Cycloparaffins
- Name
- Cycloparaffins
- Accession Number
- DBCAT000359
- Description
Alicyclic hydrocarbons in which three or more of the carbon atoms in each molecule are united in a ring structure and each of the ring carbon atoms is joined to two hydrogen atoms or alkyl groups. The simplest members are cyclopropane (C3H6), cyclobutane (C4H8), cyclohexane (C6H12), and derivatives of these such as methylcyclohexane (C6H11CH3). (From Sax, et al., Hawley's Condensed Chemical Dictionary, 11th ed)
- Drugs
Drug Drug Description Vitamin A A vitamin important for retinal function that is used clinically to correct vitamin A deficiency. Tramadol A centrally-acting opioid agonist and SNRI (serotonin/norepinephrine reuptake inhibitor) used for the management of moderate to severe pain in adults. Tranexamic acid An antifibrinolytic used to reduce or prevent hemorrhagic episodes, especially in the context of hyperfibrinolytic disorders. Acitretin An oral retinoid used in the treatment of severe psoriasis. Adenosine A medication used in myocardial perfusion scintigraphy and to treat supraventricular tachycardia. Dicyclomine An antimuscarinic agent used to treat IBS. Isotretinoin A retinoid used to treat severe recalcitrant acne. Gabapentin An anticonvulsant medication used in the management of peripheral neuropathic pains, postherpetic neuralgia, and partial-onset seizures. Cilastatin A renal dehydropeptidase inhibitor used to prevent degradation of imipenem. Both medications are used together to treat a variety of infections. Vildagliptin A once-daily dipeptidyl peptidase 4 (DPP-4) inhibitor used in the management of type 2 diabetes mellitus. Desvenlafaxine An antidepressant agent and SNRI used for the treatment of major depressive disorders in adults. Bromhexine A mucolytic drug used to decrease the viscosity of mucus in the airway, enhancing mucus clearance. Fumagillin Not Available Peridinin Not Available Adamantane A tricyclo bridged hydrocarbon. [PubChem] Arylacenamide Investigated for use/treatment in cancer/tumors (unspecified), immunosuppressive, and prostate cancer. Bisphenol Z Not Available Prephenic acid Not Available Crocin Crocin has been investigated for the treatment of Hyperglycemia, Metabolic Syndrome, Hypertriglyceridemia, and Hypercholesterolemia. MK-0557 MK0557 has been investigated for the treatment of Schizophrenia and Paranoid Schizophrenia. GDC-0152 GDC-0152 has been used in trials studying the treatment of Solid Cancers. Beloranib Beloranib has been used in trials studying the treatment of Obesity, Over-weight, Type 2 Diabetes, Craniopharyngioma, and Hypothalamic Injury, among others. Gacyclidine Gacyclidine has been used in trials studying the treatment of Tinnitus. Norbixin Norbixin is under investigation in clinical trial NCT03820245 (Effect of Short-term Annatto Carotenoids Supplementation on Oxidative Stress Status in Healthy Individuals). alpha-Carotene Not Annotated Lutein Xanthophylls are taken for nutritional supplementation, and also for treating dietary shortage or imbalance. Venlafaxine A selective serotonin and norepinephrine reuptake inhibitor (SNRI) used for the treatment of major depression, generalized or social anxiety disorder, and panic disorder. Nitisinone A hydroxyphenylpyruvate dioxygenase inhibitor used as an adjunct to dietary restrictions for the treatment of hereditary tyrosinemia type 1 (HT-1), which causes intolerance to tyrosine containing foods. Picrotoxin Used internally for relieving respiratory distress. Also for use as an antidote in poisoning by CNS depressants, especially barbiturates. Montelukast A leukotriene receptor antagonist used as part of an asthma therapy regimen, to prevent exercise induced bronchoconstriction, and to treat seasonal allergic rhinitis. Hexylcaine Used as a local anesthetic for surface application, infiltration or nerve block Rimantadine An RNA synthesis inhibitor used to prevent influenza A infection. Alitretinoin A vitamin A derivative used to treat Kaposi's sarcoma and used off label to treat chronic hand eczema and psoriasis. Efavirenz A non-nucleoside reverse transcriptase