Free Radical Scavengers

Name
Free Radical Scavengers
Accession Number
DBCAT000864
Description

Substances that influence the course of a chemical reaction by ready combination with free radicals. Among other effects, this combining activity protects pancreatic islets against damage by cytokines and prevents myocardial and pulmonary perfusion injuries.

Drugs
DrugDrug Description
Nitric OxideA vasodilating agent used in the treatment of hypoxic respiratory failure in premature neonates.
AllopurinolA xanthine oxidase inhibitor used to reduce urinary and serum uric acid concentrations in patients with gout, recurrent calcium oxalate calculi, and various malignancies.
PentoxifyllineA methylxanthine derivative used to treat intermittent claudication caused by chronic occlusive arterial disease of the limbs.
Dimethyl sulfoxideA reversible mitogen-activated extracellular signal-regulated kinase-1 (MEK1) and MEK2 inhibitor used to treat certain types of melanoma, metastatic non-small cell lung cancer, and locally advanced or metastatic anaplastic thyroid cancer.
3-hydroxyanthranilic acidAn oxidation product of tryptophan metabolism. It may be a free radical scavenger and a carcinogen.
p-Coumaric acidNot Available
AcetylcysteineA medication that can be used as a mucolytic in patients with certain lung conditions and as an antidote for acetaminophen overdose.
Ferulic acidNot Available
AllicinAllicin has been used in trials studying the treatment of Follicular Lymphoma.
AnisodamineAnisodamine has been investigated for the treatment of Intestinal Diseases.
EdaravoneA free radical scavenger used to delay the progression of ALS.
Bisphenol ANot Available
Drugs & Drug Targets
DrugTargetType
Nitric OxideGuanylate cyclase soluble subunit alpha-2target
Nitric OxideAldehyde dehydrogenase, mitochondrialenzyme
Nitric OxideCytochrome P450 1A2enzyme
Nitric OxideCytochrome P450 2B6enzyme
Nitric OxideCytochrome P450 3A4enzyme
Nitric OxideMetallothionein-1Atarget
Nitric OxideIndoleamine 2,3-dioxygenase 1target
AllopurinolXanthine dehydrogenase/oxidasetarget
AllopurinolSolute carrier family 22 member 8transporter
AllopurinolSolute carrier family 22 member 7transporter
AllopurinolAldehyde oxidaseenzyme
AllopurinolXanthine dehydrogenase/oxidaseenzyme
AllopurinolATP-binding cassette sub-family G member 2transporter
AllopurinolSolute carrier family 22 member 2transporter
Pentoxifylline5'-nucleotidasetarget
PentoxifyllineAdenosine receptor A1target
PentoxifyllineAdenosine receptor A2atarget
PentoxifyllineCytochrome P450 1A2enzyme
PentoxifyllinePhosphodiesterase enzymestarget
Dimethyl sulfoxideTransthyretincarrier
Dimethyl sulfoxideCytochrome P450 2C19enzyme
Dimethyl sulfoxideCytochrome P450 2D6enzyme
Dimethyl sulfoxideCytochrome P450 3A4enzyme
3-hydroxyanthranilic acidTrans-2,3-dihydro-3-hydroxyanthranilate isomerasetarget
p-Coumaric acidPhotoactive yellow proteintarget
p-Coumaric acidPPHtarget
p-Coumaric acidProstaglandin reductase 1target
p-Coumaric acidHistidine ammonia-lyasetarget
AcetylcysteineSolute carrier organic anion transporter family member 1B1transporter
AcetylcysteineNAPQI (N-acetyl-p-benzoquinone imine)target
AcetylcysteineSolute carrier family 22 member 6transporter
AcetylcysteineAminoacylase-1target
AcetylcysteineInhibitor of nuclear factor kappa-B kinase subunit alphatarget
AcetylcysteineInhibitor of nuclear factor kappa-B kinase subunit betatarget
AcetylcysteineGlutathione synthetasetarget
AcetylcysteineCystine/glutamate transportertarget
AcetylcysteineGlutamate receptor ionotropic, NMDA 2Btarget
AcetylcysteineGlutamate receptor ionotropic, NMDA 1target
AcetylcysteineGlutamate receptor ionotropic, NMDA 2Atarget
AcetylcysteineGlutamate receptor ionotropic, NMDA 2Dtarget
AcetylcysteineGlutamate receptor ionotropic, NMDA 3Atarget
AcetylcysteineSerum albumincarrier
AcetylcysteineAminoacylase-1enzyme
Ferulic acidEndo-1,4-beta-xylanase Ytarget
Ferulic acidEndo-1,4-beta-xylanase Ztarget
Ferulic acidEst1etarget
Ferulic acidO-methyltransferasetarget
AnisodamineCytochrome P450 2D6enzyme
EdaravoneSolute carrier family 22 member 6transporter
EdaravoneSolute carrier family 22 member 8transporter
Bisphenol AEstrogen-related receptor gammatarget