Peptide Hormones

Name
Peptide Hormones
Accession Number
DBCAT000055
Description

Hormones synthesized from amino acids. They are distinguished from INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS in that their actions are systemic.

Drugs
DrugDrug Description
LeuprolideA peptide-based GnRH receptor superagonist used for the palliative treatment of prostate cancer, uterine leiomyomata, endometriosis, and central precocious puberty.
SermorelinFor the treatment of dwarfism, prevention of HIV-induced weight loss
GoserelinA synthetic analog of luteinizing hormone-releasing hormone used to treat breast cancer and prostate cancer by reducing secretion of gonadotropins from the pituitary.
Salmon calcitoninA synthetic peptide form of calcitonin used to inhibit bone resorption in the treatment of hypercalcemia, osteoporosis, and Paget's disease.
Thyrotropin alfaA recombinant form of thyroid stimulating hormone used in diagnostic testing for thyroid cancer and alongside radioactive agents to destroy thyroid tissue.
Insulin humanA recombinant form of human insulin used to control hyperglycemia in diabetes mellitus.
MenotropinsA purified combination of human luteinizing hormone and follicle stimulating hormone used to treat female infertility.
DesmopressinA synthetic analog of vasopressin used to reduce renal excretion of water in central diabetes insipidus and nocturia.
GlucagonA form of recombinant glucagon used to treat hypoglycemia in diabetes mellitus and as a part of gastrointestinal imaging procedures.
Insulin lisproA modified form of fast-acting insulin used to control hyperglycemia in diabetes mellitus.
Insulin glargineA modified form of long-acting or basal insulin used to control hyperglycemia in diabetes mellitus.
CetrorelixA synthetic peptide antagonist of gonadotropin releasing hormone used to prevent luteinizing hormone surges in women undergoing assisted reproduction therapy.
SomatotropinA form of recombinant human growth hormone used to treat dwarfism, growth hormone deficiency, and acromegaly as well as to prevent weight loss in HIV patients.
FollitropinA form of recombinant human follicle stimulating hormone used to stimulate follicle development in women with primary ovarian hypogonadism and in men with hypogonadotropic hypogonadism.
VasopressinA peptide hormone used to increase blood pressure in patients with vasodilatory shock who are resistant to fluid and catecholamine therapy.
Insulin porkA purified form of porcine insulin used to control hyperglycemia in diabetes mellitus.
PegvisomantA growth hormone receptor antagonist used to treat acromegaly.
FelypressinFor use as an alternative to adrenaline as a localising agent, provided that local ischaemia is not essential.
UrofollitropinA form of purified human follicle stimulating hormone used to treat infertility in females by inducing follicle development in women without primary ovarian failure.
OxytocinA recombinant hormone used to induce or strengthen uterine contractions in pregnant women to aid in labor and delivery or to control postpartum bleeding.
PentagastrinA gastrin-like molecule used as a diagnostic aid for the evaluation of gastric acid secretory function, gastric hypersecretion, and Zollinger-Ellison tumors.
GonadorelinA synthetic GnRH used to test the function of gonadotropes and the pituitary.
NafarelinA gonadotropin releasing hormone agonist used to treat central precocious puberty.
PramlintideAn amylin analog used for the management of type 1 and type 2 diabetes mellitus as an adjunct to preprandial insulin therapy in patients without adequate glycemic control of insulin therapy.
CarbetocinAn oxytocin agent used to control postpartum hemorrhage and bleeding after giving birth.
TetracosactideA diagnostic agent used in the screening of patients presumed to have adrenocortical insufficiency.
CorticotropinA diagnostic agent used in the screening of patients presumed to have adrenocortical insufficiency.
Insulin aspartA rapid-acting form of insulin used for glycemic control in type 1 and type 2 diabetes mellitus.
Insulin detemirA long-acting form of insulin used for glycemic control in type 1 and type 2 diabetes mellitus.
Insulin glulisineA short-acting form of insulin used for glycemic control in type 1 and type 2 diabetes mellitus.
TerlipressinCommonly used to stop bleeding of varices in the food pipe (oesophagus).
