Excitatory Amino Acid Antagonists
- Excitatory Amino Acid Antagonists
- Accession Number
Drugs that bind to but do not activate excitatory amino acid receptors, thereby blocking the actions of agonists.
Drug Drug Description Dextromethorphan An NMDA receptor antagonist used to treat cases of dry cough. Riluzole A glutamate antagonist used to treat amyotrophic lateral sclerosis. Memantine An NMDA receptor antagonist used to treat moderate to severe dementia in Alzheimer's. Phenobarbital A long-lasting barbiturate and anticonvulsant used in the treatment of all types of seizures, except for absent seizures. Ketamine A rapid-acting general anesthetic and NMDA receptor antagonist used for induction of anesthesia diagnostic and surgical procedures typically in combination with a muscle relaxant. Phencyclidine A hallucinogen formerly used as a veterinary anesthetic, and briefly as a general anesthetic for humans. Phencyclidine is similar to ketamine in structure and in many of its effects. Like... FG-9041 Not Available Ifenprodil N-methyl-D-aspartate (NMDA) receptors (NMDARs) are members of the ionotropic glutamate receptor family, with key roles in brain development and neurological function.[A220118, A220128] NMDARs are heterotetramers that typically involve a dimer... Kynurenic Acid Kynurenic Acid is under investigation in clinical trial NCT02340325 (FS2 Safety and Tolerability Study in Healthy Volunteers). Eliprodil Eliprodil has been used in trials studying the treatment of Parkinson Disease and Movement Disorders. Gacyclidine Gacyclidine has been used in trials studying the treatment of Tinnitus. Dextrorphan Not Annotated 5,7-Dichlorokynurenic acid Not Available Felbamate An anticonvulsant used to treat severe epilepsy. Dexanabinol Investigated for use/treatment in traumatic brain injuries and neurologic disorders. Ketobemidone For the treatment of all types of severe pain, such as postoperative, cancer, kidney stones and fractures. Gavestinel Highly potent and selective non-competitive antagonist acting at the strychnine-insensitive glycine binding site of the NMDA receptor-channel complex (Kd = 0.8 nM). Gavestinel displays > 1000-fold selectivity over NMDA, AMPA... Caroverine A calcium channel blocker indicated in the treatment of smooth muscle spasms, alcohol and drug withdrawal, and tinnitus.
- Drugs & Drug Targets