- Hematologic Agents
- Accession Number
Drugs that act on blood and blood-forming organs and those that affect the hemostatic system.
Drug Drug Description Lepirudin A protein-based direct thrombin inhibitor used as an anticoagulant in patients with heparin-induced thrombocytopenia. Bivalirudin A direct thrombin inhibitor used to treat heparin-induced thrombocytopenia and to prevent thrombosis during percutaneous coronary intervention. Alteplase A recombinant form of human tissue plasminogen activator used in the emergency treatment of myocardial infarction, ischemic stroke, and pulmonary emboli. Reteplase A purified form of human tissue plasminogen activator used in the emergency treatment of myocardial infarction, ischemic stroke, and pulmonary emboli. Erythropoietin A recombinant form of human erythropoietin used to increase differentiation of progenitor cells to red blood cells in the treatment of anemia. Desmopressin A synthetic analog of vasopressin used to reduce renal excretion of water in central diabetes insipidus and nocturia. Vasopressin A peptide hormone used to increase blood pressure in patients with vasodilatory shock who are resistant to fluid and catecholamine therapy. Filgrastim A form of recombinant human granulocyte colony stimulating factor used to induce the production of granulocytes and lower infection risk after myelosuppressive therapy. Folic acid A nutrient used to treat megaloblastic anemia and is found in many supplements. Menadione The primary known function of vitamin K is to assist in the normal clotting of blood, but it may also play a role in normal bone calcification. Hydroxocobalamin A synthetic form of vitamin B12 used to treat vitamin B12 associated disorders and cyanide poisoning. Ticlopidine A platelet aggregation inhibitor used in the prevention of conditions associated with thrombi, such as stroke and transient ischemic attacks (TIA). Milrinone A PDE-III inhibitor with inotropic, lusitropic, and vasodilatory properties used for the short-term treatment of acute decompensated heart failure. Anagrelide A platelet-reducing agent used to treat thrombocythemia, and its related complications, secondary to myeloproliferative neoplasms. Argatroban A synthetic direct thrombin inhibitor used for the prevention and treatment of thrombosis related to heparin use. Tranexamic acid An antifibrinolytic used to reduce or prevent hemorrhagic episodes, especially in the context of hyperfibrinolytic disorders. Warfarin A vitamin K antagonist used to treat venous thromboembolism, pulmonary embolism, thromboembolism with atrial fibrillation, thromboembolism with cardiac valve replacement, and thromboembolic events post myocardial infarction. Clopidogrel An antiplatelet agent used to prevent blood clots in peripheral vascular disease, coronary artery disease, and cerebrovascular disease. Pentoxifylline A methylxanthine derivative used to treat intermittent claudication caused by chronic occlusive arterial disease of the limbs. Acetylsalicylic acid A salicylate used to treat pain, fever, inflammation, migraines, and reducing the risk of major adverse cardiovascular events. Hydroxyurea An antimetabolite used to treat sickle cell anemia crisis. Phylloquinone A fat soluble vitamin used to treat hemorrhagic conditions in infants and coumarin overdoses. Enoxaparin A low molecular weight heparin used for the prophylaxis of deep vein thrombosis and ischemic complications of unstable angina and non-Q-wave myocardial infarction. Rivaroxaban A factor Xa inhibitor used to treat deep vein thrombosis (DVT) and pulmonary embolism (PE). May also be used as thrombosis prophylaxis in specific situations. Apixaban An anticoagulant used for the prophylaxis of stroke and systemic embolism in nonvalvular atrial fibrillation, and deep vein thrombosis(DVT) leading to pulmonary embolism(PE), including in patients after a hip or knee replacement surgery. Dabigatran etexilate An anticoagulant used for the prevention of venous thromboembolic events or stroke in patients with recent elective hip or knee replacement surgery and atrial fibrillation. Vorapaxar A platelet aggregation inhibitor used to reduce thrombotic cardiovascular events in patients with a history of myocardial infarction (MI) or peripheral arterial disease (PAD). Edoxaban A novel oral anticoagulant used for reducing the risk of stroke and systemic embolism (SE) in patients with nonvalvular atrial fibrillation (NVAF). Protamine sulfate A blood factor used when the reversal of the anticoagulant effect of heparin is necessary and for the