Benzothiadiazines

Name
Benzothiadiazines
Accession Number
DBCAT000575
Description

Heterocyclic compounds of a ring with SULFUR and two NITROGEN atoms fused to a BENZENE ring. Members inhibit SODIUM-POTASSIUM-CHLORIDE SYMPORTERS and are used as DIURETICS.

Drugs
DrugDrug Description
BendroflumethiazideA diuretic used to suppress lactation and to treat hypertension and edema.
ButhiazideA diuretic indicated in the treatment of edema caused by congestive heart failure, as well as hepatic and renal diseases.
ChlorothiazideA thiazide diuretic used to treat hypertension and edema in congestive heart failure, hepatic cirrhosis, and corticosteroid and estrogen therapy.
CyclopenthiazideCyclopenthiazide is a thiazide diuretic with antihypertensive properties. In a double blind, randomized crossover study, cyclopenthiazide was effective in reducing diastolic blood pressure in mildly hypertensive non-insulin dependent diabetic patients...
DiazoxideA non diuretic benzothiadiazine indicated for the management of hypoglycemia in patients who produce an excess of insulin caused by a variety of conditions.
HydrochlorothiazideA thiazide diuretic used to treat edema associated with a number of conditions, and hypertension.
HydroflumethiazideA thiazide diuretic used to treat hypertension as well as edema due to congestive heart failure and liver cirrhosis.
MethyclothiazideA diuretic drug used to treat hypertension and edema caused by heart failure, renal conditions, treatment with corticosteroids, and estrogen therapy.
PolythiazideA thiazide diuretic used in the management of hypertension and treatment of edema.
TrichlormethiazideUsed in the treatment of oedema (including that associated with heart failure) and hypertension.
Drugs & Drug Targets
DrugTargetType
BendroflumethiazideSolute carrier family 12 member 3target
BendroflumethiazideCarbonic anhydrase 1target
BendroflumethiazideCarbonic anhydrase 2target
BendroflumethiazideCarbonic anhydrase 4target
BendroflumethiazideCalcium-activated potassium channel subunit alpha-1target
BendroflumethiazideThiopurine S-methyltransferaseenzyme
BendroflumethiazideSolute carrier family 12 member 1target
ChlorothiazideSolute carrier family 22 member 6transporter
ChlorothiazideCarbonic anhydrase 2target
ChlorothiazideCarbonic anhydrase 1target
ChlorothiazideSolute carrier family 12 member 3target
CyclopenthiazideAlbumincarrier
DiazoxideCytochrome P450 3A4enzyme
DiazoxideATP-sensitive inward rectifier potassium channel 8target
DiazoxideBroad substrate specificity ATP-binding cassette transporter ABCG2transporter
DiazoxideOrganic anion transporter 3transporter
DiazoxideCytochrome P450 1A2enzyme
DiazoxideMitochondrial ATP synthase F1 domaintarget
DiazoxideAlbumincarrier
DiazoxideATP-sensitive inward rectifier potassium channel 11target
DiazoxideSolute carrier family 22 member 6transporter
HydrochlorothiazideSolute carrier family 12 member 3target
HydrochlorothiazideSolute carrier family 22 member 6transporter
HydrochlorothiazideCalcium-activated potassium channel subunit alpha-1target
HydrochlorothiazideAlbumincarrier
HydrochlorothiazideSolute carrier family 22 member 11transporter
HydrochlorothiazideATP-binding cassette sub-family C member 4transporter
HydrochlorothiazideOrganic anion transporter 3transporter
HydrochlorothiazideAngiotensin-converting enzymetarget
HydroflumethiazideOrganic anion transporter 3transporter
HydroflumethiazideCarbonic anhydrase 7target
HydroflumethiazideSolute carrier family 12 member 3target
HydroflumethiazideAlbumincarrier
HydroflumethiazideCarbonic anhydrase 12target
HydroflumethiazideCarbonic anhydrase 9target
HydroflumethiazideCarbonic anhydrase 1target
HydroflumethiazideCarbonic anhydrase 2target
HydroflumethiazideCalcium-activated potassium channel subunit alpha-1target
HydroflumethiazideCarbonic anhydrase 4target
HydroflumethiazideSodium/potassium-transporting ATPase subunit alpha-1target
HydroflumethiazideSolute carrier family 12 member 1target
HydroflumethiazideSolute carrier family 22 member 6transporter
MethyclothiazideSolute carrier family 12 member 1target
MethyclothiazideSolute carrier family 12 member 3target
MethyclothiazideCarbonic anhydrase 1target
MethyclothiazideCarbonic anhydrase 2target
MethyclothiazideCarbonic anhydrase 4target
PolythiazideSolute carrier family 12 member 3target
PolythiazideSolute carrier family 22 member 6transporter
PolythiazideOrganic anion transporter 3transporter
PolythiazideAlbumincarrier
TrichlormethiazideSolute carrier family 12 member 3target
TrichlormethiazideSodium/potassium-transporting ATPase subunit alpha-1target
TrichlormethiazideCarbonic anhydrase 4target
TrichlormethiazideCarbonic anhydrase 2target
TrichlormethiazideCarbonic anhydrase 1target
TrichlormethiazideThiopurine S-methyltransferaseenzyme
TrichlormethiazideSolute carrier family 12 member 1target