inhibitor used to treat HIV infection or prevent the spread of HIV. Nateglinide A meglitinide used to treat non insulin dependent diabetes mellitus. Tretinoin A vitamin A derivative used to treat acne vulgaris and certain types of promyelocytic leukemia, as well as various skin conditions in over-the-counter medications. Sibutramine A norepinephrine, serotonin and dopamine reuptake inhibitor indicated to assist with weight loss in obesity. Ciclopirox A broad-spectrum topical antifungal agent used to treat mild to moderate onychomycosis of fingernails and toenails in immunocompetent patients. Ketamine A rapid-acting general anesthetic and NMDA receptor antagonist used for induction of anesthesia diagnostic and surgical procedures typically in combination with a muscle relaxant. Paclitaxel A taxoid chemotherapeutic agent used as first-line and subsequent therapy for the treatment of advanced carcinoma of the ovary, and other various cancers including breast and lung cancer. Docetaxel A taxoid antineoplastic agent used in the treatment of various cancers, such as locally advanced or metastatic breast cancer, metastatic prostate cancer, gastric adenocarcinoma, and head and neck cancer. 1-Phenylcyclohexylamine Not Available Roflumilast A selective phosphodiesterase-4 inhibitor indicated to decrease the risk of exacerbations in patients with severe chronic obstructive pulmonary disease (COPD) and to treat skin conditions such as plaque psoriasis and atopic dermatitis. Gabaculine Not Available Cyclohexanone Cyclohexanone (also known as oxocyclohexane, pimelic ketone, ketohexamethylene, cyclohexyl ketone or ketocyclohexane) is a six-carbon cyclic molecule with a ketone functional group. It is a colorless, oily liquid with an... Adamantanone Not Available 3-(cyclohexylamino)propanesulfonic acid Not Available Oseltamivir acid Not Available 4-Oxoretinol Not Available Isochorismic Acid Not Available Arotinoid acid Arotinoid acid is a retinoic acid analog which acts as a selective RAR agonist. Anhydrovitamin A Not Available Violaxanthin Not Available Cyclohexanol Monohydroxy derivatives of cyclohexanes that contain the general formula R-C6H11O. They have a camphorlike odor and are used in making soaps, insecticides, germicides, dry cleaning, and plasticizers. [PubChem] Cilomilast Investigated for use/treatment in chronic obstructive pulmonary disease (COPD). Eucalyptol A common ingredient in mouthwash and cosmetics derived naturally from the eucalyptus plant that is frequently used to to improve symptoms of airway mucus hypersecretion. N-Ethylretinamide N-Ethylretinamide is the ethylamide of all-trans B-retinoic acid. Shikimate-3-Phosphate Not Available 3-Dehydroshikimate Not Available Cycloleucine Cycloleucine is non-metabolisable amino acid formed by cyclization of leucine. It is also a specific and reversible inhibitor of nucleic acid methylation and widely used in biochemical experiments. Maraviroc A CCR5 co-receptor antagonist used with other antiretroviral medications to treat CCR5-tropic HIV-1 infection. Voglibose An alpha-glucosidase inhibitor indicated in the management of postprandial blood glucose in patients with type II diabetes. Neramexane Investigated for use/treatment in alzheimer's disease, hearing loss, and pain (acute or chronic). Apadenoson Investigated for use/treatment in cardiovascular disorders and inflammatory disorders (unspecified). Fenretinide Investigated for use/treatment in macular degeneration. SQ-109 Investigated for use/treatment in bacterial infection, infectious and parasitic disease (unspecified), and tuberculosis. Atl146e Investigated for use/treatment in inflammatory disorders (unspecified). Paclitaxel docosahexaenoic acid Investigated for use/treatment in breast cancer, colorectal cancer, gastric cancer, kidney cancer, lung cancer, pancreatic cancer, prostate cancer, and skin cancer. IRX-5183 Investigated for use/treatment in adverse effects (chemotherapy) and blood (blood forming organ disorders, unspecified). LGD-1550 Investigated for use/treatment in cancer/tumors (unspecified). AI-850 Investigated for use/treatment