Carbazoles

Name
Carbazoles
Accession Number
DBCAT001187
Description

Benzo-indoles similar to CARBOLINES which are pyrido-indoles. In plants, carbazoles are derived from indole and form some of the INDOLE ALKALOIDS.

Drugs
DrugDrug Description
7-HydroxystaurosporineNot Available
CarvedilolA non selective beta-adrenergic antagonist used to treat mild to severe chronic heart failure, hypertension, and left ventricular dysfunction following myocardial infarction in clinically stable patients.
EllipticineEllipticine is a potent antineoplastic agent.
MidostaurinAn antineoplastic agent used to treat high-risk acute myeloid leukemia (AML) with specific mutations, aggressive systemic mastocytosis (ASM), systemic mastocytosis with associated hematologic neoplasm (SM-AHN), or mast cell leukemia (MCL).
OndansetronA serotonin 5-HT3 receptor antagonist used to prevent nausea and vomiting in cancer chemotherapy and postoperatively.
RetelliptineRetelliptine is a small molecule drug. Retelliptine has a monoisotopic molecular weight of 404.26 Da.
StaurosporineAn indolocarbazole that is a potent protein kinase C inhibitor which enhances cAMP-mediated responses in human neuroblastoma cells. (Biochem Biophys Res Commun 1995;214(3):1114-20)
Drugs & Drug Targets
DrugTargetType
7-Hydroxystaurosporine3-phosphoinositide-dependent protein kinase 1target
7-HydroxystaurosporineProtein kinase Ctarget
7-HydroxystaurosporineCyclin-dependent kinase 6target
7-HydroxystaurosporineCyclin-dependent kinase 4target
7-HydroxystaurosporineCyclin-dependent kinase 2target
7-HydroxystaurosporineSerine/threonine-protein kinase Chk1target
CarvedilolCytochrome P450 2E1enzyme
CarvedilolAlpha-1 adrenergic receptorstarget
CarvedilolBeta adrenergic receptortarget
CarvedilolInward rectifier potassium channel 2target
CarvedilolUDP-glucuronosyltransferase 2B7enzyme
CarvedilolUDP-glucuronosyltransferase 2B4enzyme
CarvedilolAlbumincarrier
CarvedilolUDP-glucuronosyltransferase 1A1enzyme
CarvedilolInward rectifier potassium channel 4target
CarvedilolHypoxia-inducible factor 1-alphatarget
CarvedilolE-selectintarget
CarvedilolAlpha-2A adrenergic receptortarget
CarvedilolAlpha-2B adrenergic receptortarget
CarvedilolAlpha-2C adrenergic receptortarget
CarvedilolAlpha-1B adrenergic receptortarget
CarvedilolAlpha-1D adrenergic receptortarget
CarvedilolCytochrome P450 1A1enzyme
CarvedilolCytochrome P450 3A4enzyme
CarvedilolCytochrome P450 1A2enzyme
CarvedilolATP-dependent translocase ABCB1transporter
CarvedilolXanthine dehydrogenase/oxidaseenzyme
CarvedilolCytochrome P450 2D6enzyme
CarvedilolAlpha-1A adrenergic receptortarget
CarvedilolBeta-1 adrenergic receptortarget
CarvedilolNADH dehydrogenase [ubiquinone] 1 subunit C2target
CarvedilolBeta-2 adrenergic receptortarget
CarvedilolVascular endothelial growth factor A, long formtarget
CarvedilolNatriuretic peptides Btarget
CarvedilolGap junction alpha-1 proteintarget
CarvedilolVoltage-gated inwardly rectifying potassium channel KCNH2target
CarvedilolVascular cell adhesion protein 1target
CarvedilolCytochrome P450 2C9enzyme
EllipticineDNA topoisomerase 2-betatarget
EllipticineDNA topoisomerase 2-alphatarget
MidostaurinProtein kinase Ctarget
MidostaurinProtein kinase C gamma typetarget
MidostaurinCytochrome P450 3A43enzyme
MidostaurinCytochrome P450 3A7enzyme
MidostaurinCytochrome P450 3A5enzyme
MidostaurinCytochrome P450 3A4enzyme
MidostaurinCytochrome P450 2E1enzyme
MidostaurinCytochrome P450 2D6enzyme
MidostaurinCytochrome P450 2C19enzyme
MidostaurinCytochrome P450 2C9enzyme
MidostaurinCytochrome P450 2C8enzyme
MidostaurinCytochrome P450 2B6enzyme
MidostaurinCytochrome P450 1A2enzyme
MidostaurinCytochrome P450 3A Subfamilyenzyme
MidostaurinReceptor-type tyrosine-protein kinase FLT3target
MidostaurinPlatelet-derived growth factor receptor betatarget
MidostaurinPlatelet-derived growth factor receptor alphatarget
MidostaurinMast/stem cell growth factor receptor Kittarget
MidostaurinVascular endothelial growth factor receptor 2target
MidostaurinProtein kinase C alpha typetarget
Ondansetron5-hydroxytryptamine receptor 4target
OndansetronCytochrome P450 3A7enzyme
OndansetronCytochrome P450 3A5enzyme
Ondansetron5-hydroxytryptamine receptor 3Atarget
OndansetronCytochrome P450 1A2enzyme
OndansetronCytochrome P450 3A4enzyme
Ondansetron5-hydroxytryptamine receptor 1Atarget
Ondansetron5-hydroxytryptamine receptor 1Btarget
OndansetronMu-type opioid receptortarget
OndansetronCytochrome P450 2C9enzyme
OndansetronCytochrome P450 2E1enzyme
OndansetronCytochrome P450 2D6enzyme
StaurosporineTyrosine-protein kinase Lcktarget
StaurosporineSerine/threonine-protein kinase pim-1target
StaurosporineTyrosine-protein kinase ITK/TSKtarget
StaurosporineTyrosine-protein kinase SYKtarget
StaurosporineMAP kinase-activated protein kinase 2target
StaurosporineGlycogen synthase kinase-3 betatarget
StaurosporineTyrosine-protein kinase CSKtarget
StaurosporineCyclin-dependent kinase 2target
StaurosporinePhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoformtarget
Staurosporine3-phosphoinositide-dependent protein kinase 1target
StaurosporineInhibitor of nuclear factor kappa-B kinase subunit betatarget
StaurosporineProtein kinase C theta typetarget
StaurosporineTyrosine-protein kinase ZAP-70target
StaurosporineATP-dependent translocase ABCB1transporter
StaurosporineMuscarinic acetylcholine receptor M1target
StaurosporineProtein kinase Ctarget