Organothiophosphates

Name
Organothiophosphates
Accession Number
DBCAT001123
Description

Carbon-containing thiophosphoric acid derivatives. Included under this heading are compounds that have carbon bound to either SULFUR atom, or the OXYGEN atom of the SPO3 core structure.

Drugs
DrugDrug Description
MalathionA parasympathomimetic organophosphate used to treat head lice.
EchothiophateAn acetylcholinesterase inhibitor used in ophthalmic preparations to increase the drainage of intraocular fluid; most commonly used for the treatment of glaucoma.
AmifostineA cytoprotective adjuvant used for reduction in the cumulative renal toxicity in patients with ovarian cancer and moderate to severe xerostomia in patients undergoing post-operative radiation treatment for head and neck cancer.
CoumaphosThis drug is a fat-soluble phosphorothioate agent that kills both insects and mites. It is non-volatile in nature and is well known by a variety of names as such a...
FenthionFenthion is an organothiophosphate drug used as an insecticide, avicide, and acaricide. Its mode of action is explained by cholinesterase enzyme inhibition, which is similar to other organophosphates. Fenthion is...
PhosmetPhosmet is a phthalimide-derived organophosphate. It is a non-specific insecticide. It is mainly used on apple trees to control codling moths. It is also used on other fruit crops, ornamentals,...
TemefosDiphos has been used in trials studying the treatment of Plasmodium Falciparum Malaria.
Drugs & Drug Targets
DrugTargetType
MalathionCholinesterasetarget
MalathionCytochrome P450 1A2enzyme
MalathionCytochrome P450 2B6enzyme
EchothiophateCholinesterasetarget
EchothiophateSerum albumincarrier
AmifostineAlkaline phosphatase, placental-liketarget
AmifostineAlkaline phosphatase, tissue-nonspecific isozymeenzyme