Desloratadine is a second generation tricyclic antihistamine used to treat seasonal and non seasonal allergic rhinitis, pruritus, and urticaria. Desloratadine is a second generation, tricyclic antihistamine that which has a selective and peripheral H1-antagonist action.
- Mechanism
- Curator reviewed
Like other H1-blockers, Desloratadine competes with free histamine for binding at H1-receptors in the GI tract, uterus, large blood vessels, and bronchial smooth muscle. This blocks the action of endogenous histamine, which subsequently leads to temporary relief of the negative symptoms (eg. nasal congestion, watery eyes) brought on by histamine.
- Primary indication
- For the relief of symptoms of seasonal allergic rhinitis, perennial (non-seasonal) allergic rhinitis.Curator reviewed · 10 structured indications
- Formula / weight
- C19H19ClN2 · 310.821 g/mol (avg)
- First approval
- Canada, 2010 · United States, 2001 · European Union, 2016
- Also known as
- Descarboethoxyloratadine
- Code names
- SCH-34117
- Brand names
Resolves to
JAUOIFJMECXRGI-UHFFFAOYSA-NSMILESClC1=CC2=C(C=C1)C(=C1CCNCC1)C1=C(CC2)C=CC=N1What you can answer from here — as of September 23, 2026
Which drugs share a target with Desloratadine, and which of those have an active Phase 3 trial?
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