AOD9604

DB06388ExperimentalSmall molecule

AOD9604 is a synthetic analogue of the lipolytic domain of human growth hormone, being investigated for the treatment of obesity.

Mechanism: AOD9604 is a 16-amino acid, orally active peptide modelled on one fragment of the human Growth Hormone molecule. Studies suggest that AOD9604 retains the bone stimulating properties of human Growth Hormone. AOD9604 indicates that this drug may have a role in the prevention and possible treatment of osteoporosis, through direct action on osteoblasts, the cells which build new bone.
Curator reviewed
Primary indication: Investigated for use/treatment in obesity and osteoporosis.Curator reviewed
Formula / weight: C₇₈H₁₂₃N₂₃O₂₃S₂ · 1815.1 g/mol (avg)
Also known as: L-PHENYLALANINE, L-TYROSYL-L-LEUCYL-L-ARGINYL-L-ISOLEUCYL-L-VALYL-L-GLUTAMINYL-L-CYSTEINYL-L-ARGINYL-L-SERYL-L-VALYL-L-.ALPHA.-GLUTAMYLGLYCYL-L-SERYL-L-CYSTEINYLGLYCYL-, CYCLIC (7->14)-DISULFIDE · TYR-LEU-ARG-ILE-VAL-GLN-CYS-ARG-SER-VAL-GLU-GLY-SER-CYS-GLY-PHE CYCLIC (7->14)-DISULFIDE
Code names: AOD9604

Resolves to

Compound

UNII7UP768IP4MCAS221231-10-3

Structure

InChIKeyGVIYUKXRXPXMQM-BPXGDYAESA-NSMILES

[H][C@](N)(CC1=CC=C(O)C=C1)C(\O)=N\[C@@]([H])(CC(C)C)C(\O)=N\[C@@]([H])(CCCNC(N)=N)C(\O)=N\[C@]([H])(C(\O)=N\[C@@]([H])(C(C)C)C(\O)=N\[C@@]([H])(CCC(O)=N)C(\O)=N\[C@@]1([H])CSSC[C@]([H])(\N=C(O)\[C@]([H])(CO)\N=C(O)/C\N=C(O)/[C@]([H])(CCC(O)=O)\N=C(O)\[C@@]([H])(\N=C(O)\[C@]([H])(CO)\N=C(O)/[C@]([H])(CCCNC(N)=N)\N=C1/O)C(C)C)C(\O)=N\C\C(O)=N\[C@@]([H])(CC1=CC=CC=C1)C(O)=O)[C@@]([H])(C)CC

Targets

P10912GHR

What you can answer from here — as of April 02, 2025

1Protein targetEach mapped to UniProt, with action and pharmacological action

Listed above

1+ReferenceStructured and connected to the statements they support

Which drugs share a target with AOD9604, and which of those have an active Phase 3 trial?

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