Purinergic Antagonists

Name
Purinergic Antagonists
Accession Number
DBCAT000506
Description

Drugs that bind to and block the activation of PURINERGIC RECEPTORS.

Drugs
DrugDrug Description
CaffeineA stimulant present in tea, coffee, cola beverages, analgesic drugs, and agents used to increase alertness. It is also used in to prevent and treat pulmonary complications of premature birth.
TiclopidineA platelet aggregation inhibitor used in the prevention of conditions associated with thrombi, such as stroke and transient ischemic attacks (TIA).
TheophyllineA xanthine used to manage the symptoms of asthma, COPD, and other lung conditions caused by reversible airflow obstruction.
ClopidogrelAn antiplatelet agent used to prevent blood clots in peripheral vascular disease, coronary artery disease, and cerebrovascular disease.
EnprofyllineUsed in the management of symptoms of asthma. Also used in the treatment of peripheral vascular diseases and in the management of cerebrovascular insufficiency, sickle cell disease, and diabetic neuropathy.
AminophyllineA bronchodilator consisting of theophylline that is used for the treatment of bronchospasm due to asthma, emphysema and chronic bronchitis.
RegrelorInvestigated for use/treatment in cardiac surgery, coronary artery disease, thrombosis, and transfusion.
CangrelorA P2Y12 platelet receptor antagonist used during percutaneous coronary intervention to reduce the risk for periprocedural myocardial infarction (MI), repeat coronary revascularization, and stent thrombosis (ST).
NaxifyllineInvestigated for use/treatment in congestive heart failure.
VipadenantInvestigated for use/treatment in parkinson's disease.
TicagrelorA P2Y12 platelet inhibitor used in patients with a history of myocardial infarction or with acute coronary syndrome (ACS) to prevent future myocardial infarction, stroke and cardiovascular death.
IstradefyllineA selective adenoside A2A receptor antagonist indicated in adjunct to levodopa and carbidopa for the treatment of Parkinson's Disease.
8-cyclopentyl-1,3-dipropylxanthineCPX has been used in trials studying the treatment of Cystic Fibrosis.
Drugs & Drug Targets
DrugTargetType
CaffeineAdenosine receptor A1target
CaffeinecAMP-specific 3',5'-cyclic phosphodiesterase 4Btarget
CaffeineAdenosine receptor A2atarget
CaffeineCytochrome P450 1A2enzyme
CaffeineRyanodine receptor 1target
CaffeineCytochrome P450 3A4enzyme
CaffeineCytochrome P450 2E1enzyme
CaffeineCytochrome P450 2C8enzyme
CaffeineCytochrome P450 2C9enzyme
CaffeineCytochrome P450 1A1enzyme
CaffeineCytochrome P450 1B1enzyme
CaffeineCytochrome P450 2D6enzyme
CaffeineCyclic nucleotide phosphodiesterasetarget
CaffeineDNA-dependent protein kinase catalytic subunittarget
CaffeinePhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoformtarget
CaffeinePhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoformtarget
CaffeinePhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoformtarget
CaffeineInositol 1,4,5-trisphosphate receptortarget
CaffeineSerine-protein kinase ATMtarget
CaffeineATP-binding cassette sub-family G member 2transporter
CaffeineAdenosine receptor A2btarget
CaffeineAdenosine receptor A3target
CaffeinePhosphodiesterase enzymestarget
TiclopidineP2Y purinoceptor 12target
TiclopidineCytochrome P450 2C19enzyme
TiclopidineCytochrome P450 2B6enzyme
TiclopidineCytochrome P450 2C9enzyme
TiclopidineCytochrome P450 2D6enzyme
TiclopidineMyeloperoxidaseenzyme
TiclopidineCytochrome P450 1A2enzyme
TiclopidineCytochrome P450 2C8enzyme
