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AOD9604

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Identification

Generic Name
AOD9604
DrugBank Accession Number
DB06388
Background

AOD9604 is a synthetic analogue of the lipolytic domain of human growth hormone, being investigated for the treatment of obesity.

Type
Small Molecule
Groups
Investigational
Structure
Similar Structures
Weight
Average: 1815.1
Monoisotopic: 1813.860359661
Chemical Formula
C78H123N23O23S2
Synonyms
  • L-PHENYLALANINE, L-TYROSYL-L-LEUCYL-L-ARGINYL-L-ISOLEUCYL-L-VALYL-L-GLUTAMINYL-L-CYSTEINYL-L-ARGINYL-L-SERYL-L-VALYL-L-.ALPHA.-GLUTAMYLGLYCYL-L-SERYL-L-CYSTEINYLGLYCYL-, CYCLIC (7->14)-DISULFIDE
  • TYR-LEU-ARG-ILE-VAL-GLN-CYS-ARG-SER-VAL-GLU-GLY-SER-CYS-GLY-PHE CYCLIC (7->14)-DISULFIDE
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Pharmacology

Indication

Investigated for use/treatment in obesity and osteoporosis.

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Contraindications & Blackbox Warnings
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Pharmacodynamics

Not Available

Mechanism of action

AOD9604 is a 16-amino acid, orally active peptide modelled on one fragment of the human Growth Hormone molecule. Studies suggest that AOD9604 retains the bone stimulating properties of human Growth Hormone. AOD9604 indicates that this drug may have a role in the prevention and possible treatment of osteoporosis, through direct action on osteoblasts, the cells which build new bone.

Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available

Categories

Drug Categories
Classification
Not classified
Affected organisms
Not Available

Chemical Identifiers

UNII
7UP768IP4M
CAS number
221231-10-3
InChI Key
GVIYUKXRXPXMQM-BPXGDYAESA-N
InChI
InChI=1S/C78H123N23O23S2/c1-9-41(8)62(101-68(115)47(18-14-28-86-78(83)84)91-69(116)50(29-38(2)3)95-63(110)45(79)30-43-19-21-44(104)22-20-43)75(122)100-61(40(6)7)74(121)94-49(23-25-56(80)105)67(114)98-55-37-126-125-36-54(65(112)88-32-57(106)89-51(76(123)124)31-42-15-11-10-12-16-42)97-70(117)52(34-102)90-58(107)33-87-64(111)48(24-26-59(108)109)93-73(120)60(39(4)5)99-71(118)53(35-103)96-66(113)46(92-72(55)119)17-13-27-85-77(81)82/h10-12,15-16,19-22,38-41,45-55,60-62,102-104H,9,13-14,17-18,23-37,79H2,1-8H3,(H2,80,105)(H,87,111)(H,88,112)(H,89,106)(H,90,107)(H,91,116)(H,92,119)(H,93,120)(H,94,121)(H,95,110)(H,96,113)(H,97,117)(H,98,114)(H,99,118)(H,100,122)(H,101,115)(H,108,109)(H,123,124)(H4,81,82,85)(H4,83,84,86)/t41-,45-,46-,47-,48-,49-,50-,51-,52-,53-,54-,55-,60-,61-,62-/m0/s1
IUPAC Name
SMILES
[H][C@](N)(CC1=CC=C(O)C=C1)C(\O)=N\[C@@]([H])(CC(C)C)C(\O)=N\[C@@]([H])(CCCNC(N)=N)C(\O)=N\[C@]([H])(C(\O)=N\[C@@]([H])(C(C)C)C(\O)=N\[C@@]([H])(CCC(O)=N)C(\O)=N\[C@@]1([H])CSSC[C@]([H])(\N=C(O)\[C@]([H])(CO)\N=C(O)/C\N=C(O)/[C@]([H])(CCC(O)=O)\N=C(O)\[C@@]([H])(\N=C(O)\[C@]([H])(CO)\N=C(O)/[C@]([H])(CCCNC(N)=N)\N=C1/O)C(C)C)C(\O)=N\C\C(O)=N\[C@@]([H])(CC1=CC=CC=C1)C(O)=O)[C@@]([H])(C)CC

References

General References
Not Available
ChemSpider
57582224
Wikipedia
AOD9604

Clinical Trials

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Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Solid
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available
Chromatographic Properties
Collision Cross Sections (CCS)
Not Available

Drug created at March 19, 2008 16:28 / Updated at August 08, 2024 23:11