Acoltremon

DB19202ApprovedInvestigationalSmall moleculeTRPM8 Thermoreceptor Agonist

Acoltremon is under investigation in clinical trial NCT05493111 (A Long-term Safety Study Evaluating the Safety and Systemic Exposure of AR-15512).

Chemical structure of Acoltremon
Formula / weight
C18H27NO2 · 289.419 g/mol (avg)
First approval
United States, 2025
Also known as
Cyclohexanecarboxamide, n-(4-methoxyphenyl)-5-methyl-2-(1-methylethyl)-, (1r,2s,5r)- · N-(4-methoxyphenyl)-5-methyl-2- (1-methylethyl)cyclohexanecarboxamide, (1r,2s,5r)- · N-(4-methoxyphenyl)-p-menthanecarboxamide
Code names
AR-15512 · FEMA NO. 4681 · WS-12
Brand names
  • Tryptyr

Resolves to

Compound
UNII1L7BVT4Z4ZCAS68489-09-8ChEMBLCHEMBL2441929
Clinical / RWD
RxNorm2716801
Structure
InChIKeyHNSGVPAAXJJOPQ-XOKHGSTOSA-NSMILESCOC1=CC=C(NC(=O)[C@@H]2C[C@H](C)CC[C@H]2C(C)C)C=C1
Targets
Q7Z2W7TRPM8

What you can answer from here — as of December 10, 2025

1Protein targetEach mapped to UniProt, with action and pharmacological action
Listed above
11Clinical trialsPhase, status and sponsor resolved per trial
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1Marketed productAcross 1 country and 1 labeller
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1+ReferenceStructured and connected to the statements they support
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