Antiarrhythmics, Class III

Name
Antiarrhythmics, Class III
Accession Number
DBCAT002208  (DBCAT003659)
Description

Delay repolarization (phase 3) and thereby increase action potential duration and effective refractory period.

ATC Classification
Drugs
DrugDrug Description
DofetilideA class III antiarrhythmic drug used for the maintenance of normal sinus rhythm and cardioversion in cases of atrial fibrillation and atrial flutter.
IbutilideA class III antiarrhythmic agent used to correct atrial fibrillation and atrial flutter, which can be considered as an alternative to cardioversion.
AmiodaroneA class III antiarrhythmic indicated for the treatment of recurrent hemodynamically unstable ventricular tachycardia and recurrent ventricular fibrillation.
DronedaroneAn antiarrhythmic agent used in the reduce the risk of hospitalization in patients with paroxysmal or persistent atrial fibrillation.
TedisamilInvestigated for use/treatment in arrhythmia, atrial fibrillation, and angina.
BunaftineNot Annotated
BretyliumA norepinephrine release inhibitor used for the prophylaxis and therapy of ventricular fibrillation, as well as the treatment of life-threatening ventricular arrhythmias.
VernakalantAn antiarrhythmic medication used to treat patients with atrial fibrillation.
AzimilideInvestigated for use/treatment in arrhythmia and atrial fibrillation.
Drugs & Drug Targets
DrugTargetType
DofetilidePotassium channel subfamily K member 2target
DofetilidePotassium voltage-gated channel subfamily H member 2target
DofetilideATP-sensitive inward rectifier potassium channel 12target
DofetilideCytochrome P450 3A4enzyme
DofetilideSolute carrier family 22 member 2transporter
IbutilidePotassium voltage-gated channel subfamily H member 6target
IbutilideVoltage-dependent L-type calcium channel subunit beta-1target
IbutilideVoltage-dependent calcium channel gamma-1 subunittarget
IbutilideVoltage-dependent calcium channel subunit alpha-2/delta-1target
IbutilidePotassium voltage-gated channel subfamily H member 2target
IbutilideVoltage-dependent L-type calcium channel subunit alpha-1Ctarget
IbutilidePotassium channel subfamily K member 1target
IbutilidePotassium channel subfamily K member 6target
IbutilideATP-sensitive inward rectifier potassium channel 11target
IbutilidePotassium voltage-gated channel subfamily H member 7target
AmiodaroneBeta adrenergic receptortarget
AmiodaroneHERG human cardiac K+ channeltarget
AmiodaroneCytochrome P450 2C8enzyme
AmiodaroneCytochrome P450 2C9enzyme
AmiodaroneCytochrome P450 2D6enzyme
AmiodaroneVoltage-dependent T-type calcium channel subunit alpha-1Itarget
AmiodaroneVoltage gated L-type calcium channeltarget
AmiodaroneCytochrome P450 3A4enzyme
AmiodaroneCytochrome P450 1A2enzyme
AmiodaroneCytochrome P450 1A1enzyme
AmiodaroneP-glycoprotein 1transporter
AmiodaroneCytochrome P450 2C19enzyme
AmiodaroneCytochrome P450 2A6enzyme
AmiodaroneThyroid hormone receptortarget
AmiodaronePeroxisome proliferator-activated receptor gammatarget
AmiodaroneBile salt export pumptransporter
AmiodaroneSolute carrier family 22 member 2transporter
AmiodaroneCytochrome P450 2J2enzyme
AmiodaronePeroxisome proliferator-activated receptor alphatarget
AmiodaronePeroxisome proliferator-activated receptor gamma coactivator 1-betatarget
AmiodaroneSerum albumincarrier
DronedaroneAlpha-1A adrenergic receptortarget
DronedaroneBeta-1 adrenergic receptortarget
DronedaroneAlpha-1B adrenergic receptortarget
DronedaroneAlpha-1D adrenergic receptortarget
DronedaroneAlpha-2A adrenergic receptortarget
DronedaroneAlpha-2B adrenergic receptortarget
DronedaroneAlpha-2C adrenergic receptortarget
DronedaronePotassium voltage-gated channel subfamily H member 2target
DronedaroneVoltage-dependent L-type calcium channel subunit alpha-1Ctarget
DronedaroneVoltage-dependent L-type calcium channel subunit alpha-1Dtarget
DronedaroneVoltage-dependent L-type calcium channel subunit alpha-1Ftarget
DronedaroneVoltage-dependent L-type calcium channel subunit alpha-1Starget
DronedaroneVoltage-dependent L-type calcium channel subunit beta-1target
DronedaroneVoltage-dependent L-type calcium channel subunit beta-2target
DronedaroneVoltage-dependent L-type calcium channel subunit beta-3target
DronedaroneVoltage-dependent L-type calcium channel subunit beta-4target
DronedaroneCytochrome P450 2D6enzyme
DronedaroneCytochrome P450 3A4enzyme
DronedaroneP-glycoprotein 1transporter
DronedaronePotassium channel subfamily K member 2target
DronedaroneSerum albumincarrier
DronedaroneSolute carrier family 22 member 2transporter
DronedaroneSolute carrier family 22 member 1transporter
DronedaroneSolute carrier organic anion transporter family member 1B1transporter
DronedaroneSolute carrier organic anion transporter family member 1B3transporter
DronedaroneSolute carrier family 22 member 8transporter
DronedaroneCytochrome P450 3A5enzyme
DronedaroneCytochrome P450 2J2enzyme
DronedaroneThyroid hormone receptor alphatarget
DronedaroneSodium channel protein type 5 subunit alphatarget
DronedaroneG protein-activated inward rectifier potassium channel 1target
DronedaronePotassium voltage-gated channel subfamily KQT member 1target
DronedaroneInward rectifier potassium channeltarget
DronedaroneSodium/calcium exchanger 1target
DronedaronePotassium voltage-gated channel subfamily D member 3target
BretyliumSodium/potassium-transporting ATPase subunit alpha-1target
VernakalantCytochrome P450 2D6enzyme
VernakalantSodium channel protein type 5 subunit alphatarget
VernakalantPotassium voltage-gated channel subfamily A member 5target
VernakalantPotassium voltage-gated channel subfamily D member 3target
VernakalantPotassium voltage-gated channel subfamily H member 2target
AzimilidePotassium voltage-gated channel subfamily E member 1target
AzimilidePotassium voltage-gated channel subfamily KQT member 1target
AzimilidePotassium voltage-gated channel subfamily H member 2target
AzimilideCytochrome P450 1A1enzyme
AzimilideCytochrome P450 3A4enzyme
AzimilideCytochrome P450 3A5enzyme
AzimilideCytochrome P450 2D6enzyme