in breast cancer and solid tumors. Paclitaxel trevatide Investigated for use/treatment in brain cancer. Tedisamil Investigated for use/treatment in arrhythmia, atrial fibrillation, and angina. Saxagliptin An DPP-4 inhibitor used for the management of type 2 diabetes mellitus. AR-9281 Investigated for use/treatment in hypertension. Astaxanthin Investigated for use/treatment in eye disorders/infections, cancer/tumors (unspecified), and asthma. Beta carotene A vitamin A precursor found in various nutritional supplements and health products. Cabazitaxel An antineoplastic agent used in combination with corticosteroids to treat metastatic castration-resistant prostate cancer in patients previously treated with a docetaxel-containing treatment regimen. 3-Fluoro-4-{[(2R)-2-hydroxy-2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-2-naphthalenyl)acetyl]amino}benzoic acid Not Available 1-(adamantan-1-yl)-2-(1H-imidazol-1-yl)ethanone Not Available Platensimycin Not Available TNP-470 O-(chloroacetylcarbamoyl)fumagillol (TNP-470) has been used in trials studying the treatment of HIV Infections, Sarcoma, Kaposi, and Pancreatic Neoplasms. Levomilnacipran A selective serotonin and norepinephrine reuptake inhibitor (SNRI) used to treat major depressive disorder (MDD) in adults. (4R)-limonene Limonene is common in cosmetic products. As the main odor constituent of citrus (plant family Rutaceae), D-limonene is used in food manufacturing and some medicines, e.g. as a flavoring to... Cyclopentamine Cyclopentamine is a sympathomimetic alkylamine, classified as a vasoconstrictor. Cyclopentamine was an over the counter treatment for nasal congestion in Europe and Australia. It has been widely discontinued due to... Tasimelteon A melatonin receptor agonist used to treat Non- 24-Hour Sleep-Wake Disorder. Paritaprevir A direct acting antiviral agent used in combination with other antiviral agents for the treatment of Hepatitis C Virus (HCV) infections. Zeaxanthin Zeaxanthin is a most common carotenoid alcohols found in nature that is involved in the xanthophyll cycle. As a coexistent isomer of lutein, zeaxanthin is synthesized in plants and some... Pentoxyverine A medication used to suppress a cough in the common cold, flu, bronchitis, and sinusitis. Lycopene An ingredient found in a variety of supplements and vitamins. Caramiphen Caramiphen is a cholinergic antagonist used in Parkinson's disease. Additionally, it is used, in combination with phenylpropanolamine, as a cough suppressant and nasal decongestant for the symptomatic treatment of seasonal... Tiletamine This drug is a dissociative anesthetic agent that falls under the drug category of NMDA receptor antagonists. Tiletamine is chemically similar to another dissociative anesthetic, ketamine. Tiletamine hydrochloride, the salt... Grazoprevir An antiviral and NS3/4A protease inhibitor used to treat hepatitis C infections. Candoxatrilat A dicarboxylic acid monoamide obtained by formal condensation between the amino group of cis-4-aminocyclohexanecarboxylic acid and the cyclopentanecarboxylic acid group of 1-[(2S)-2-carboxy-3-(2-methoxyethoxy)propyl]cyclopentanecarboxylic acid. A potent inhibitor of neutral endopeptidase (NEP,... Ortataxel Ortataxel has been used in trials studying the treatment of Lymphoma, Lung Cancer, Glioblastoma, and Kidney Cancer. Peficitinib Peficitinib has been used in trials studying the treatment and basic science of Psoriasis, Pharmacodynamics, Drug Interactions, Colitis, Ulcerative, and RHEUMATOID ARTHRITIS, among others. Navarixin Navarixin has been investigated for the treatment of Asthma. Pevonedistat Pevonedistat has been used in trials studying the treatment of Lymphoma, Solid Tumors, Multiple Myeloma, Hodgkin Lymphoma, and Metastatic Melanoma, among others. Danoprevir Danoprevir has been used in trials studying the treatment of Hepatitis C, Chronic. Tanzisertib Tanzisertib has been used in trials studying the treatment of Fibrosis, Discoid Lupus, Pulmonary Fibrosis, Interstitial Lung Disease, and Lung Diseases, Interstitial, among others. Artefenomel Artefenomel has been investigated