Intercellular Signaling Peptides and Proteins

Name
Intercellular Signaling Peptides and Proteins
Accession Number
DBCAT000080
Description

Regulatory proteins and peptides that are signaling molecules involved in the process of PARACRINE COMMUNICATION. They are generally considered factors that are expressed by one cell and are responded to by receptors on another nearby cell. They are distinguished from HORMONES in that their actions are local rather than distal.

Drugs
DrugDrug Description
PegfilgrastimA recombinant human granulocyte colony stimulating factor used to stimulate the production of neutrophils and prevent febrile neutropenia or infections after myelosuppressive chemotherapy.
AnakinraA recombinant form of human interleukin-1 receptor antagonist used in the treatment of rheumatoid arthritis and neonatal-onset multisystem inflammatory disease.
MecaserminA recombinant insulin-like growth factor-1 used for the long-term treatment of growth failure in pediatric patients with primary IGF-1 deficiency or with growth hormone gene deletion due to the development of neutralizing antibodies to GH.
MetreleptinA leptin analogue used as an adjunct to diet as replacement therapy to treat the complications of leptin deficiency in patients with congenital or acquired generalized lipodystrophy.
Peginterferon beta-1aAn interferon beta used to treat relapsing forms of multiple sclerosis.
Human interferon betaA polypeptide drug used in the treatment of relapsing forms of Multiple Sclerosis (MS).
Drugs & Drug Targets
DrugTargetType
PegfilgrastimGranulocyte colony-stimulating factor receptortarget
PegfilgrastimNeutrophil elastaseenzyme
AnakinraInterleukin-1 receptor type 1target
MecaserminInsulin-like growth factor 1 receptortarget
MecaserminInsulin-like growth factor-binding protein 3target
MecaserminInsulin receptortarget
MecaserminCation-independent mannose-6-phosphate receptortarget
MecaserminInsulin-like growth factor-binding protein 3carrier
MecaserminInsulin-like growth factor-binding protein complex acid labile subunitcarrier
MecaserminInsulin-like growth factor-binding protein 1carrier
MecaserminInsulin-like growth factor-binding protein 2carrier
MecaserminInsulin-like growth factor-binding protein 4carrier
MecaserminInsulin-like growth factor-binding protein 5carrier
MecaserminInsulin-like growth factor-binding protein 6carrier
MetreleptinLeptin receptortarget
Peginterferon beta-1aCytochrome P450 1A2enzyme
Peginterferon beta-1aInterferon alpha/beta receptor 1target
Human interferon betaCytochrome P450 1A2enzyme
Human interferon betaInterferon alpha/beta receptor 1target
Human interferon betaSerum albumincarrier