VapreotideFor the treatment of esophageal variceal bleeding in patients with cirrhotic liver disease and has also shown efficacy in the treatment of patients with AIDS-related diarrhea.
NesiritideA recombinant natriuretic peptide used for the treatment of patients with acutely decompensated congestive heart failure who have dyspnea at rest or with minimal activity.
ThymalfasinIndicated as an adjuvant for influenza vaccine in elderly patients and as an adjuvant for both influenza and hepatitis B vaccines in chronic hemodialysis patients who failed to achieve adequate...
G17DTIntended for the treatment of various forms of cancer.
AfamelanotideAn injectable subcutaneous implant used to mitigate phototoxicity secondary to erythropoietic protoporphyria (EPP).
UlaritideInvestigated for use/treatment in congestive heart failure.
AbaloparatideA parathyroid hormone-related protein (PTHrP) analog used for the treatment of osteoporosis in postmenopausal women with a high risk of fracture.
LeptinInvestigated for use/treatment in lipodystrophy and obesity.
NN344Investigated for use/treatment in diabetes mellitus type 1 and 2.
CorticorelinInvestigated for use/treatment in brain cancer and neurologic disorders.
NBI-6024Investigated for use/treatment in diabetes mellitus type 1 and pediatric indications.
Parathyroid hormoneAn analog of human parathyroid hormone (PTH) used to treat hypocalcemia caused by hypoparathyroidism.
AviptadilNot Annotated
TeriparatideA recombinant parathyroid hormone used for the treatment of osteoporosis.
AnamorelinInvestigated for use/treatment in cachexia and anorexia.
LiraglutideA GLP-1 analog used in the management of type 2 diabetes mellitus and prevention of cardiovascular complications associated with diabetes.
PasireotideA somatostatin analog used in the treatment of Cushing’s disease, specifically for those patients whom pituitary surgery is not appropriate.
BuserelinA LHRH agonist used for the palliative treatment of hormone-dependent advanced carcinoma of the prostate gland in males and treatment of endometriosis in females.
SaralasinNot Annotated
GanirelixA GnRH antagonist used in assisted reproduction in women undergoing controlled ovarian hyperstimulation to control ovulation by inhibiting the premature LH surges.
HistrelinA GnRH agonist found in subcutaneous implants used for the treatment of pediatric patients with central precocious puberty and the palliative treatment of advanced prostate cancer.
LanreotideA somatostatin analog used for the treatment of unresectable, well- or moderately-differentiated, locally advanced or metastatic gastroenteropancreatic neuroendocrine tumors and acromegaly.
TriptorelinA GnRH agonist indicated for the palliative treatment of advanced prostate cancer.
TesamorelinA growth hormone releasing factor (GRF) analog used to reduce excessive abdominal fat in HIV patients who have developed lipodystrophy.
TeduglutideA glucagon-like peptide-2 (GLP-2) analog used to treat patients with Short Bowel Syndrome (SBS) who require parenteral nutritional support.
AlbiglutideA GLP-1 agonist used to manage type 2 diabetes mellitus.
DulaglutideA GLP-1 agonist used to manage type 2 diabetes mellitus.
MetreleptinA leptin analogue used as an adjunct to diet as replacement therapy to treat the complications of leptin deficiency in patients with congenital or acquired generalized lipodystrophy.
AtosibanAn inhibitor of oxytocin and vasopressin used to delay imminent preterm birth in pregnant adult women displaying specific clinical observations.
Corifollitropin alfaA FSH analogue indicated for Controlled Ovarian Stimulation (COS) in combination with a GnRH antagonist for the development of multiple follicles in women participating in an Assisted Reproductive Technology (ART) program.
Corticorelin ovine triflutateA synthetic corticotropin-releasing hormone used for diagnostic purposes in differentiating pituitary and ectopic production of ACTH in patients with ACTH-dependent Cushing's syndrome.
SomatremA recombinant growth hormone used to treat adult growth hormone deficiency and treat disrupted growth in children due to growth hormone insufficiency or deficiency, turner's syndrome, chronic renal failure, and small stature for gestational age.
SomatostatinA naturally-occurring peptide hormone used for the symptomatic treatment of acute bleeding from esophageal varices.
