CX3C chemokine receptor 1

BE0010049ProteinHumansCX3CR1

Receptor for the C-X3-C chemokine fractalkine (CX3CL1) present on many early leukocyte cells; CX3CR1-CX3CL1 signaling exerts distinct functions in different tissue compartments, such as immune response, inflammation, cell adhesion and chemotaxis (PubMed:12055230, PubMed:23125415, PubMed:9390561, PubMed:9782118). It is acted on by 1 drug in DrugBank.

Gene name
CX3CR1
UniProtKB entry
P49238Swiss-Prot
Cellular location
Cell membrane
Residues / weight
355 residues · 40,396 Da
Also known as
Beta chemokine receptor-like 1 · C-X3-C CKR-1 · CMK-BRL-1 · CMK-BRL1 · CMKBRL1

Resolves to

Protein
UniProtP49238UniProt nameCX3C1_HUMAN
Gene
HGNCHGNC:2558NCBI Gene1524GeneCardsCX3CR1
Pharmacology
IUPHAR/GtoPdb74KEGGhsa:1524
Structure
PDB7XBWPDB7XBX
Drugs

What you can answer from here — as of April 01, 2021

1DrugApproved to experimental, with action, bond type and pharmacological action
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12GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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15+ReferencesStructured and connected to the statements they support
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Which compounds in development act on CX3C chemokine receptor 1, and which indications are they being tested in?

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