Echothiophate is an acetylcholinesterase inhibitor used in ophthalmic preparations to increase the drainage of intraocular fluid; most commonly used for the treatment of glaucoma. A potent, long-acting irreversible cholinesterase inhibitor used as an ocular hypertensive in the treatment of glaucoma.
- Mechanism
- Curator reviewed
Echothiophate Iodide is a long-acting cholinesterase inhibitor for topical use which enhances the effect of endogenously liberated acetylcholine in iris, ciliary muscle, and other parasympathetically innervated structures of the eye. Echothiophate iodide binds irreversibly to cholinesterase, and is long acting due to the slow rate of hydrolysis by cholinesterase. It causes miosis, increase in facility of outflow of aqueous humor, fall in intraocular pressure, and potentiation of accommodation.
- Primary indication
- For use in the treatment of subacute or chronic angle-closure glaucoma after iridectomy or where surgery is refused or contraindicated.Curator reviewed · 5 structured indications
- Formula / weight
- C9H23NO3PS · 256.323 g/mol (avg)
- First approval
- Canada, 1998 · United States, 1959
- Also known as
- Ecothiopate · Phospholine
- Code names
- MI 217
- Brand names
Resolves to
BJOLKYGKSZKIGU-UHFFFAOYSA-NSMILESCCOP(=O)(OCC)SCC[N+](C)(C)CWhat you can answer from here — as of September 19, 2026
Which drugs share a target with Echothiophate, and which of those have an active Phase 3 trial?
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