Chorionic Gonadotropin (Human)A naturally-occurring hormone produced during human placenta used for the treatment of prepubertal cryptorchidism and hypogonadotropic hypogonadism in selected males, and induction of pregnancy in selected infertile women.
ProtirelinA synthetic analogue of thyrotropin-releasing hormone that has been used during diagnostic tests to evaluate function of the thyroid gland.
Secretin porcineA secretin hormone used to stimulate pancreatic or gastric secretions to diagnose exocrine pancreas dysfunction, gastrinoma, and abnormalities in the bile and pancreatic ducts.
Insulin degludecA long acting insulin used to treat hyperglycemia caused by type 1 and 2 diabetes mellitus.
DeslorelinDeslorelin acetate is an injectable gonadotropin releasing hormone super-agonist also known as an LHRH agonist. It stops the production of sex hormones.
Insulin peglisproNot Annotated
BremelanotideBremelanotide is indicated to treat premenopausal women with hypoactive sexual desire disorder that is not due to a medical or psychiatric condition, problems with the relationship, or the effects of...
SetmelanotideSetmelanotide has been investigated for the treatment of obesity.
BombesinBombesin is under investigation in clinical trial NCT01205321 (PET/CT Imaging for Radiation Dosimetry, Plasma Pharmacokinetics, Biodistribution, Safety and Tolerability and Diagnostic Performance of BAY86-7548 in Patients With Prostate Cancer and...
CenderitideCenderitide is under investigation for the treatment of ST Elevation (STEMI) Myocardial Infarction of Anterior Wall.
Angiotensin IIA peptide hormone of the RAAS system used to raise blood pressure in septic or other forms of shock.
LenomorelinLenomorelin has been investigated for the treatment and basic science of Cancer, Alcoholism, Metabolism, Hypopituitarism, and Frailty Syndrome, among others.
VosoritideVosoritide has been used in trials studying the treatment of Achondroplasia.
Thymosin beta-4Thymosin Beta 4 has been investigated for the treatment of STEMI, Dry Eye, Diabetes, Pressure Ulcers, and Dry Eye Syndrome, among others.
TT-232Tln 232 is under investigation in clinical trial NCT00422786 (Phase II Study of CAP-232 in Patients With Refractory Metastatic Renal Cell Carcinoma).
SelepressinSelepressin has been used in trials studying the treatment of Septic Shock.
PentetreotidePentetreotide has been used in trials studying the diagnostic of cushing syndrome.
Zoptarelin doxorubicinZoptarelin doxorubicin has been used in trials studying the treatment of Breast Cancer, Ovarian Cancer, Prostate Cancer, Endometrial Cancer, and Urothelial Carcinoma, among others.
SomatoprimSomatoprim is under investigation for the treatment of Acromegaly.
Pancreatic PolypeptidePancreatic Polypeptide has been investigated for the treatment of Diabetes Mellitus, Type 1.
Urocortin-2Urocortin 2 has been investigated for the basic science of Heart Failure and Cardiovascular Disease.
AlsactideNot Annotated
OrnipressinNot Annotated
AngiotensinamideNot Annotated
ElcatoninNot Annotated
DemoxytocinNot Annotated
SemaglutideA glucagon-like peptide 1 receptor agonist used to improve glycemic control in type 2 diabetes mellitus.
TaspoglutideTaspoglutide is a pharmaceutical drug, a glucagon-like peptide-1 agonist (GLP-1 agonist), under investigation for treatment of type 2 diabetes being codeveloped by Ipsen and Roche. In September 2010 Roche halted...
Secretin humanA secretin hormone used to stimulate pancreatic or gastric secretions to diagnose exocrine pancreas dysfunction, gastrinoma, and abnormalities in the bile and pancreatic ducts.
LypressinNot Annotated
Indium In-111 pentetreotideIndium In 111 pentetreotide (Octreoscan) has been used in trials studying the diagnostic of SARCOIDOSIS, Solid Tumors, and cushing syndrome.
PlecanatideA laxative used to treat chronic idiopathic constipation and IBS with constipation.
Peptide YY (3-36)Investigated for use/treatment in metabolic disease and obesity.
