- Topoisomerase Inhibitors
- Accession Number
Compounds that inhibit the activity of DNA TOPOISOMERASES.
Drug Drug Description Teniposide A cytotoxic drug used as an adjunct for chemotherapy induction in the treatment of refractory childhood acute lymphoblastic leukemia. Irinotecan An antineoplastic enzyme inhibitor used to treat metastatic carcinoma of the colon or rectum. Etoposide A podophyllotoxin derivative used to treat testicular and small cell lung tumors. Topotecan An antineoplastic agent used to treat ovarian cancer, small cell lung cancer, or cervical cancer. Mitoxantrone A chemotherapeutic agent used for the treatment of secondary progressive, progressive relapsing, or worsening relapsing-remitting multiple sclerosis. Moxifloxacin A fluoroquinolone antibiotic used to treat various bacterial infections. Grepafloxacin A fluoroquinolone antibiotic used to treat various gram positive and gram negative bacterial infections. Dexrazoxane A cytoprotective drug used to prevent and improve cardiomyopathy associated with doxorubicin treatment for metastatic breast cancer. Valrubicin An anthracycline used intravesically in the treatment of BCG-resistant bladder carcinoma. Epirubicin An anthracycline topoisomerase II inhibitor used as an adjuvant to treating axillary node metastases in patients who have undergone surgical resection of primary breast cancer. Enoxacin For the treatment of adults (≥18 years of age) with the following infections caused by susceptible strains of the designated microorganisms: (1) uncomplicated urethral or cervical gonorrhea due to Neisseria... Pefloxacin An antibiotic used to treat a variety of bacterial infections. Ciprofloxacin A second generation fluoroquinolone used to treat various susceptible bacterial infections. Trovafloxacin An antibiotic used to treat gonorrhea and chlamydia. Daunorubicin An anthracycline aminoglycoside used to induce remission of nonlymphocytic leukemia and acute lymphocytic leukemia. Nalidixic acid A quinolone antibiotic used to treat urinary tract infections. Cinoxacin For the treatment of initial and recurrent urinary tract infections in adults caused by the following susceptible microorganisms: Escherichia coli, Proteus mirabilis, Proteus vulgaris, Klebsiella species (including K. pneumoniae), and... Lomefloxacin A fluoroquinolone used to prevent and treat a wide variety of infections in the body. Doxorubicin A medication used to treat various cancers and Kaposi's Sarcoma. Gatifloxacin A fourth generation fluoroquinolone used to treat a wide variety of infections in the body. Norfloxacin A broad-spectrum fluoroquinolone antibiotic with variable activity against gram-positive and gram-negative bacteria. Typically reserved for the treatment of UTIs due to accumulation in the urine. Levofloxacin A fluoroquinolone antibiotic used to treat infections caused by susceptible bacteria of the upper respiratory tract, skin and skin structures, urinary tract, and prostate, as well as for post-exposure treatment of inhaled anthrax and the plague. Gemifloxacin A quinolone antibacterial agent used for the treatment of acute bacterial exacerbation of chronic bronchitis and mild to moderate community-acquired pneumonia caused by susceptible bacteria. Ofloxacin An antibacterial agent used for the treatment of bacterial infections in many parts of the body, including the respiratory tract, kidney, skin, soft tissue, and urinary tract. Idarubicin An anthracycline antineoplastic agent used to treat acute myeloid leukemia (AML) in adults. Sparfloxacin A fluoroquinolone antibiotic used to treat bacterial respiratory infections and sinusitis. Temafloxacin For the treatment of lower respiratory tract infections, genital and urinary infections like prostatitis, and skin infections. Fleroxacin Fleroxacin is a broad-spectrum antimicrobial fluoroquinolone. Camptothecin Investigated for the treatment of cancer. Rubitecan Investigated for use/treatment in pancreatic cancer, leukemia (unspecified), melanoma, ovarian cancer, and cancer/tumors (unspecified). Garenoxacin Investigated for use/treatment in bacterial infection. Pixantrone An antineoplastic agent use to treat patients with relapsed or refractory aggressive Non-Hodgkin B-cell Lymphomas (NHL). MLN576 Investigated for use/treatment in solid tumors. Besifloxacin A fluoroquinolone antibiotic agent used for the treatment of bacterial conjunctivitis. Flumequine Flumequine is a synthetic chemotherapeutic antibiotic of the fluoroquinolone drug class used to treat bacterial infections. Alatrofloxacin A fluoroquinolone antibiotic used to treat a variety of bacterial infections. Aclarubicin Not Annotated Pazufloxacin Pazufloxacin is under investigation in clinical trial NCT02592096 (Pazufloxacin Mesilate Ear Drops Clinical Trial Protocol). Acridine Carboxamide Acridine Carboxamide has been used in trials studying the treatment of Lung Cancer and Brain and Central Nervous System Tumors. Prulifloxacin A broad-spectrum fluoroquinolone antibiotic used to treat a variety of susceptible bacterial infections. Exatecan Exatecan has been used in trials studying the treatment of Sarcoma, Leukemia, Lymphoma, Lung Cancer, and Liver Cancer, among others. Nadifloxacin A topical fluoroquinolone used in the treatment of acne and topical bacterial skin infections. Belotecan Belotecan has been investigated for the treatment of Epithelial Ovarian Cancer. TU-100 TU-100 has been used in trials studying the treatment of Abdominal Pain, Colonic Transit, Crohn's Disease, Rectal Sensation, and Gastric Emptying, among others. Daidzein Not Annotated Sitafloxacin A fluoroquinolone antibiotic indicated in the treatment of susceptible bacterial infections. Oxolinic acid Not Annotated Rufloxacin A fluoroquinolone antibiotic indicated in the treatment of susceptible respiratory infections and uncomplicated cystitis. Coumermycin A1 Not Annotated Clinafloxacin Clinafloxacin is a fluoroquinolone antibacterial currently under research. It has been proven to present good antibiotic properties. However, its approval and release have been halted due to the presence of... 7-ethyl-10-hydroxycamptothecin Investigated for use/treatment in colorectal cancer. Finafloxacin Finafloxacin is indicated for the treatment of acute otitis externa (AOE) with or without an otowick, caused by susceptible strains of Pseudomonas aeruginosa and Staphylococcus aureus in patients age 1... Etirinotecan pegol Etirinotecan pegol is under investigation in clinical trial NCT01663012 (Phase II NKTR-102 In Bevacizumab-Resistant High Grade Glioma). Sacituzumab govitecan Sacituzumab govitecan targets TROP-2-expressing cancer cells through a humanized antibody (RS7) before subsequently becoming internalized and releasing the topoisomerase I inhibitor SN-38 to induce DNA damage-mediated apoptosis. Trastuzumab deruxtecan An antibody used to treat certain types of unresectable or metastatic HER-2 positive breast cancer. Etoposide toniribate Not Annotated
- Drugs & Drug Targets