Antimicrobial Cationic Peptides

Name
Antimicrobial Cationic Peptides
Accession Number
DBCAT001130
Description

Small cationic peptides that are an important component, in most species, of early innate and induced defenses against invading microbes. In animals they are found on mucosal surfaces, within phagocytic granules, and on the surface of the body. They are also found in insects and plants. Among others, this group includes the DEFENSINS, protegrins, tachyplesins, and thionins. They displace DIVALENT CATIONS from phosphate groups of MEMBRANE LIPIDS leading to disruption of the membrane.

Drugs
DrugDrug Description
Polymyxin BA polymyxin antibiotic used to treat a wide variety of infections in the body.
ColistinA polymyxin antibiotic used to treat bacterial infections caused by susceptible Gram negative bacteria.
ColistimethateAn antibiotic indicated for treatment of infections caused by susceptible strains of certain gram-negative bacilli. It is particularly useful for targeting sensitive strains of Pseudomonas aeruginosa.
P-113DFor the potential treatment of cystic fibrosis and bacterial infections.
Drugs & Drug Targets
DrugTargetType
Polymyxin BBacterial outer membranetarget
Polymyxin BSolute carrier family 15 member 2transporter
ColistinBacterial outer membranetarget
ColistimethateBacterial outer membranetarget