Luteinizing hormoneNot Annotated
ProcalcitoninProcalcitonin is under investigation in clinical trial NCT03440060 (Procalcitonin-guided Antibiotic Therapy During Severe Exacerbation of COPD).
SomapacitanA human growth hormone analog subcutaneous injection indicated for adults with growth hormone deficiency.
Somatropin pegolSomatropin pegol is under investigation in clinical trial NCT00715689 (Dose Study in Growth Hormone Deficient Adults Investigating Safety, Pharmacokinetics and Pharmacodynamics of NNC126-0083).
Gastric inhibitory polypeptideGastric inhibitory polypeptide is under investigation in clinical trial NCT03081676 (The Effect of GIP and GLP-1 on Insulin and Glucagon Secretion in Patients With HNF1A-diabetes Treated With or Without Sulphonylurea).
ThyrotropinThyrotropin is under investigation in clinical trial NCT01348191 (Detection of Thyrotrophin Receptor in Human Myometrium).
rGLP-1Investigated for use/treatment in congestive heart failure and diabetes mellitus type 2.
Angiotensin 1-7TXA127 has been investigated for the treatment of Miscellaneous Peripheral Blood Cell Abnormalities.
AclerastideAclerastide has been investigated for the treatment of Diabetic Foot, Diabetic Foot Ulcers, and Foot Ulcer, Diabetic.
PirnabinePirnabine has been used in trials studying the treatment of Chronic Idiopathic Constipation.
AlbusomatropinAlbusomatropin has been used in trials studying the treatment of Growth Hormone-Deficiency and Growth Hormone Deficiency.
BPI-3016BPI-3016 is under investigation in clinical trial NCT03188848 (Dose Escalating Study of BPI-3016 in Healthy Subjects).
TirzepatideTirzepatide is under investigation in clinical trial NCT03311724 (A Study of Tirzepatide (LY3298176) in Participants With Type 2 Diabetes).
Atrial natriuretic peptideNot Annotated
Drugs & Drug Targets
DrugTargetType
LeuprolideGonadotropin-releasing hormone receptortarget
SermorelinGrowth hormone-releasing hormone receptortarget
GoserelinLutropin-choriogonadotropic hormone receptortarget
GoserelinGonadotropin-releasing hormone receptortarget
Salmon calcitoninCalcitonin receptortarget
Thyrotropin alfaThyrotropin receptortarget
Insulin humanInsulin receptortarget
Insulin humanRetinoblastoma-associated proteintarget
Insulin humanInsulin-like growth factor 1 receptortarget
Insulin humanInsulin-degrading enzymeenzyme
Insulin humanNeuroendocrine convertase 2enzyme
Insulin humanNeuroendocrine convertase 1enzyme
Insulin humanCytochrome P450 1A2enzyme
Insulin humanCarboxypeptidase Etarget
MenotropinsFollicle-stimulating hormone receptortarget
MenotropinsLutropin-choriogonadotropic hormone receptortarget
DesmopressinVasopressin V1a receptortarget
DesmopressinVasopressin V1b receptortarget
DesmopressinVasopressin V2 receptortarget
DesmopressinProstaglandin G/H synthase 1enzyme
DesmopressinProstaglandin G/H synthase 2enzyme
GlucagonGlucagon receptortarget
GlucagonGlucagon-like peptide 2 receptortarget
GlucagonGlucagon-like peptide 1 receptortarget
Insulin lisproInsulin receptortarget
Insulin lisproInsulin-like growth factor 1 receptortarget
Insulin lisproCytochrome P450 1A2enzyme
Insulin glargineInsulin receptortarget
Insulin glargineInsulin-like growth factor 1 receptortarget
Insulin glargineCytochrome P450 1A2enzyme
CetrorelixLutropin-choriogonadotropic hormone receptortarget
CetrorelixGonadotropin-releasing hormone receptortarget
SomatotropinGrowth hormone receptortarget
SomatotropinProlactin receptortarget
FollitropinFollicle-stimulating hormone receptortarget
VasopressinVasopressin V1a receptortarget
VasopressinVasopressin V2 receptortarget
