Camptothecin

DB04690InvestigationalSmall molecule

Camptothecin is an alkaloid isolated from the stem wood of the Chinese tree, Camptotheca acuminata. This compound selectively inhibits the nuclear enzyme DNA topoisomerase, type I. Several semisynthetic analogs of...

Mechanism: Camptothecin binds to the topoisomerase I and DNA complex resulting in a ternary complex, stabilizing it and preventing DNA re-ligation and therefore causes DNA damage which results in apoptosis.
Curator reviewed
Primary indication: Investigated for the treatment of cancer.Curator reviewed
Formula / weight: C₂₀H₁₆N₂O₄ · 348.352 g/mol (avg)
Also known as: D-camptothecin

Resolves to

Compound

UNIIXT3Z54Z28ACAS7689-03-4ChEMBLCHEMBL65ChEBI27656PubChem24360KEGGC01897

Clinical / RWD

PharmGKBPA153590860

Structure

InChIKeyVSJKWCGYPAHWDS-FQEVSTJZSA-NSMILESCC[C@@]1(O)C(=O)OCC2=C1C=C1N(CC3=CC4=CC=CC=C4N=C13)C2=O

Targets

P11387TOP1

Transporters

P08183ABCB1Q9UNQ0ABCG2

What you can answer from here — as of September 23, 2026

1Protein targetEach mapped to UniProt, with action and pharmacological action

Listed above

2TransportersSubstrate / inhibitor direction, not just membership

Listed above

165Drug interactionsStructured to mechanism, not free text

75Clinical trialsPhase, status and sponsor resolved per trial

11+ReferencesStructured and connected to the statements they support

Which drugs share a target with Camptothecin, and which of those have an active Phase 3 trial?

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