Uricosuric Agents

All categories
Name
Uricosuric Agents
Accession Number
DBCAT001241
Description

Gout suppressants that act directly on the renal tubule to increase the excretion of uric acid, thus reducing its concentrations in plasma.

Drugs
DrugDrug Description
AllopurinolA xanthine oxidase inhibitor used to reduce urinary and serum uric acid concentrations in patients with gout, recurrent calcium oxalate calculi, and various malignancies.
AzapropazoneNot Available
BenzbromaroneA uricosuric agent which is taken daily for the prevention of gout flares.
BenziodaroneBenziodarone is a uricostatic and a uricosuric agent which is sold also under the name Amplivex-Labaz. It is used in the treatment of gout . It was withdrawn from France...
DotinuradDotinurad is under investigation in clinical trial NCT03372200 (Febuxostat-controlled, Double-blind, Comparative Study of FYU-981 in Hyperuricemia With or Without Gout).
LesinuradA uric acid 1 transporter inhibitor typically used in combination with a xanthine oxidase inhibitor to treat hyperuricemia associated with gout in patients with inadequate control of uric acid levels with xanthine oxidase inhibitor monotherapy.
ProbenecidA medication used to treat gouty arthritis, tophaceous gout, and hyperuricemia.
SulfinpyrazoneA platelet inhibitory and uricosuric agent used to inhibit thrombotic and embolic processes and to manage the chronic phases of gout .
Tienilic acidFor the treatment of hypertension.
TraxanoxTraxanox is a small molecule drug. Traxanox has a monoisotopic molecular weight of 299.02 Da.
ZoxazolamineNot Annotated
Drugs & Drug Targets
DrugTargetType
AllopurinolCytochrome P450 1A2enzyme
AllopurinolSolute carrier family 22 member 2transporter
AllopurinolBroad substrate specificity ATP-binding cassette transporter ABCG2transporter
AllopurinolXanthine dehydrogenase/oxidaseenzyme
AllopurinolAldehyde oxidaseenzyme
AllopurinolSolute carrier family 22 member 7transporter
AllopurinolOrganic anion transporter 3transporter
AllopurinolXanthine dehydrogenase/oxidasetarget
AzapropazoneHuman Cyclooxygenasestarget
AzapropazoneAlbumincarrier
BenzbromaroneCytochrome P450 2C19target
BenzbromaroneSolute carrier family 22 member 12target
BenzbromaroneAnoctamin-1target
BenzbromaroneMultidrug resistance-associated protein 1target
BenzbromaroneCytochrome P450 2C19enzyme
BenzbromaroneBile salt export pumptransporter
BenzbromaroneCytochrome P450 2C9target
BenzbromaroneSolute carrier organic anion transporter family member 1B1transporter
BenzbromaroneSolute carrier organic anion transporter family member 2B1transporter
BenziodaroneCalmodulin-1target
DotinuradSolute carrier family 22 member 12target
LesinuradCytochrome P450 3A4enzyme
LesinuradCytochrome P450 2C9enzyme
LesinuradSolute carrier family 22 member 11target
LesinuradSolute carrier family 22 member 12target
ProbenecidOrganic cation/carnitine transporter 2transporter
ProbenecidATP-binding cassette sub-family C member 6transporter
ProbenecidMultidrug resistance-associated protein 1transporter
ProbenecidSolute carrier organic anion transporter family member 1C1transporter
ProbenecidMonocarboxylate transporter 1transporter
ProbenecidHepatic sodium/bile acid cotransportertransporter
ProbenecidSolute carrier family 22 member 6transporter
ProbenecidSolute carrier family 22 member 10transporter
ProbenecidOrganic anion transporter 3transporter
ProbenecidATP-binding cassette sub-family C member 2transporter
ProbenecidATP-binding cassette sub-family C member 11transporter
ProbenecidSolute carrier family 22 member 11transporter
ProbenecidMonocarboxylate transporter 2transporter
ProbenecidSolute carrier family 22 member 7transporter
ProbenecidSolute carrier family 22 member 6target
ProbenecidPannexin-1target
ProbenecidCytochrome P450 2C8enzyme
ProbenecidCytochrome P450 3A4enzyme
ProbenecidSolute carrier family 22 member 12transporter
ProbenecidSolute carrier family 2, facilitated glucose transporter member 9transporter
ProbenecidTaste receptor type 2 member 16target
ProbenecidUDP-glucuronosyltransferase 1A1enzyme
ProbenecidCytochrome P450 2C9enzyme
ProbenecidATP-binding cassette sub-family C member 5transporter
ProbenecidATP-binding cassette sub-family C member 4transporter
ProbenecidATP-binding cassette sub-family C member 3transporter
ProbenecidSolute carrier family 22 member 1transporter
ProbenecidSolute carrier family 22 member 2transporter
ProbenecidAlbumincarrier
ProbenecidSolute carrier family 22 member 11target
ProbenecidOrganic anion transporter 3target
ProbenecidSolute carrier organic anion transporter family member 1A2transporter
SulfinpyrazoneMultidrug resistance-associated protein 1target
SulfinpyrazoneBile salt export pumptransporter
SulfinpyrazoneNuclear receptor subfamily 1 group I member 2target
SulfinpyrazoneSolute carrier family 22 member 12target
SulfinpyrazoneCytochrome P450 2C8enzyme
SulfinpyrazoneCytochrome P450 2B6enzyme
SulfinpyrazoneCytochrome P450 3A4enzyme
SulfinpyrazoneATP-binding cassette sub-family C member 2transporter
SulfinpyrazoneMultidrug resistance-associated protein 1transporter
SulfinpyrazoneATP-binding cassette sub-family C member 6transporter
SulfinpyrazoneATP-binding cassette sub-family C member 5transporter
SulfinpyrazoneATP-binding cassette sub-family C member 4transporter
SulfinpyrazoneATP-binding cassette sub-family C member 3transporter
SulfinpyrazoneCytochrome P450 2C9enzyme
SulfinpyrazoneFatty acid-binding protein, intestinalcarrier
SulfinpyrazoneATP-binding cassette sub-family C member 2target
Tienilic acidCytochrome P450 2C9enzyme
ZoxazolamineSmall conductance calcium-activated potassium channel protein 2target