Topoisomerase Inhibitors
- Name
- Topoisomerase Inhibitors
- Accession Number
- DBCAT000548
- Description
Compounds that inhibit the activity of DNA TOPOISOMERASES.
- Drugs
Drug Drug Description Aclarubicin Not Annotated Acridine Carboxamide Acridine Carboxamide has been used in trials studying the treatment of Lung Cancer and Brain and Central Nervous System Tumors. Alatrofloxacin A fluoroquinolone antibiotic used to treat a variety of bacterial infections. Amifloxacin Amifloxacin is a small molecule drug. The usage of the INN stem '-oxacin' in the name indicates that Amifloxacin is a nalidixic acid derivative antibacterial. Amifloxacin has a monoisotopic molecular... Belotecan Belotecan has been investigated for the treatment of Epithelial Ovarian Cancer. Besifloxacin A fluoroquinolone antibiotic agent used for the treatment of bacterial conjunctivitis. Camptothecin Investigated for the treatment of cancer. Cinoxacin For the treatment of initial and recurrent urinary tract infections in adults caused by the following susceptible microorganisms: Escherichia coli, Proteus mirabilis, Proteus vulgaris, Klebsiella species (including K. pneumoniae), and... Ciprofloxacin A second generation fluoroquinolone used to treat various susceptible bacterial infections. Clinafloxacin Clinafloxacin is a fluoroquinolone antibacterial currently under research. It has been proven to present good antibiotic properties. However, its approval and release have been halted due to the presence of... Coumermycin A1 Not Annotated Daidzein Not Annotated Daunorubicin An anthracycline aminoglycoside used to induce remission of nonlymphocytic leukemia and acute lymphocytic leukemia. Dexrazoxane A cytoprotective drug used to prevent and improve cardiomyopathy associated with doxorubicin treatment for metastatic breast cancer. Doxorubicin A medication used to treat various cancers, including AIDS-associated Kaposi's Sarcoma and metastatic cancers. Enoxacin For the treatment of adults (≥18 years of age) with the following infections caused by susceptible strains of the designated microorganisms: (1) uncomplicated urethral or cervical gonorrhea due to Neisseria... Epirubicin An anthracycline topoisomerase II inhibitor used as an adjuvant to treating axillary node metastases in patients who have undergone surgical resection of primary breast cancer. Etirinotecan pegol Etirinotecan pegol is under investigation in clinical trial NCT01663012 (Phase II NKTR-102 In Bevacizumab-Resistant High Grade Glioma). Etoposide A podophyllotoxin derivative used to treat testicular and small cell lung tumors. Etoposide toniribate Not Annotated Exatecan Exatecan has been used in trials studying the treatment of Sarcoma, Leukemia, Lymphoma, Lung Cancer, and Liver Cancer, among others. Finafloxacin Finafloxacin is indicated for the treatment of acute otitis externa (AOE) with or without an otowick, caused by susceptible strains of Pseudomonas aeruginosa and Staphylococcus aureus in patients age 1... Fleroxacin Fleroxacin is a broad-spectrum antimicrobial fluoroquinolone. Flumequine Flumequine is a synthetic chemotherapeutic antibiotic of the fluoroquinolone drug class used to treat bacterial infections. Garenoxacin Investigated for use/treatment in bacterial infection. Gatifloxacin A fourth generation fluoroquinolone used to treat a wide variety of infections in the body. Gemifloxacin A quinolone antibacterial agent used for the treatment of acute bacterial exacerbation of chronic bronchitis and mild to moderate community-acquired pneumonia caused by susceptible bacteria. Gepotidacin A triazaacenaphthylene bacterial type II topoisomerase inhibitor for the treatment of female patients with uncomplicated urinary tract infections caused by susceptible microorganisms. Grepafloxacin A fluoroquinolone antibiotic used to treat various gram positive and gram negative bacterial infections. Idarubicin An anthracycline antineoplastic agent used to treat acute myeloid leukemia (AML) in