for the treatment of Malaria. Esketamine A NMDA receptor antagonist used for treatment-resistant depression. Vaniprevir Vaniprevir has been used in trials studying the treatment and diagnostic of Hepatitis C, Chronic Hepatitis C, Hepatitis C, Chronic, Chronic Hepatitis C Infection, and Chronic Genotype 1 Hepatitis C... Lomibuvir Lomibuvir has been used in trials studying the treatment of Chronic Hepatitis C Virus and Chronic Hepatitis C Virus Infection. Tesetaxel Tesetaxel has been used in trials studying the treatment of Cancer, Melanoma, Prostate Cancer, Gastric Carcinoma, and Advanced Melanoma, among others. Voxilaprevir A nonstructural protein 3 and 4a protease inhibitor used to treat Hepatitis C infections. Atagabalin Atagabalin has been used in trials studying the treatment of Insomnia, Primary Insomnia, and Nonrestorative Sleep. Zuretinol acetate Zuretinol acetate has been used in trials studying the treatment of Impaired Dark Adaptation, RP (Retinitis Pigmentosa), Retinitis Pigmentosa (RP), and LCA (Leber Congenital Amaurosis). Diphencyprone Diphencyprone has been used in trials studying the treatment and basic science of Melanoma, Ultraviolet Rays, Immunosuppression, Neoplasm Metastasis, and Hypersensitivity, Delayed, among others. PF-03654746 PF-03654746 has been investigated for the treatment of Narcolepsy, Schizophrenia, Tourette's Syndrome, and Excessive Daytime Sleepiness. Squaric acid dibutyl ester Squaric acid dibutyl ester is under investigation in clinical trial NCT01971385 (Safety and Efficacy of Squaric Acid Dibutyl Ester for the Treatment of Herpes Labialis). Losmapimod Losmapimod has been investigated for the prevention of Chronic Obstructive Pulmonary Disease. Dasotraline Dasotraline is a serotonin, norepinephrine and dopamine reuptake inhibitor (SNDRI) that is under investigation for the treatment of Binge Eating Disorder, Adult Attention Hyperactivity Disorder, Attention Deficit Hyperactivity Disorder, and... Milataxel Milataxel has been used in trials studying the treatment of Mesothelioma. PF-03654764 PF-03654764 has been used in trials studying the basic science and treatment of Allergic Rhinitis. ABT-384 ABT-384 has been used in trials studying the treatment of Alzheimer's Disease. MK-5108 MK-5108 has been used in trials studying the treatment of Cancer, Neoplasms, Tumors. AZD-9056 AZD9056 has been used in trials studying the basic science and treatment of Rheumatoid Arthritis. BMS-188797 BMS-188797 has been used in trials studying the treatment of Unspecified Adult Solid Tumor, Protocol Specific. BMS-184476 BMS-184476 has been used in trials studying the treatment of Unspecified Adult Solid Tumor, Protocol Specific. Opaganib Opaganib, also known as ABC294640, is a selective sphingosine kinase-2 (SK2) (https://go.drugbank.com/polypeptides/Q9NRA0) inhibitor that is orally administered. This drug has potential anticancer, anti-inflammatory, and antiviral activities, with potential applications in... Larotaxel Larotaxel has been used in trials studying the treatment of Cancer, Metastases, Breast Cancer, Breast Neoplasms, and Pancreatic Neoplasms, among others. AQX-1125 AQX-1125 has been used in trials studying the treatment of COPD, Atopic Dermatitis, Interstitial Cystitis, and Bladder Pain Syndrome. Lobaplatin Lobaplatin has been used in trials studying the treatment of Breast Cancer, Hepatocellular Carcinoma, and Lobaplatin and Gemcitabine in Combination, Second-line Treatments on Advanced Osteosarcoma. Zidebactam Zidebactam is under investigation in clinical trial NCT02674347 (MAD Study to Evaluate the Safety, Tolerability and Pharmacokinetics of Intravenous Zidebactam in Healthy Adults). Fluciclovine (18F) A radiolabelled L-leucine derivative used to image tumors, especially in the prostate. Terpin hydrate An expectorant used to treat bronchitis, pneumonia, bronchiectasis, COPD, and infectious or inflammatory diseases of the upper respiratory tract. Guaiazulen Not Annotated Motretinide Not Annotated Bencyclane A vasodilator agent found to be effective in a variety of peripheral circulation disorders. It has various other potentially useful pharmacological effects. Its mechanism may involve block of calcium channels. Iprindole Not Annotated Rociverine An antispasmodic indicated in the treatment of urinary, gastrointestinal, and biliary tract spasms. Eberconazole Not Annotated Paclitaxel poliglumex Not Annotated Glecaprevir A Hepatitis C NS3/4A protease inhibitor used to treat Hepatitis C. Cyclopropane Cyclopropane was initially investigated because it was thought to be the toxic element in ethylene. Instead, it turned out to be an excellent anesthetic with very rapid onset and recovery... 