Dibenzocycloheptenes

Name
Dibenzocycloheptenes
Accession Number
DBCAT000742
Description

A family of tricyclic hydrocarbons whose members include many of the commonly used tricyclic antidepressants (ANTIDEPRESSIVE AGENTS, TRICYCLIC).

Drugs
DrugDrug Description
ProtriptylineA tricyclic antidepressant that is indicated in the treatment of depression only under close clinical supervision.
CyproheptadineA combined serotonin and histamine antagonist used in the treatment of allergic symptoms, for appetite stimulation, and off-label in the treatment of serotonin syndrome.
LoratadineA second generation antihistamine used to manage the symptoms of allergic rhinitis.
NortriptylineA tricyclic antidepressant used in the treatment of depression.
AzatadineAn H1 receptor antagonist used to treat perennial and allergic rhinitis as well as eustachian tube congestion.
CyclobenzaprineA skeletal muscle relaxant that works on the brainstem to treat muscle spasms of local origin.
DesloratadineA second generation tricyclic antihistamine used to treat seasonal and non seasonal allergic rhinitis, pruritus, and urticaria.
OMS-103HPInvestigated for use/treatment in inflammatory disorders (unspecified), knee replacement, orthopedic surgery, and pain (acute or chronic).
AmitriptylinoxideA tricyclic antidepressant indicated in the treatment of depressive disorders.
RupatadineA selective histamine H1 receptor antagonist and platelet activating factor (PAF) antagonist used to treat allergic rhinitis.
Drugs & Drug Targets
DrugTargetType
ProtriptylineSodium-dependent noradrenaline transportertarget
ProtriptylineSodium-dependent serotonin transportertarget
ProtriptylineP-glycoprotein 1transporter
Cyproheptadine5-hydroxytryptamine receptor 2Atarget
CyproheptadineHistamine H1 receptortarget
CyproheptadineMuscarinic acetylcholine receptor M1target
CyproheptadineMuscarinic acetylcholine receptor M2target
CyproheptadineMuscarinic acetylcholine receptor M3target
Cyproheptadine5-hydroxytryptamine receptor 2Ctarget
CyproheptadineUDP-glucuronosyltransferase 1-3enzyme
Cyproheptadine5-hydroxytryptamine receptor 7target
CyproheptadineUDP-glucuronosyltransferase 2B10enzyme
CyproheptadineUDP-glucuronosyltransferase 1-4enzyme
Cyproheptadine5-hydroxytryptamine receptor 2Btarget
CyproheptadineHistamine H2 receptortarget
CyproheptadineSolute carrier family 22 member 1transporter
CyproheptadineSerum albumincarrier
LoratadineHistamine H1 receptortarget
LoratadineCytochrome P450 3A4enzyme
LoratadineCytochrome P450 2C19enzyme
LoratadineCytochrome P450 2D6enzyme
LoratadineCytochrome P450 2C8enzyme
LoratadineP-glycoprotein 1transporter
LoratadinePotassium voltage-gated channel subfamily H member 2target
LoratadineBile salt export pumptransporter
LoratadineCytochrome P450 1A1enzyme
LoratadineCytochrome P450 1A2enzyme
LoratadineCytochrome P450 2B6enzyme
LoratadineCytochrome P450 2C9enzyme
LoratadineCytochrome P450 3A5enzyme
LoratadineUDP-glucuronosyltransferase 2B10enzyme
LoratadineUDP-glucuronosyltransferase 1-1enzyme
LoratadineUDP-glucuronosyltransferase 1-3enzyme
LoratadineUDP-glucuronosyltransferase 2B15enzyme
NortriptylineSodium-dependent serotonin transportertarget
NortriptylineSodium-dependent noradrenaline transportertarget
NortriptylineCytochrome P450 1A2enzyme
NortriptylineCytochrome P450 2D6enzyme
NortriptylineSerum albumincarrier
NortriptylineAlpha-1-acid glycoprotein 1carrier
NortriptylineHistamine H1 receptortarget
Nortriptyline5-hydroxytryptamine receptor 2Atarget
NortriptylineAlpha-1A adrenergic receptortarget
Nortriptyline5-hydroxytryptamine receptor 1Atarget
NortriptylineCytochrome P450 3A4enzyme
NortriptylineCytochrome P450 3A5enzyme
NortriptylineAlpha-1D adrenergic receptortarget
NortriptylineCytochrome P450 2C19enzyme
NortriptylineCytochrome P450 2E1enzyme
Nortriptyline5-hydroxytryptamine receptor 2Ctarget
NortriptylineAlpha-1B adrenergic receptortarget
NortriptylineAlpha-2 adrenergic receptorstarget
NortriptylineBeta adrenergic receptortarget
NortriptylineDopamine D2 receptortarget
NortriptylineSigma receptortarget
Nortriptyline5-hydroxytryptamine receptor 1Ctarget
NortriptylineSodium-dependent noradrenaline transportertransporter
NortriptylineMuscarinic acetylcholine receptortarget
NortriptylineP-glycoprotein 1transporter
AzatadineHistamine H1 receptortarget
Cyclobenzaprine5-hydroxytryptamine receptor 2Atarget
CyclobenzaprineCytochrome P450 1A2enzyme
CyclobenzaprineCytochrome P450 3A4enzyme
CyclobenzaprineCytochrome P450 2D6enzyme
CyclobenzaprineSerum albumincarrier
CyclobenzaprineUDP-glucuronosyltransferase 1-4enzyme
CyclobenzaprineUDP-glucuronosyltransferase 2B10enzyme
Cyclobenzaprine5-hydroxytryptamine receptor 2Btarget
Cyclobenzaprine5-hydroxytryptamine receptor 2Ctarget
Cyclobenzaprine5-hydroxytryptamine receptor 7target
Cyclobenzaprine5-hydroxytryptamine receptor 6target
CyclobenzaprineSodium-dependent serotonin transportertarget
CyclobenzaprineSodium-dependent noradrenaline transportertarget
CyclobenzaprineToll-like receptor 4target
CyclobenzaprineAldehyde oxidasetarget
DesloratadineHistamine H1 receptortarget
DesloratadineP-glycoprotein 1transporter
OMS-103HPTumor necrosis factortarget
OMS-103HPInterleukin-1 receptor type 1target
RupatadineCytochrome P450 3A4enzyme
RupatadineCytochrome P450 2C9enzyme
RupatadineCytochrome P450 2C19enzyme
RupatadineCytochrome P450 2D6enzyme
RupatadinePlatelet-activating factor receptortarget
RupatadineHistamine H1 receptortarget