treatment of heparin overdose. Desirudin Indicated as prophylaxis of deep vein thrombosis for patients undergoing hip replacement surgery. Protocatechualdehyde Also known as protocatechuic aldehyde, protocatechualdehyde is a naturally-occuring phenolic aldehyde that is found in barley, green cavendish bananas, grapevine leaves and root of the herb S. miltiorrhiza . Protocatechualdehyde... Protein C A medication used to treat protein C deficiency leading to purpura fulminans or coumarin-induced skin necrosis. Letaxaban Letaxaban has been used in trials studying the treatment and prevention of Venous Thromboembolism and Acute Coronary Syndrome. Naftazone A naphthoquinone derivative indicated in the treatment of varicose veins, hemorrhoids, and superficial thrombophlebitis. Ticagrelor A P2Y12 platelet inhibitor used in patients with a history of myocardial infarction or with acute coronary syndrome (ACS) to prevent future myocardial infarction, stroke and cardiovascular death. Betrixaban A Factor Xa inhibitor used for prophylaxis of venous thromboembolism in hospitalized patients. Lenograstim A granulocyte colony-stimulating factor indicated in the reduction of duration of neutropenia in bone marrow transplant and cytotoxic chemotherapy, as well as mobilizing hematopoietic stem cells in healthy donors. Voxelotor A drug used to inhibit the polymerization of hemoglobin S, preventing the painful and sometimes lethal vaso-occlusive crises associated with sickle cell disease. Zanubrutinib A kinase inhibitor used to treat mantle cell lymphoma, a type of B-cell non-Hodgkin lymphoma, in adults who previously received therapy. Ferric maltol A complexed iron supplement used to treat iron deficiency in adults. Bisindolylmaleimide VIII Not Available Maritime pine extract A plant extract in nutritional supplements for healthy hair, skin, and nails. Antihemophilic factor human A Factor VIII replacement therapy used to treat hemophilia A. Plasminogen Plasma-derived human plasminogen administered intravenously to treat type 1 plasminogen deficiency (hypoplasminogenemia). Darbepoetin alfa A recombinant form of human erythropoietin used to increase differentiation of progenitor cells to red blood cells in the treatment of anemia. Anistreplase A form of recombinant human tissue plasminogen activator used in the emergency treatment of myocardial infarction and pulmonary emboli. Tenecteplase A modified form of recombinant human tissue plasminogen activator used in the emergency treatment of myocardial infarction and pulmonary emboli. Abciximab A monoclonal anti-glycoprotein IIb/IIIa receptor antibody used to prevent thrombosis during percutaneous coronary intervention. Eptifibatide A peptide-based antagonist for glycoprotein IIb/IIIa used in the medical management of myocardial infarction and as an adjunct to percutaneous coronary intervention. Streptokinase A purified fibrinolytic bacterial protein used to breakdown thrombosis in myocardial infarction, pulmonary embolism, and venous thromboembolism. Becaplermin A recombinant form of human platelet-derived growth factor used to treat ulcers due to diabetic neuropathy in the lower extremities when there is adequate blood supply to the area. Dicoumarol For decreasing blood clotting. Often used along with heparin for treatment of deep vein thrombosis. Ardeparin For prevention of deep vein thrombosis, which may result in pulmonary embolism, following knee surgery. Phenindione For the treatment of pulmonary embolism, cardiomyopathy, atrial fibrillation and flutter, cerebral embolism, mural thrombosis, and thrombophili. Also used for anticoagulant prophylaxis. Aminocaproic acid An antifibrinolytic agent used to induce clotting postoperatively. Fondaparinux An anticoagulant used to prevent venous thromboembolism, to treat deep vein thrombosis, and to improve survival following myocardial infarction. Pentosan polysulfate A sulfated pentosyl polysaccharide used to treat bladder pain and discomfort due to interstitial cystitis. Alprostadil A medication used to treat erectile dysfunction. Tirofiban A platelet aggregation inhibitor used to prevent thrombotic events in non-ST elevated acute coronary syndrome. Phenprocoumon An anticoagulant drug used for the prevention of thrombosis. Edetic acid A chelating agent used to treat mercury and lead toxicity and some blood transfusion dependent anemias. Dipyridamole A phosphodiesterase inhibitor used to prevent postoperative thromboembolic events. Iloprost A synthetic prostacyclin analog indicated to treat pulmonary arterial hypertension (PAH). Heparin An anticoagulant indicated for thromboprophylaxis and to treat thrombosis associated with a variety of conditions such as pulmonary embolism and atrial fibrillation. Cilostazol An antiplatelet agent and vasodilator used for the symptomatic relief of intermittent claudication. Ridogrel Used as an adjunctive therapy to induce thrombolysis in patients suffering acute myocardial infarction. Sevoflurane A inhalation anaesthetic agent used for induction and maintenance of general anesthesia during surgical procedures. Epoprostenol A vasodilator and platelet aggregation inhibitor used for the management of primary pulmonary hypertension and pulmonary hypertension in patients with heart failure. Acenocoumarol An anticoagulant drug used in the prevention of thromboembolic diseases in infarction and transient ischemic attacks, as well as management of deep vein thrombosis and myocardial infarction. 1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine Not Available Resveratrol Being investigated for the treatment of Herpes labialis infections (cold sores). Citric acid An anti-chelation additive used in blood collection tubes and as a flavoring and preservative agent in various cosmetic and pharmaceutical products. Ximelagatran For the treatment of acute deep vein thrombosis. Tesmilifene Intended for the treatment of various forms of cancer. Desmoteplase Investigated for use/treatment in cerebral ischemia and strokes. Defibrotide A mixture of single-stranded oligonucleotides used in the treatment of severe hepatic veno-occlusive disease with renal or pulmonary dysfunction following hematopoietic stem-cell transplantation. Ancrod An anticoagulant purified from the venom of the Malayan pit viper that functions by inactivating circulating plasma fibrinogen. Not currently approved for use or marketed in any country. Beraprost For the treatment of pulmonary hypertension. Fibrinolysin Fibrinolysin assists with the healing of minor burns, superficial wounds, ulcers, surgical wounds, and superficial hematomas. Ibudilast For the treatment of multiple sclerosis, asthma, and cerebrovascular disease. Andrographolide Investigated for use/treatment in ulcerative colitis. Pentaerythritol tetranitrate Used for the treatment of angina pectoris . Prasugrel A P2Y12 platelet inhibitor used to reduce risk of thrombotic cardiovascular events in unstable angina or non-ST-elevation myocardial infarction (NSTEMI), and in patients with STEMI when managed with either primary or delayed PCI. Ferumoxytol An intravenous iron replacement product used to treat iron deficiency anemia (IDA) in patients with chronic kidney disease (CKD), or in patients who are unable to tolerate or who have not responded adequately to oral iron supplementation. Sulodexide A drug used to treat chronic venous ulcers in the legs. Semuloparin Investigated for use/treatment in thrombosis. Idraparinux Investigated for use/treatment in thrombosis, venous thromboembolism, strokes, heart disease, and atrial fibrillation. Cangrelor A P2Y12 platelet receptor antagonist used during percutaneous coronary intervention to reduce the risk for periprocedural myocardial infarction (MI), repeat coronary revascularization, and stent thrombosis (ST). Otamixaban Investigated for use/treatment in thrombosis. Aprotinin A serine protease inhibitor used to reduce the risk for perioperative blood loss and the need for blood transfusion in high-risk patients during cardiopulmonary bypass for coronary artery bypass graft surgery. Danaparoid A heparinoid with anticoagulant and antithrombotic activities used for the treatment of acute episode of Heparin-Induced Thrombocytopenia (HIT), and for prophylaxis in patients with a history of HIT. Dalteparin A low molecular weight heparin used for the prophylaxis of thrombotic events in certain patients and prevent acute cardiac ischemic events in patients with unstable angina and non-Q-wave myocardial infarction. Tinzaparin A low molecular weight heparin used for the treatment of acute symptomatic deep vein thrombosis with or without pulmonary embolism when administered in conjunction with warfarin. GW-813893 Not Available Tranilast For the treatment of bronchial asthma, keloid and hypertrophic scar, and allergic disorders such as asthma, allergic rhinitis and atopic dermatitis. Ferulic acid Not Available Efaproxiral Not Available Ethyl biscoumacetate Ethyl biscoumacetate is a courmarin that is used as an anticoagulant. It has actions similar to those of Warfarin. (From Martindale, The Extra Pharmacopoeia, 30th