Advanced glycation end product-specific receptor

BE0010032ProteinHumansAGER

Cell surface pattern recognition receptor that senses endogenous stress signals with a broad ligand repertoire including advanced glycation end products, S100 proteins, high-mobility group box 1 protein/HMGB1, amyloid beta/APP oligomers, nucleic acids, histones, phospholipids and... It is acted on by 7 drugs in DrugBank.

Gene name
AGER
UniProtKB entry
Q15109Swiss-Prot
Cellular location
Cell membrane
Residues / weight
404 residues · 42,802 Da
Also known as
Advanced glycosylation end product-specific receptor · RAGE · Receptor for advanced glycation end products · Receptor for advanced glycosylation end products

Resolves to

Protein
UniProtQ15109UniProt nameRAGE_HUMAN
Gene
HGNCHGNC:320NCBI Gene177GeneCardsAGER
Pharmacology
IUPHAR/GtoPdb2843KEGGhsa:177
Structure
PDB2E5EPDB2ENSPDB2L7U
Drugs

What you can answer from here — as of June 19, 2026

7DrugsApproved to experimental, with action, bond type and pharmacological action
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1Clinical trialTrials of drugs acting on it, by phase and status
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56GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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30+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Advanced glycation end product-specific receptor, how selective are they, and which programs against it are still in active trials?

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