadmium ion / cellular response to glucose stimulus / cellular response to reactive oxygen species / cellular response to testosterone stimulus / positive regulation of DNA-templated transcription / positive regulation of epidermal growth factor-activated receptor activity / positive regulation of JNK cascade / positive regulation of p38MAPK cascade / positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction / reactive oxygen species biosynthetic process / regulation of respiratory burst involved in inflammatory responseComponentscytoplasm / cytoplasmic side of plasma membrane / dendrite / membrane / neuronal cell body / plasma membrane
- General Function
- NCF2, NCF1, and a membrane bound cytochrome b558 are required for activation of the latent NADPH oxidase (necessary for superoxide production)
- Specific Function
- electron transfer activity
- Pfam Domain Function
- Signal Regions
- Not Available
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasm, cytosol
- Gene sequence
>lcl|BSEQ0013349|Neutrophil cytosol factor 1 (NCF1) ATGGGGGACACCTTCATCCGTCACATCGCCCTGCTGGGCTTTGAGAAGCGCTTCGTACCC AGCCAGCACTATGTGTACATGTTCCTGGTGAAATGGCAGGACCTGTCGGAGAAGGTGGTC TACCGGCGCTTCACCGAGATCTACGAGTTCCATAAAACCTTAAAAGAAATGTTCCCTATT GAGGCAGGGGCGATCAATCCAGAGAACAGGATCATCCCCCACCTCCCAGCTCCCAAGTGG TTTGACGGGCAGCGGGCCGCCGAGAACCGCCAGGGCACACTTACCGAGTACTGCAGCACG CTCATGAGCCTGCCCACCAAGATCTCCCGCTGTCCCCACCTCCTCGACTTCTTCAAGGTG CGCCCTGATGACCTCAAGCTCCCCACGGACAACCAGACAAAAAAGCCAGAGACATACTTG ATGCCCAAAGATGGCAAGAGTACCGCGACAGACATCACCGGCCCCATCATCCTGCAGACG TACCGCGCCATTGCCAACTACGAGAAGACCTCGGGCTCCGAGATGGCTCTGTCCACGGGG GACGTGGTGGAGGTCGTAGAGAAGAGCGAGAGCGGTTGGTGGTTCTGTCAGATGAAAGCA AAGCGAGGCTGGATCCCAGCGTCCTTCCTCGAGCCCCTGGACAGTCCTGACGAGACGGAA GACCCTGAGCCCAACTATGCAGGTGAGCCATACGTCGCCATCAAGGCCTACACTGCTGTG GAGGGGGACGAGGTGTCCCTGCTCGAGGGTGAAGCTGTTGAGGTCATTCACAAGCTCCTG GACGGCTGGTGGGTCATCAGGAAAGACGACGTCACAGGCTACTTCCCGTCCATGTACCTG CAAAAGTCAGGGCAAGACGTGTCCCAGGCCCAACGCCAGATCAAGCGGGGGGCGCCGCCC CGCAGGTCGTCCATCCGCAACGCGCACAGCATCCACCAGCGGTCGCGGAAGCGCCTCAGC CAGGACGCCTATCGCCGCAACAGCGTCCGTTTTCTGCAGCAGCGACGCCGCCAGGCGCGG CCGGGACCGCAGAGCCCCGGGAGCCCGCTCGAGGAGGAGCGGCAGACGCAGCGCTCTAAA CCGCAGCCGGCGGTGCCCCCGCGGCCGAGCGCCGACCTCATCCTGAACCGCTGCAGCGAG AGCACCAAGCGGAAGCTGGCGTCTGCCGTCTGA
- Chromosome Location
- 7
- Locus
- 7q11.23
- External Identifiers
Resource Link UniProtKB ID P14598 UniProtKB Entry Name NCF1_HUMAN GeneCard ID NCF1 HGNC ID HGNC:7660 PDB ID(s) 1GD5, 1K4U, 1KQ6, 1NG2, 1O7K, 1OV3, 1UEC, 1W70, 1WLP, 7YXW, 8WEJ KEGG ID hsa:653361 NCBI Gene ID 653361 - General References
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Associated Data
- Drug Relations
- Not Available