ed, p226) Nadroparin A low molecular weight heparin used for the prophylaxis of thrombotic events and deep vein thrombosis, and prevent unstable angina and non-Q-wave myocardial infarction. Triflusal A medication related to acetylsalicylic acid with antithrombotic effects used in the treatment of thromboembolic diseases. Icosapent ethyl An ethyl ester of eicosapentaenoic acid (EPA) that reduces synthesis and enhances clearance of triglycerides that is used to treat patients with severe hypertriglyceridemia. Batroxobin No approved indications. Batroxobin is a defibrongenating agent which has been observed to reduce fibrinogen levels and thus reduce clot risk when used intravenously. Carbazochrome Indicated for capillary and parenchymal hemorrhage (trauma, tonsillectomy, during surgery), intestinal bleeding, and thrombocytopenic purpura. Hydroxyethyl Starch A plasma volume substitute used to treat and prevent hypovolemia. Pentastarch A plasma volume expander used as an adjunct in the management of shock due to hemorrhage, surgery, sepsis, burns or other trauma. Sodium citrate An ingredient used for the anticoagulation of whole blood as part of automated apheresis procedures. Dextran A low molecular weight dextran used as an adjunctive treatment of shock or impending shock due to hemorrhage, burns, surgery or other trauma, as well as the prophylaxis of venous thrombosis and pulmonary embolism during high-risk medical procedures. Bemiparin An ultra-low molecular weight heparin (ultra-LMWH) used to prevent thromboembolism following surgery and extracorporeal clotting during dialysis. Reviparin By the FDA, reviparin is indicated for the treatment of deep vein which may lead to pulmonary embolism in pediatric patients. It is also indicated for the long-term treatment of... Parnaparin A low molecular weight heparin (LMWH) used to prevent blood clots, specifically deep vein thrombosis. Certoparin A low molecular weight heparin (LMWH) used to prevent blood clots, specifically deep vein thrombosis. Trapidil Used in the treatment of chronic stable angina . Povidone When in complex with iodine, indicated for inducing antisepsis for prevention of infection in minor cuts, scrapes, and burns. Iron protein succinylate Not Annotated Poliglusam Poliglusam, or chitosan, is a linear polysaccharide consisting of D-glucosamine and N-acetyl-D-glucosamine. Naturally-occuring poliglusam is found in the cell walls of fungi, soil and sediments where it is produced from... Thrombin A coagulation factor used to stop bleeding during surgery. Antithrombin III human An alpha-2-glycoprotein used to prevent thromboembolisms in patients with hereditary antithrombin III deficiency. Ozagrel Ozagrel has been used in trials studying the treatment of Dry Eye Syndromes. Naftopidil Naftopidil has been investigated for the treatment of Disorder of Urinary Stent. Menatetrenone A form of vitamin K2 which is used in the treatment of osteoporosis to stimulate osteogenesis. Sarpogrelate Sarpogrelate has been investigated for the treatment of Diabetes Mellitus, Diabetic Nephropathy, Coronary Artery Disease, and Renal Insufficiency, Chronic. Eplivanserin Eplivanserin has been used in trials studying the treatment of Sleep, Insomnia, Chronic Pain, Fibromyalgia, and Primary Insomnia, among others. Iron isomaltoside 1000 Iron isomaltoside 1000 is under investigation in Iron Deficiency Anaemia. Iron isomaltoside 1000 has been investigated for the treatment and basic science of Anemia, Gastric Cancer, Esophageal Cancer, Chronic Kidney... Luspatercept An erythroid maturation agent used to treat anemia secondary to beta thalassemia in patients requiring regular red blood cell transfusions. Darexaban Darexaban has been used in trials studying the prevention and basic science of Japanese, Caucasian, Thromboembolism, Pharmacodynamics, and Pharmacokinetics, among others. Ifetroban Ifetroban has been used in trials studying the treatment of Skin Diseases, Autoimmune Diseases, Pathologic Processes, Scleroderma, Limited, and Scleroderma, Diffuse, among others. Nitroaspirin Nitroaspirin has been investigated for the treatment of Intermittent Claudication. Ketanserin Ketanserin has been investigated for the treatment of Septic Shock, Severe Sepsis, and Diabetic Foot Ulcer. Indobufen A reversible platelet aggregation inhibitor used to prevent coronary and peripheral artery occlusion. Nafamostat Used as an anticoagulant in patients with disseminative blood vessel coagulation, hemorrhagic lesions, and hemorrhagic tendencies. It prevents blood clot formation during