VasopressinVasopressin V1b receptortarget
VasopressinCanalicular multispecific organic anion transporter 1transporter
Insulin porkInsulin receptortarget
Insulin porkHLA class II histocompatibility antigen, DQ alpha 2 chaintarget
Insulin porkHLA class II histocompatibility antigen, DQ beta 1 chaintarget
Insulin porkRetinoblastoma-associated proteintarget
Insulin porkCathepsin Dtarget
Insulin porkInsulin-like growth factor 1 receptortarget
Insulin porkInsulin-degrading enzymetarget
Insulin porkNeuroendocrine convertase 2target
Insulin porkCarboxypeptidase Etarget
Insulin porkNeuroendocrine convertase 1target
Insulin porkProtein NOV homologtarget
Insulin porkLow-density lipoprotein receptor-related protein 2target
Insulin porkInsulin-like growth factor-binding protein 7target
Insulin porkSynaptotagmin-like protein 4target
Insulin porkCytochrome P450 1A2enzyme
PegvisomantGrowth hormone receptortarget
PegvisomantSterol 26-hydroxylase, mitochondrialenzyme
PegvisomantGlutamine synthetaseenzyme
PegvisomantCytochrome P450 2C18enzyme
PegvisomantCytochrome P450 3A4enzyme
PegvisomantCholinesteraseenzyme
PegvisomantCytochrome P450 4A11enzyme
FelypressinVasopressin V1a receptortarget
UrofollitropinFollicle-stimulating hormone receptortarget
OxytocinOxytocin-neurophysin 1target
OxytocinOxytocin receptortarget
OxytocinProlyl endopeptidaseenzyme
PentagastrinGastrin/cholecystokinin type B receptortarget
PentagastrinCholinesteraseenzyme
GonadorelinGonadotropin-releasing hormone receptortarget
GonadorelinPutative gonadotropin-releasing hormone II receptortarget
NafarelinGonadotropin-releasing hormone receptortarget
NafarelinPutative gonadotropin-releasing hormone II receptortarget
PramlintideReceptor activity-modifying protein 1target
PramlintideReceptor activity-modifying protein 2target
PramlintideReceptor activity-modifying protein 3target
PramlintideCalcitonin receptortarget
CarbetocinOxytocin receptortarget
TetracosactideAdrenocorticotropic hormone receptortarget
CorticotropinAdrenocorticotropic hormone receptortarget
CorticotropinCorticoliberintarget
Corticotropin3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2enzyme
Corticotropin25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrialenzyme
Corticotropin1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrialenzyme
CorticotropinCytochrome P450 3A4enzyme
Insulin aspartInsulin receptortarget
Insulin aspartInsulin-like growth factor 1 receptortarget
Insulin aspartCytochrome P450 1A2enzyme
Insulin detemirInsulin receptortarget
Insulin detemirSerum albumincarrier
Insulin detemirInsulin-like growth factor 1 receptortarget
Insulin detemirCytochrome P450 1A2enzyme
Insulin glulisineInsulin receptortarget
Insulin glulisineInsulin-like growth factor 1 receptortarget
Insulin glulisineCytochrome P450 1A2enzyme
TerlipressinVasopressin V1a receptortarget
TerlipressinVasopressin V2 receptortarget
TerlipressinVasopressin V1b receptortarget
VapreotideNeurokinin 1 receptortarget
VapreotideSomatostatin receptor type 2target
VapreotideSomatostatin receptor type 5target
VapreotideCytochrome P450 3A4enzyme
NesiritideAtrial natriuretic peptide receptor 1target
NesiritideAtrial natriuretic peptide receptor 2target
NesiritideAtrial natriuretic peptide receptor 3target
AfamelanotideMelanocyte-stimulating hormone receptortarget
UlaritideAtrial natriuretic peptide receptor 1target
AbaloparatideParathyroid hormone/parathyroid hormone-related peptide receptortarget
LeptinLeptin receptortarget
NN344Insulin receptortarget
NN344Cytochrome P450 1A2enzyme
CorticorelinDopamine beta-hydroxylaseenzyme
