Nootropic Agents

Name
Nootropic Agents
Accession Number
DBCAT000278
Description

Drugs used to specifically facilitate learning or memory, particularly to prevent the cognitive deficits associated with dementias. These drugs act by a variety of mechanisms. While no potent nootropic drugs have yet been accepted for general use, several are being actively investigated.

Drugs
DrugDrug Description
CholineA nutrient found in a wide variety of vitamins including pre-natal formulations.
TacrineAn anticholinesterase drug used for the management of Alzheimer's disease symptoms.
GalantamineA cholinesterase inhibitor used to manage mild to moderate dementia associated with Alzheimer's Disease.
NicergolineAn ergot derivative use for the treatment of symptoms associated with cerebrovascular abnormalities.
DonepezilAn acetylcholinesterase inhibitor used to treat the behavioral and cognitive effects of Alzheimer's Disease and other types of dementia.
Ergoloid mesylateA nootropic with an unknown mechanism of action indicated in individuals over sixty who manifest signs and symptoms of an idiopathic decline in mental capacity.
AniracetamA nootropic drug used to ameliorate memory and attention disturbances accompanying cerebrovascular diseases and degenerative brain disorders.
CutamesineInvestigated for use/treatment in strokes and depression.
AcetylcarnitineAn acetylated form of the amino acid derivative L-carnitine that assists in mitochondrial fatty acid metabolism. It is under investigation as a treatment for numerous conditions, including neuropathy, depression, and dementia.
PiracetamA nootropic cyclic GABA derivative used in myoclonus, sickle cell disease, alcohol dependence, and as a general cognitive enhancer.
Omega-3-acid ethyl estersA mixture of fatty acids used as an adjunct to diet to reduce triglyceride (TG) levels in adult patients with severe hypertriglyceridemia.
EtiracetamEtiracetam is under investigation in clinical trial NCT01137110 (Comparison of Short Duration Levetiracetam to Extended Course for Seizure Prophylaxis After Subarachnoid Hemorrhage (SAH)).
VinpocetineA synthetic derivative of a vinca alkaloid used to treat neurological symptoms of cerebrovascular disease.
NefiracetamNefiracetam has been used in trials studying the treatment of Alzheimer's Disease.
OxiracetamNot Annotated
MeclofenoxateNot Annotated
Hopantenic acidHopantenic acid (Pantogam) is a central nervous system depressant. Hopantenic acid has a unique spectrum of pharmacological effects (nootropic, anticonvulsant, mild activating) in the absence of addiction, hyperstimulation or withdrawal...
CiticolineAn endogenous intermediate in the formation of phosphatidylcholine from choline which is thought to have neuroprotective effects.
GSK-239512GSK-239512 is under investigation in clinical trial NCT00474513 (An Imaging Study to Investigate the Distribution of GSK239512 in the Brain.).
CerebrolysinA proteolytic protein indicated in the treatment of cerebrovascular disorders.
Drugs & Drug Targets
DrugTargetType
CholineCholine-phosphate cytidylyltransferase Btarget
CholineAcetylcholinesterasetarget
CholineCholine-phosphate cytidylyltransferase Atarget
CholinePhospholipase D2target
CholineCholinesterasetarget
CholinePhospholipase D1target
CholinePhosphoethanolamine/phosphocholine phosphatasetarget
CholineSolute carrier family 22 member 2transporter
CholineSolute carrier family 22 member 1transporter
CholineSolute carrier family 22 member 3transporter
CholineSolute carrier family 22 member 5transporter
CholineSolute carrier family 22 member 4transporter
CholineCholine/ethanolaminephosphotransferase 1enzyme
CholineCholine transporter-like protein 1transporter
CholineCholine transporter-like protein 4transporter
CholineCholine transporter-like protein 2transporter
CholineCholine transporter-like protein 3transporter
CholineCholine/ethanolamine kinaseenzyme
CholineCholine O-acetyltransferaseenzyme
CholineCholine kinase alphaenzyme
CholineCholine dehydrogenase, mitochondrialenzyme
CholineHigh affinity choline transporter 1transporter
CholineNeuronal acetylcholine receptor subunit alpha-7target
TacrineAcetylcholinesterasetarget
TacrineCytochrome P450 1A2enzyme
TacrineCholinesterasetarget
TacrineP-glycoprotein 1transporter
TacrineLiver carboxylesterase 1target
GalantamineAcetylcholinesterasetarget
GalantamineCytochrome P450 3A4enzyme
GalantamineCytochrome P450 2D6enzyme
GalantamineCholinesterasetarget
GalantamineP-glycoprotein 1transporter
GalantamineNeuronal acetylcholine receptor subunit alpha-7target
GalantamineMuscle nicotinic acetylcholine receptortarget
NicergolineAlpha-1A adrenergic receptortarget
NicergolineCytochrome P450 2D6enzyme
DonepezilAcetylcholinesterasetarget
Donepezil5-hydroxytryptamine receptor 2Atarget
DonepezilCytochrome P450 3A4enzyme
DonepezilCytochrome P450 2D6enzyme
DonepezilCytochrome P450 2C9enzyme
DonepezilCholinesterasetarget
DonepezilNitric oxide synthase, braintarget
DonepezilTumor necrosis factor-inducible gene 6 proteintarget
DonepezilInterleukin-1 betatarget
DonepezilNuclear factor NF-kappa-Btarget
DonepezilATP-binding cassette sub-family G member 2transporter
DonepezilNMDA receptortarget
Ergoloid mesylateDopamine receptortarget
Ergoloid mesylateAlpha adrenergic receptortarget
Ergoloid mesylateBeta adrenergic receptortarget
Ergoloid mesylateSerotonin Receptorstarget
Ergoloid mesylateCytochrome P450 3A4enzyme
Aniracetam5-hydroxytryptamine receptor 2Atarget
AniracetamDopamine D2 receptortarget
AniracetamGlutamate receptor 2target
AniracetamGlutamate receptor 3target
AcetylcarnitineSolute carrier family 22 member 5transporter
AcetylcarnitineSolute carrier family 22 member 21transporter
Omega-3-acid ethyl estersSterol O-acyltransferase 1enzyme
Omega-3-acid ethyl estersSterol regulatory element-binding protein 1target
VinpocetineCytochrome P450 3A4enzyme
CiticolineLicC proteintarget