extracorporeal circulation in patients undergoing continuous renal replacement... Monteplase Monteplase has been used in trials studying the treatment of Pulmonary Embolism. Butylphthalide Butylphthalide has been used in trials studying the prevention of Restenosis. Methyl isocyanate Methyl isocyanate has been investigated for the treatment of Nosocomial Pneumonia. Hydroxytyrosol Hydroxytyrosol has been used in trials studying the prevention of Breast Cancer. Higenamine Higenamine is under investigation in clinical trial NCT01451229 (Pharmacokinetics and Pharmacodynamics of Higenamine in Chinese Healthy Subjects). Gabexate A protease inhibitor indicated in the treatment of acute pancreatitis. Ramatroban Ramatroban has been used in trials studying the treatment of Asthma. Aminaphthone A medication that inhibits erythrocyte aggregation in capillaries, improving venous return for the treatment of capillary fragility. Menaquinone 7 Menaquinone 7 is under investigation in clinical trial NCT00402974 (The Effect of Vitamin K Supplementation on Osteocalcin Carboxylation in Healthy Children). Troxerutin Troxerutin has been used in trials studying the treatment of Chronic Venous Insufficiency. Fluindione Fluindione is under investigation for the treatment of Venous Thrombosis, Pulmonary Embolism, Permanent Atrial Fibrillation, and Anticoagulating Treatment on a Duration at Least 12-month-old Superior. Fluindione has been investigated for... Protein S human A medication used for emergency reversal of coagulation factor deficiency in vitamin K antagonist therapy. Anti-inhibitor coagulant complex A medication used to control bleeding episodes and prevent bleeding episodes in hemophilia A and B. Kallidinogenase Not Annotated Brinase Not Annotated Picotamide A platelet aggregation inhibitor indicated in the treatment of myocardial infarction, thrombosis, cerebrovascular disorders, pulmonary emboli, and atherosclerosis. Cloricromen Not Annotated Adrenalone Not Annotated Linsidomine Not Annotated Ornipressin Not Annotated Etamsylate A hemostatic agent that acts by restoring capillary resistance and improving platelet adhesion. Dobesilic acid A medication indicated in the treatment of hemorrhoids, venous insufficiency, and other microangiopathies. Oxidized cellulose Not Annotated Melagatran Not Annotated Saruplase Not Annotated Protamine A heparin antagonist indicated in the treatment of heparin overdoses, to counteract heparins preoperatively, or during cardiac surgery and dialysis. Cetiedil Not Annotated Ferric subsulfate Ferric subsulfate is a stypic or hemostatic agent that causes agglutination of surface proteins resulting in local hemostasis. It has the chemical formula Fe4(OH)2(SO4)5. It is used after superficial skin... Bismuth subgallate A medication used to deodorize flatulence and stools as well as hemostasis in soft tissue surgery. Relcovaptan Not Annotated Plasma protein fraction (human) A plasma protein solution used to treat coagulation factor deficiencies, reverse anticoagulant effects, and shock from a loss of plasma fluids, and is also used in plasma exchange procedures. Tocopherylquinone Not Annotated Beroctocog alfa Beroctocog alfa is indicated for the prevention and control of bleeding in patients with hemophilia A or acquired Factor VIII (FVIII) deficiency. It is also indicated for surgical/invasive procedures in... Ferrous gluconate A medication used to treat iron-deficiency anemia. Ferrous succinate An iron supplement indicated in the treatment of iron deficiency anemia. Potassium triiodide Not Annotated Edetate calcium disodium anhydrous A chelating agent used to treat lead poisoning. Lypressin Not Annotated Dabigatran Dabigatran is the active form of the orally bioavailable prodrug dabigatran etexilate. Menaquinone 6 Menaquinone 6 is under investigation in clinical trial NCT01194778 (Comparison of Efficacy of Different Dosages Vitamin K2). Menaquinone Menaquinone is under investigation in clinical trial NCT01533441 (Vitamin K2 Intervention in Patients With Vitamin K Antagonists). Iron polymaltose Not Annotated Polygeline A medication used for plasma volume expansion. Dermatan sulfate A medication indicated to prevent deep vein thrombosis. Menadione bisulfite Not Annotated Carbazochrome sulfonic acid A hemostatic agent indicated to treat bleeding in capillary fragility. Rurioctocog alfa pegol A pegylated recombinant human coagulation factor VIII used to treat and prevent bleeding episodes in patients 12 years and above with hemophilia A. Glenzocimab Not Annotated
- Drugs & Drug Targets