- Nootropic Agents
- Accession Number
Drugs used to specifically facilitate learning or memory, particularly to prevent the cognitive deficits associated with dementias. These drugs act by a variety of mechanisms. While no potent nootropic drugs have yet been accepted for general use, several are being actively investigated.
Drug Drug Description Choline A nutrient found in a wide variety of vitamins including pre-natal formulations. Tacrine An anticholinesterase drug used for the management of Alzheimer's disease symptoms. Galantamine A cholinesterase inhibitor used to manage mild to moderate dementia associated with Alzheimer's Disease. Nicergoline An ergot derivative use for the treatment of symptoms associated with cerebrovascular abnormalities. Donepezil An acetylcholinesterase inhibitor used to treat the behavioral and cognitive effects of Alzheimer's Disease and other types of dementia. Ergoloid mesylate A nootropic with an unknown mechanism of action indicated in individuals over sixty who manifest signs and symptoms of an idiopathic decline in mental capacity. Aniracetam A nootropic drug used to ameliorate memory and attention disturbances accompanying cerebrovascular diseases and degenerative brain disorders. Cutamesine Investigated for use/treatment in strokes and depression. Acetylcarnitine An acetylated form of the amino acid derivative L-carnitine that assists in mitochondrial fatty acid metabolism. It is under investigation as a treatment for numerous conditions, including neuropathy, depression, and dementia. Piracetam A nootropic cyclic GABA derivative used in myoclonus, sickle cell disease, alcohol dependence, and as a general cognitive enhancer. Omega-3-acid ethyl esters A mixture of fatty acids used as an adjunct to diet to reduce triglyceride (TG) levels in adult patients with severe hypertriglyceridemia. Etiracetam Etiracetam is under investigation in clinical trial NCT01137110 (Comparison of Short Duration Levetiracetam to Extended Course for Seizure Prophylaxis After Subarachnoid Hemorrhage (SAH)). Vinpocetine A synthetic derivative of a vinca alkaloid used to treat neurological symptoms of cerebrovascular disease. Nefiracetam Nefiracetam has been used in trials studying the treatment of Alzheimer's Disease. Oxiracetam Not Annotated Meclofenoxate Not Annotated Hopantenic acid Hopantenic acid (Pantogam) is a central nervous system depressant. Hopantenic acid has a unique spectrum of pharmacological effects (nootropic, anticonvulsant, mild activating) in the absence of addiction, hyperstimulation or withdrawal... Citicoline An endogenous intermediate in the formation of phosphatidylcholine from choline which is thought to have neuroprotective effects. GSK-239512 GSK-239512 is under investigation in clinical trial NCT00474513 (An Imaging Study to Investigate the Distribution of GSK239512 in the Brain.). Cerebrolysin A proteolytic protein indicated in the treatment of cerebrovascular disorders.
- Drugs & Drug Targets