Marine Toxins

Name
Marine Toxins
Accession Number
DBCAT001494
Description

Toxic or poisonous substances elaborated by marine flora or fauna. They include also specific, characterized poisons or toxins for which there is no more specific heading, like those from poisonous FISHES.

Drugs
DrugDrug Description
ZiconotideAn N-type calcium channel antagonist used to manage patients with severe chronic pain who cannot tolerate, or who have not responded adequately to other treatments such as intrathecal morphine and systemic analgesics.
TetrodotoxinFor the treatment of chronic and breakthrough pain in advanced cancer patients as well as for the treatment of opioid dependence.
alpha-Conotoxin VC 1.1Investigated for use/treatment in pain (acute or chronic).
NeosaxitoxinNeosaxitoxin is under investigation in clinical trial NCT01786655 (Safety Study of Long-Acting Local Anesthetic).
Bryostatin 1Bryostatin 1 has been investigated for the treatment of HIV Infection and Alzheimer's Disease.
Drugs & Drug Targets
DrugTargetType
ZiconotideVoltage-dependent N-type calcium channel subunit alpha-1Btarget
ZiconotideVoltage-dependent P/Q-type calcium channel subunit alpha-1Atarget
TetrodotoxinSodium channel protein type 1 subunit alphatarget
TetrodotoxinSodium channel protein type 2 subunit alphatarget
TetrodotoxinSodium channel protein type 3 subunit alphatarget
TetrodotoxinSodium channel protein type 8 subunit alphatarget
Bryostatin 1Cytochrome P450 3A4enzyme
Bryostatin 1Protein kinase C alpha typetarget
Bryostatin 1Protein kinase C epsilon typetarget
Bryostatin 1Caspase-8target
Bryostatin 1Protein unc-13 homolog Btarget
Bryostatin 1Serine/threonine-protein kinase D1target
Bryostatin 1T-lymphocyte activation antigen CD86target
Bryostatin 1Prostaglandin G/H synthase 2target
Bryostatin 1G1/S-specific cyclin-D1target
Bryostatin 1Tumor necrosis factortarget