13-cis-12-(3'-Carboxyphenyl)retinoic acid Not Annotated Menthol Not Annotated Narlaprevir Not Annotated ONO-2952 ONO-2952 is under investigation in clinical trial NCT01887002 (Study to Evaluate the Effects of ONO-2952 on Pain Perception Produced by Rectal Distention in Female Subjects With Diarrhea-Predominant Irritable Bowel Syndrome... Martinostat Martinostat is under investigation in clinical trial NCT03721211 (Imaging With [11C]Martinostat in Breast Cancer). Transfluthrin Transfluthrin is under investigation in clinical trial NCT02394522 (Spatial Repellent Products for Control of Vector Borne Diseases - Malaria - Zambia (SR-M-ZM)). Simotaxel Simotaxel is under investigation in clinical trial NCT00088647 (Study Evaluating MST-997 in Advanced Malignant Solid Tumors). Fucoxanthin Fucoxanthin is under investigation in clinical trial NCT03613740 (Effect of Fucoxanthin on the Components of the Metabolic Syndrome, Insulin Sensitivity and Insulin Secretion). Fucoxanthin isis a marine carotenoid mainly found... Cryptoxanthin Not Annotated Menthone A medication used to treat stone formation in the gallbladder and liver. Chamazulene Not Annotated SP-420 SP-420 is under investigation in clinical trial NCT03801889 (SP-420 in Subjects With Transfusion-dependent Beta-thalassemia or Other Rare Anemias). Axomadol Axomadol is under investigation in clinical trial NCT01043263 (Efficacy and Safety of EN3324 (Axomadol) in Subjects With Chronic Low Back Pain). Peretinoin Not Annotated Selodenoson Selodenoson is under investigation in clinical trial NCT00040001 (Safety and Efficacy Study of an A1-adenosine Receptor Agonist to Slow Heart Rate in Atrial Fibrillation). Itanapraced Not Annotated Abscisic Acid Not Annotated Dimethylaminomicheliolide Not Annotated TPI-287 Not Annotated Paclitaxel ceribate Not Available GSK-2879552 Not Annotated Abacavir An antiviral nucleoside reverse transcriptase inhibitor used in combination with other antiretrovirals for the treatment of HIV. Transcrocetinate Investigated for use/treatment in cancer/tumors (unspecified), hemorrhage, hypoxia, respiratory failure, and strokes. Avoralstat Avoralstat has been used in trials studying the prevention of HAE and Hereditary Angioedema. Abacavir hydroxyacetate Prurisol is under investigation for the treatment of Chronic Stable Plaque Psoriasis. Prurisol has been investigated for the treatment of Plaque Psoriasis. Janagliflozin Janagliflozin is under investigation in clinical trial NCT03851432 (Janagliflozin Treat Type 2 Diabetes Mellitus (T2DM) Inadequately Controlled With Metformin). Runcaciguat Not Annotated AB-001 Not Annotated ANG1005 Not Annotated GS-100 GS-100 is an adeno-associated virus serotype 9 virus particle containing viral DNA that includes an expression cassette containing the human NGLY1 gene coding sequence CC-90001 Not Annotated Nerandomilast Not Annotated Genipin Genipin is under investigation in clinical trial NCT05755750 (Intratendinous Genipin Injection in Horses With Tendon Injuries). Limonene, (+/-)- Limonene, (+/-)- is under investigation in clinical trial NCT05525260 (Limonene for Pulmonary Nodule Chemoprevention). Acoltremon Acoltremon is under investigation in clinical trial NCT05493111 (A Long-term Safety Study Evaluating the Safety and Systemic Exposure of AR-15512). Ruzinurad Ruzinurad is under investigation in clinical trial NCT04956432 (A Multicentre, Randomized, Double-blind, Allopurinol Controlled Study to Evaluate the Efficacy and Safety of SHR4640 in Subjects With Gout). - Drugs & Drug Targets