Parathyroid hormoneParathyroid hormone/parathyroid hormone-related peptide receptortarget
Parathyroid hormoneParathyroid hormone 2 receptortarget
TeriparatideParathyroid hormone/parathyroid hormone-related peptide receptortarget
LiraglutideGlucagon-like peptide 1 receptortarget
LiraglutideDipeptidyl peptidase 4enzyme
LiraglutideNeprilysinenzyme
LiraglutideSerum albumincarrier
PasireotideSomatostatin receptor type 1target
PasireotideSomatostatin receptor type 2target
PasireotideSomatostatin receptor type 3target
PasireotideSomatostatin receptor type 5target
PasireotideCytochrome P450 3A4enzyme
BuserelinLutropin-choriogonadotropic hormone receptortarget
BuserelinGonadotropin-releasing hormone receptortarget
BuserelinCytochrome P450 19A1enzyme
GanirelixGonadotropin-releasing hormone receptortarget
HistrelinGonadotropin-releasing hormone receptortarget
LanreotideSomatostatin receptor type 2target
LanreotideSomatostatin receptor type 5target
LanreotideCytochrome P450 3A4enzyme
TriptorelinGonadotropin-releasing hormone receptortarget
TesamorelinGrowth hormone-releasing hormone receptortarget
TeduglutideGlucagon-like peptide 2 receptortarget
AlbiglutideGlucagon-like peptide 1 receptortarget
DulaglutideGlucagon-like peptide 1 receptortarget
MetreleptinLeptin receptortarget
AtosibanOxytocin receptortarget
AtosibanVasopressin V1a receptortarget
AtosibanVasopressin V1b receptortarget
AtosibanVasopressin V2 receptortarget
Corifollitropin alfaFollicle-stimulating hormone receptortarget
Corticorelin ovine triflutateCorticotropin-releasing factor receptor 1target
SomatremGrowth hormone receptortarget
SomatremInsulin-like growth factor 1 receptortarget
SomatostatinSomatostatin receptor type 1target
SomatostatinSomatostatin receptor type 2target
SomatostatinSomatostatin receptor type 3target
SomatostatinSomatostatin receptor type 4target
SomatostatinSomatostatin receptor type 5target
SomatostatinP-glycoprotein 1transporter
SomatostatinCytochrome P450 3A4enzyme
Chorionic Gonadotropin (Human)Lutropin-choriogonadotropic hormone receptortarget
ProtirelinThyrotropin Releasing Hormone Receptortarget
Insulin degludecInsulin receptortarget
Insulin degludecInsulin-like growth factor 1 receptortarget
Insulin degludecSerum albumincarrier
Insulin degludecCytochrome P450 1A2enzyme
Insulin peglisproCytochrome P450 1A2enzyme
BremelanotideMelanocyte-stimulating hormone receptortarget
BremelanotideMelanocortin receptor 4target
BremelanotideMelanocortin receptor 3target
BremelanotideMelanocortin receptor 5target
BremelanotideAdrenocorticotropic hormone receptortarget
Angiotensin IIType-1 angiotensin II receptortarget
SemaglutideSerum albumincarrier
SemaglutideDipeptidyl peptidase 4enzyme
SemaglutideNeprilysinenzyme
SemaglutideGlucagon-like peptide 1 receptortarget
SemaglutideLipoprotein lipaseenzyme
SemaglutideAlpha-amylase 1enzyme
Secretin humanSecretin receptortarget
LypressinVasopressin V1a receptortarget
LypressinVasopressin V2 receptortarget
LypressinVasopressin V1b receptortarget
LypressinCanalicular multispecific organic anion transporter 1transporter
PlecanatideGuanylate cyclase soluble subunit alpha-2target
Peptide YY (3-36)Neuropeptide Y receptor type 2target
Peptide YY (3-36)Neuropeptide Y receptor type 1target
Peptide YY (3-36)Neuropeptide Y receptor type 5target
Peptide YY (3-36)Neuropeptide Y receptor type 4target
SomapacitanCorticosteroid 11-beta-dehydrogenase isozyme 1enzyme
SomapacitanCytochrome P450 2C12, female-specificenzyme
SomapacitanCytochrome P450 1A2enzyme
SomapacitanCytochrome P450 2C19enzyme
SomapacitanSerum albumincarrier
SomapacitanGrowth hormone receptortarget