Uricosuric Agents

Name
Uricosuric Agents
Accession Number
DBCAT001241
Description

Gout suppressants that act directly on the renal tubule to increase the excretion of uric acid, thus reducing its concentrations in plasma.

Drugs
DrugDrug Description
SulfinpyrazoneA platelet inhibitory and uricosuric agent used to inhibit thrombotic and embolic processes and to manage the chronic phases of gout .
ProbenecidA medication used to treat gouty arthritis, tophaceous gout, and hyperuricemia.
Tienilic acidFor the treatment of hypertension.
AzapropazoneNot Available
LesinuradA uric acid 1 transporter inhibitor typically used in combination with a xanthine oxidase inhibitor to treat hyperuricemia associated with gout in patients with inadequate control of uric acid levels with xanthine oxidase inhibitor monotherapy.
BenzbromaroneA uricosuric agent which is taken daily for the prevention of gout flares.
BenziodaroneBenziodarone is a uricostatic and a uricosuric agent which is sold also under the name Amplivex-Labaz. It is used in the treatment of gout . It was withdrawn from France...
AllopurinolA xanthine oxidase inhibitor used to reduce urinary and serum uric acid concentrations in patients with gout, recurrent calcium oxalate calculi, and various malignancies.
Drugs & Drug Targets
DrugTargetType
SulfinpyrazoneMultidrug resistance-associated protein 1target
SulfinpyrazoneCanalicular multispecific organic anion transporter 1target
SulfinpyrazoneFatty acid-binding protein, intestinalcarrier
SulfinpyrazoneCytochrome P450 2C9enzyme
SulfinpyrazoneCanalicular multispecific organic anion transporter 2transporter
SulfinpyrazoneMultidrug resistance-associated protein 4transporter
SulfinpyrazoneMultidrug resistance-associated protein 5transporter
SulfinpyrazoneMultidrug resistance-associated protein 6transporter
SulfinpyrazoneMultidrug resistance-associated protein 1transporter
SulfinpyrazoneCanalicular multispecific organic anion transporter 1transporter
SulfinpyrazoneCytochrome P450 3A4enzyme
SulfinpyrazoneCytochrome P450 2B6enzyme
SulfinpyrazoneCytochrome P450 2C8enzyme
SulfinpyrazoneSolute carrier family 22 member 12target
SulfinpyrazoneNuclear receptor subfamily 1 group I member 2target
SulfinpyrazoneBile salt export pumptransporter
ProbenecidSolute carrier family 22 member 8target
ProbenecidSolute carrier family 22 member 11target
ProbenecidSerum albumincarrier
ProbenecidSolute carrier family 22 member 2transporter
ProbenecidSolute carrier family 22 member 1transporter
ProbenecidCanalicular multispecific organic anion transporter 2transporter
ProbenecidMultidrug resistance-associated protein 4transporter
ProbenecidMultidrug resistance-associated protein 5transporter
ProbenecidMonocarboxylate transporter 2transporter
ProbenecidSolute carrier family 22 member 5transporter
ProbenecidMultidrug resistance-associated protein 6transporter
ProbenecidMultidrug resistance-associated protein 1transporter
ProbenecidSolute carrier organic anion transporter family member 1A2transporter
ProbenecidMonocarboxylate transporter 1transporter
ProbenecidSodium/bile acid cotransportertransporter
ProbenecidSolute carrier family 22 member 6transporter
ProbenecidSolute carrier family 22 member 10transporter
ProbenecidSolute carrier family 22 member 8transporter
ProbenecidCanalicular multispecific organic anion transporter 1transporter
ProbenecidATP-binding cassette sub-family C member 11transporter
ProbenecidSolute carrier family 22 member 11transporter
ProbenecidSolute carrier organic anion transporter family member 1C1transporter
ProbenecidSolute carrier family 22 member 7transporter
ProbenecidSolute carrier family 22 member 6target
ProbenecidPannexin-1target
ProbenecidCytochrome P450 2C8enzyme
ProbenecidCytochrome P450 3A4enzyme
ProbenecidSolute carrier family 22 member 12transporter
ProbenecidSolute carrier family 2, facilitated glucose transporter member 9transporter
ProbenecidTaste receptor type 2 member 16target
ProbenecidUDP-glucuronosyltransferase 1-1enzyme
ProbenecidCytochrome P450 2C9enzyme
Tienilic acidCytochrome P450 2C9enzyme
AzapropazoneSerum albumincarrier
LesinuradSolute carrier family 22 member 12target
LesinuradSolute carrier family 22 member 11target
LesinuradCytochrome P450 2C9enzyme
LesinuradCytochrome P450 3A4enzyme
BenzbromaroneCytochrome P450 2C9target
BenzbromaroneCytochrome P450 2C19target
BenzbromaroneSolute carrier organic anion transporter family member 1B1transporter
BenzbromaroneSolute carrier organic anion transporter family member 2B1transporter
BenzbromaroneBile salt export pumptransporter
BenzbromaroneCytochrome P450 2C19enzyme
AllopurinolXanthine dehydrogenase/oxidasetarget
AllopurinolSolute carrier family 22 member 8transporter
AllopurinolSolute carrier family 22 member 7transporter
AllopurinolAldehyde oxidaseenzyme
AllopurinolXanthine dehydrogenase/oxidaseenzyme
AllopurinolATP-binding cassette sub-family G member 2transporter
AllopurinolSolute carrier family 22 member 2transporter