adults. Irinotecan A topoisomerase inhibitor used to treat metastatic carcinoma of the colon or rectum and pancreatic adenocarcinoma. Levofloxacin A fluoroquinolone antibiotic used to treat infections caused by susceptible bacteria of the upper respiratory tract, skin and skin structures, urinary tract, and prostate, as well as for post-exposure treatment of inhaled anthrax and the plague. Lomefloxacin A fluoroquinolone used to prevent and treat a wide variety of infections in the body. Mitoxantrone A chemotherapeutic agent used for the treatment of secondary progressive, progressive relapsing, or worsening relapsing-remitting multiple sclerosis. MLN576 Investigated for use/treatment in solid tumors. Moxifloxacin A fluoroquinolone antibiotic used to treat various bacterial infections. Nadifloxacin A topical fluoroquinolone used in the treatment of acne and topical bacterial skin infections. Nalidixic acid A quinolone antibiotic used to treat urinary tract infections. Norfloxacin A broad-spectrum fluoroquinolone antibiotic with variable activity against gram-positive and gram-negative bacteria. Typically reserved for the treatment of UTIs due to accumulation in the urine. Ofloxacin An antibacterial agent used for the treatment of bacterial infections in many parts of the body, including the respiratory tract, kidney, skin, soft tissue, and urinary tract. Oxolinic acid Not Annotated Ozenoxacin A quinolone antibiotic used to treat impetigo caused by susceptible bacteria. Pazufloxacin Pazufloxacin is under investigation in clinical trial NCT02592096 (Pazufloxacin Mesilate Ear Drops Clinical Trial Protocol). Pefloxacin An antibiotic used to treat a variety of bacterial infections. Pixantrone An antineoplastic agent use to treat patients with relapsed or refractory aggressive Non-Hodgkin B-cell Lymphomas (NHL). Prulifloxacin A broad-spectrum fluoroquinolone antibiotic used to treat a variety of susceptible bacterial infections. Rubitecan Investigated for use/treatment in pancreatic cancer, leukemia (unspecified), melanoma, ovarian cancer, and cancer/tumors (unspecified). Rufloxacin A fluoroquinolone antibiotic indicated in the treatment of susceptible respiratory infections and uncomplicated cystitis. Sacituzumab govitecan Sacituzumab govitecan targets TROP-2-expressing cancer cells through a humanized antibody (RS7) before subsequently becoming internalized and releasing the topoisomerase I inhibitor SN-38 to induce DNA damage-mediated apoptosis. Sitafloxacin A fluoroquinolone antibiotic indicated in the treatment of susceptible bacterial infections. SN-38 Investigated for use/treatment in colorectal cancer. Sobuzoxane Sobuzoxane is a small molecule drug. The usage of the INN stem '-oxan(e)' in the name indicates that Sobuzoxane is a benzodioxane derivative. Sobuzoxane has a monoisotopic molecular weight of... Sparfloxacin A fluoroquinolone antibiotic used to treat bacterial respiratory infections and sinusitis. Temafloxacin For the treatment of lower respiratory tract infections, genital and urinary infections like prostatitis, and skin infections. Teniposide A cytotoxic drug used as an adjunct for chemotherapy induction in the treatment of refractory childhood acute lymphoblastic leukemia. Topotecan An antineoplastic agent used to treat ovarian cancer, small cell lung cancer, or cervical cancer. Trastuzumab deruxtecan An antibody used to treat certain types of unresectable or metastatic HER2 positive breast cancer. Trovafloxacin An antibiotic used to treat gonorrhea and chlamydia. TU-100 TU-100 has been used in trials studying the treatment of Abdominal Pain, Colonic Transit, Crohn's Disease, Rectal Sensation, and Gastric Emptying, among others. Valrubicin An anthracycline used intravesically in the treatment of BCG-resistant bladder carcinoma. Zoliflodacin A spiropyrimidinetrione bacterial type II topoisomerase inhibitor indicated for the treatment of uncomplicated urogenital gonorrhea caused by Neisseria gonorrhoeae. - Drugs & Drug Targets