Antimicrobial Cationic Peptides
- Name
- Antimicrobial Cationic Peptides
- Accession Number
- DBCAT001130
- Description
Small cationic peptides that are an important component, in most species, of early innate and induced defenses against invading microbes. In animals they are found on mucosal surfaces, within phagocytic granules, and on the surface of the body. They are also found in insects and plants. Among others, this group includes the DEFENSINS, protegrins, tachyplesins, and thionins. They displace DIVALENT CATIONS from phosphate groups of MEMBRANE LIPIDS leading to disruption of the membrane.
- Drugs
Drug Drug Description Polymyxin B A polymyxin antibiotic used to treat a wide variety of infections in the body. Colistin A polymyxin antibiotic used to treat bacterial infections caused by susceptible Gram negative bacteria. Colistimethate An antibiotic indicated for treatment of infections caused by susceptible strains of certain gram-negative bacilli. It is particularly useful for targeting sensitive strains of Pseudomonas aeruginosa. P-113D For the potential treatment of cystic fibrosis and bacterial infections. - Drugs & Drug Targets
Drug Target Type Polymyxin B Bacterial outer membrane target Polymyxin B Solute carrier family 15 member 2 transporter Colistin Bacterial outer membrane target Colistimethate Bacterial outer membrane target