TiclopidineCytochrome P450 2E1enzyme
TheophyllinecGMP-inhibited 3',5'-cyclic phosphodiesterase Atarget
TheophyllinecAMP-specific 3',5'-cyclic phosphodiesterase 4Btarget
TheophyllineAdenosine receptor A2btarget
TheophyllinecAMP-specific 3',5'-cyclic phosphodiesterase 4Atarget
TheophyllinecGMP-specific 3',5'-cyclic phosphodiesterasetarget
TheophyllineAdenosine receptor A1target
TheophyllineAdenosine receptor A2atarget
TheophyllineCytochrome P450 1A2enzyme
TheophyllineAdenosine deaminaseenzyme
TheophyllineCytochrome P450 2E1enzyme
TheophyllineCytochrome P450 3A4enzyme
TheophyllineSolute carrier family 22 member 7transporter
TheophyllineCytochrome P450 1A1enzyme
TheophyllineCytochrome P450 1B1enzyme
TheophyllineCytochrome P450 2D6enzyme
TheophyllineHistone deacetylase 2target
TheophyllineCopine-1target
TheophyllineMinor histocompatibility antigen H13target
TheophyllineNodal modulator 1target
TheophyllinePoly [ADP-ribose] polymerase 1target
TheophyllineProtein RIC-3target
TheophyllineTubulin monoglycylase TTLL3target
ClopidogrelP2Y purinoceptor 12target
ClopidogrelCytochrome P450 3A4enzyme
ClopidogrelCytochrome P450 2B6enzyme
ClopidogrelCytochrome P450 3A5enzyme
ClopidogrelCytochrome P450 2C19enzyme
ClopidogrelCytochrome P450 2C9enzyme
ClopidogrelCytochrome P450 1A2enzyme
ClopidogrelCytochrome P450 2C8enzyme
ClopidogrelLiver carboxylesterase 1enzyme
ClopidogrelP-glycoprotein 1transporter
ClopidogrelSolute carrier family 22 member 1transporter
ClopidogrelSolute carrier family 22 member 2transporter
EnprofyllinecAMP-specific 3',5'-cyclic phosphodiesterase 4Btarget
EnprofyllineAdenosine receptor A2btarget
EnprofyllinecAMP-specific 3',5'-cyclic phosphodiesterase 4Atarget
EnprofyllineAdenosine receptor A1target
EnprofyllineAdenosine receptor A2atarget
EnprofyllineAdenosine receptor A3target
AminophyllinecGMP-inhibited 3',5'-cyclic phosphodiesterase Atarget
AminophyllineAdenosine receptor A3target
AminophyllineAdenosine receptor A1target
AminophyllineCytochrome P450 1A2enzyme
AminophyllineCytochrome P450 2E1enzyme
AminophyllineCytochrome P450 3A4enzyme
AminophyllineHistone deacetylase 2target
RegrelorP2Y purinoceptor 12target
CangrelorP2Y purinoceptor 12target
NaxifyllineAdenosine receptor A1target
TicagrelorCytochrome P450 3A4enzyme
TicagrelorP2Y purinoceptor 12target
TicagrelorP-glycoprotein 1transporter
TicagrelorCytochrome P450 2C9enzyme
TicagrelorSerum albumincarrier
IstradefyllineCytochrome P450 1A1enzyme
IstradefyllineCytochrome P450 3A4enzyme
IstradefyllineCytochrome P450 3A5enzyme
IstradefyllineCytochrome P450 1A2enzyme
IstradefyllineCytochrome P450 2B6enzyme
IstradefyllineCytochrome P450 2C8enzyme
IstradefyllineCytochrome P450 2C9enzyme
IstradefyllineCytochrome P450 2C18enzyme
IstradefyllineCytochrome P450 2D6enzyme
IstradefyllineCytochrome P450 3A Subfamilyenzyme
IstradefyllineP-glycoprotein 1transporter
IstradefyllineAdenosine receptor A2atarget
IstradefyllineAdenosine receptor A1target
IstradefyllineSerum albumincarrier
Istradefyllinealpha1-acid glycoproteincarrier
IstradefyllineATP-binding cassette sub-family G member 2transporter
IstradefyllineSolute carrier organic anion transporter family member 1B1transporter
IstradefyllineSolute carrier organic anion transporter family member 1B3transporter
IstradefyllineSolute carrier family 22 member 6transporter
IstradefyllinePOU domain, class 2, transcription factor 2transporter
IstradefyllineMultidrug and toxin extrusion protein 1transporter
IstradefyllineMultidrug and toxin extrusion protein 2transporter