Identification

Generic Name
Basic Fibroblast Growth Factor
DrugBank Accession Number
DB14131
Background

Basic Fibroblast Growth Factor (bFGF) is a single-chain polypeptide growth factor that plays a significant role in the process of wound healing and is a potent inducer of physiologic angiogenesis. Several different forms of the human protein exist ranging from 18-24 kDa in size due to the use of alternative start sites within the fgf-2 gene. It has a 55 percent amino acid residue identity to Fibroblast Growth Factor 1 and has potent heparin-binding activity. The growth factor is an extremely potent inducer of DNA synthesis in a variety of cell types from mesoderm and neuroectoderm lineages. It was originally named basic fibroblast growth factor based upon its chemical properties and to distinguish it from acidic fibroblast growth factor (Fibroblast Growth Factor 1). Although it is not approved for use in Canada or the USA, bFGF is currently undergoing investigation in a number of clinical trials.

Type
Biotech
Groups
Investigational
Biologic Classification
Protein Based Therapies
Peptides
Protein Chemical Formula
Not Available
Protein Average Weight
Not Available
Sequences
Not Available
Synonyms
  • Basic astrolial growth factor
  • Basic FGF
  • Basic fibroblast growth factor, recombinant human, KCB-1
  • bFGF
  • FGF 2
  • Fibroblast growth factor, basic
  • Heparin-binding growth factor 2
  • KCB-1
  • Recombinant human basic fibroblast growth factor, KCB-1
External IDs
  • CCRIS 8682
  • FCE 26184

Pharmacology

Indication

Basic Fibroblast Growth Factor is not currently approved for any FDA or Health Canada approved indications.

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Contraindications & Blackbox Warnings
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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available

Products

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Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
Cosmeceutical Mask PackBasic Fibroblast Growth Factor (0.044 mg/22g) + Mecasermin (0.044 mg/22g) + Nepidermin (0.044 mg/22g) + Palmitoyl oligopeptide (0.044 mg/22g) + Prezatide copper (0.22 mg/22g) + Thioredoxin (0.044 mg/22g)PatchTopicalYBK Investment, INC2013-10-212013-10-29US flag
Cosmeceutical Mask PackBasic Fibroblast Growth Factor (0.044 mg/22g) + Mecasermin (0.044 mg/22g) + Nepidermin (0.044 mg/22g) + Palmitoyl oligopeptide (0.044 mg/22g) + Prezatide copper (0.22 mg/22g) + Thioredoxin (0.044 mg/22g)PatchTopicalYBK Investment, INC2013-10-21Not applicableUS flag
Dermaheal Cosmeceutical Mask Pack PlusBasic Fibroblast Growth Factor (0.044 mg/22g) + Mecasermin (0.044 mg/22g) + Nepidermin (0.044 mg/22g) + Palmitoyl oligopeptide (0.044 mg/22g) + Prezatide copper (0.22 mg/22g) + Thioredoxin (0.044 mg/22g)PatchTopicalYBK Investment, INC2013-10-21Not applicableUS flag
Oliglo Golden Radiance Complete FacialBasic Fibroblast Growth Factor (0.001 g/100mL) + Green tea leaf (1.2 g/100mL)Kit; LiquidTopicalDastmalchi LLC2019-10-30Not applicableUS flag
Pepplus Special Skin Care Lifting ProgramBasic Fibroblast Growth Factor (0.001 g/100mL) + Green tea leaf (1.28 g/100mL) + Prezatide copper (0.002 g/100mL)KitTopicalPicobio Co., Ltd.2021-11-02Not applicableUS flag
Special Skin Care Lifting ProgramBasic Fibroblast Growth Factor (0.001 g/100mL) + Green tea leaf (1.28 g/100mL) + Prezatide copper (0.002 g/100mL)KitTopicalPicobio Co., Ltd.2019-05-15Not applicableUS flag
Unapproved/Other Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
Cosmeceutical Mask PackBasic Fibroblast Growth Factor (0.044 mg/22g) + Mecasermin (0.044 mg/22g) + Nepidermin (0.044 mg/22g) + Palmitoyl oligopeptide (0.044 mg/22g) + Prezatide copper (0.22 mg/22g) + Thioredoxin (0.044 mg/22g)PatchTopicalYBK Investment, INC2013-10-212013-10-29US flag
Cosmeceutical Mask PackBasic Fibroblast Growth Factor (0.044 mg/22g) + Mecasermin (0.044 mg/22g) + Nepidermin (0.044 mg/22g) + Palmitoyl oligopeptide (0.044 mg/22g) + Prezatide copper (0.22 mg/22g) + Thioredoxin (0.044 mg/22g)PatchTopicalYBK Investment, INC2013-10-21Not applicableUS flag
Dermaheal Cosmeceutical Mask Pack PlusBasic Fibroblast Growth Factor (0.044 mg/22g) + Mecasermin (0.044 mg/22g) + Nepidermin (0.044 mg/22g) + Palmitoyl oligopeptide (0.044 mg/22g) + Prezatide copper (0.22 mg/22g) + Thioredoxin (0.044 mg/22g)PatchTopicalYBK Investment, INC2013-10-21Not applicableUS flag
Oliglo Golden Radiance Complete FacialBasic Fibroblast Growth Factor (0.001 g/100mL) + Green tea leaf (1.2 g/100mL)Kit; LiquidTopicalDastmalchi LLC2019-10-30Not applicableUS flag
Pepplus Special Skin Care Lifting ProgramBasic Fibroblast Growth Factor (0.001 g/100mL) + Green tea leaf (1.28 g/100mL) + Prezatide copper (0.002 g/100mL)KitTopicalPicobio Co., Ltd.2021-11-02Not applicableUS flag
Special Skin Care Lifting ProgramBasic Fibroblast Growth Factor (0.001 g/100mL) + Green tea leaf (1.28 g/100mL) + Prezatide copper (0.002 g/100mL)KitTopicalPicobio Co., Ltd.2019-05-15Not applicableUS flag

Categories

Drug Categories
Chemical TaxonomyProvided by Classyfire
Description
Not Available
Kingdom
Organic Compounds
Super Class
Organic Acids
Class
Carboxylic Acids and Derivatives
Sub Class
Amino Acids, Peptides, and Analogues
Direct Parent
Peptides
Alternative Parents
Not Available
Substituents
Not Available
Molecular Framework
Not Available
External Descriptors
Not Available
Affected organisms
Not Available

Chemical Identifiers

UNII
S3529G9M9V
CAS number
106096-93-9

References

General References
Not Available
Not Available

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
2Active Not RecruitingTreatmentIntermittent Claudication / Peripheral Arterial Disease (PAD)1
2CompletedTreatmentPeriodontitis1
2CompletedTreatmentTympanic Membrane Perforation1
2Not Yet RecruitingTreatmentStomatitis1
2RecruitingTreatmentTympanic Membrane Perforation1
1CompletedTreatmentNeovascular Age-Related Macular Degeneration (nAMD)1
1, 2Enrolling by InvitationTreatmentEndometrial Fibrosis / Infertility, Female, of Uterine Origin1
0CompletedPreventionPeriodontitis1
Not AvailableRecruitingTreatmentFibroblast Growth Factors / Promotion of wound healing1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
FormRouteStrength
PatchTopical
Kit; liquidTopical
KitTopical
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available

Drug created at June 26, 2018 16:02 / Updated at June 12, 2020 16:53