- Antiarrhythmic agents
- Accession Number
- DBCAT003297 (DBCAT000520)
Agents used for the treatment or prevention of cardiac arrhythmias. They may affect the polarization-repolarization phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibers. Anti-arrhythmia agents are often classed into four main groups according to their mechanism of action: sodium channel blockade, beta-adrenergic blockade, repolarization prolongation, or calcium channel blockade.
Drug Drug Description Metoprolol A beta-blocker used in the treatment of hypertension and angina, and used to reduce mortality due to myocardial infarction. Atenolol A synthetic beta-1 selective blocker used in the management of hypertension and chronic angina, and to reduce mortality in known or suspected myocardial infarction in hemodynamically stable patients. Timolol A non-selective beta adrenergic blocker used in the treatment of elevated intraocular pressure in ocular hypertension or open angle glaucoma. Digoxin A cardiac glycoside used in the treatment of mild to moderate heart failure and for ventricular response rate control in chronic atrial fibrillation. Acetyldigitoxin Used for fast digitalization in congestive heart failure. Carteolol A beta adrenergic antagonist used to treat arrhythmia, angina, hypertension, and glaucoma. Propranolol A non-selective beta adrenergic antagonist used to treat hypertension, angina, atrial fibrillation, myocardial infarction, migraine, essential tremor, hypertrophic subaortic stenosis, and pheochromocytoma. Atropine A muscarinic antagonist used to treat poisoning by muscarinic agents, including organophosphates and other drugs. Adenosine A medication used in myocardial perfusion scintigraphy and to treat supraventricular tachycardia. Magnesium sulfate A drug used to treat convulsions during pregnancy, nephritis in children, magnesium deficiency, and tetany. Verapamil A non-dihydropyridine calcium channel blocker used in the treatment of angina, arrhythmia, and hypertension. Losartan An angiotensin receptor blocker used to treat hypertension and diabetic nephropathy, and is used to reduce the risk of stroke. Moricizine An antiarrhythmic used to treat arrhythmias. Alprenolol For the treatment of hypertension, angina, and arrhythmia Levosimendan A calcium sensitizer indicated to treat acutely decompensated severe chronic heart failure. Hyoscyamine An anticholinergic indicated to treat functional gastrointestinal disorders, biliary and renal colic, and acute rhinitis. Felodipine A calcium channel blocker used to treat hypertension. Tocainide An orally active class 1b antiarrhythmic agent that interferes with cardiac sodium channels and typically used to treat ventricular arrhythmias. Deslanoside For the treatment and management of Congestive cardiac insufficiency, arrhythmias and heart failure. Bretylium A norepinephrine release inhibitor used for the prophylaxis and therapy of ventricular fibrillation, as well as the treatment of life-threatening ventricular arrhythmias. Acebutolol A selective β1-receptor antagonist used for the management of hypertension and ventricular premature beats in adults. Nadolol A non-selective beta-adrenergic antagonist used for the management of arrhythmias, angina pectoris, and hypertension. Metipranolol A beta-adrenergic antagonist used for the reduction of elevated intraocular pressure in patients with ocular hypertension or open-angle glaucoma. Encainide A voltage-gated sodium channel blocker used for management of atrial or ventricular fibrillation, atrial flutter, and ventricular tachycardia, that is no longer used due to proarrhythmic adverse effects. Bepridil For the treatment of hypertension, and chronic stable angina (classic effort-associated angina). Practolol Used in the emergency treatment of cardiac arrhythmias. Digitoxin A cardiac glycoside used in the treatment and management of congestive cardiac insufficiency, arrhythmias and heart failure. Ajmaline An antiarrhythmic used to manage a variety of forms of tachycardias. Aprindine Aprindine is a cardiac depressant used in arrhythmias. Oxprenolol A non-selective beta-adrenergic antagonist used to treat hypertension, angina pectoris, arrhythmias, and anxiety. Celiprolol A beta-blocker for the management of hypertension and angina pectoris. Azimilide Investigated for use/treatment in arrhythmia and atrial fibrillation. Tedisamil Investigated for use/treatment in arrhythmia, atrial fibrillation, and angina. Cariporide Investigated for use/treatment in cardiac surgery. Sparteine Sparteine is a plant alkaloid derived from Cytisus scoparius and Lupinus mutabilis which may chelate calcium and magnesium. It is a sodium channel blocker, so it falls in the category... Bupranolol Used to manage hypertension and tachycardia. Also used to treat glaucoma. Indenolol Indenolol is a drug of the beta-adrenergic blocker class. Nicorandil A vasodilatory drug that functions through potassium channels and intracellular cGMP concentrations commonly used to treat angina. Melperone An atypical butyrophenone antipsychotic used to treat sleep disorders, confusion, and psychomotor dysfunction associated with geriatric, psychiatric, and alcohol-dependent patients. Tropisetron A 5HT-3 receptor antagonist used as an antiemetic in the treatment of chemotherapy-induced nausea and vomiting. Talinolol Talinolol has been investigated for the basic science of Gastrointestinal Motility Disorder. Anisodamine Anisodamine has been investigated for the treatment of Intestinal Diseases. Tetrahydropalmatine Tetrahydropalmatine is under investigation in clinical trial NCT02118610 (Treatment of Schizophrenia With L-tetrahydropalmatine (l-THP): a Novel Dopamine Antagonist With Anti-inflammatory and Antiprotozoal Activity). Landiolol An ultra short-acting selective beta-blocker used for rapid ventricular rate control in cases of supraventricular tachycardia. Simendan Simendan is under investigation in clinical trial NCT00527059 (Renal Effects of Levosimendan in Patients Admitted With Acute Decompensated Heart Failure). Spiradoline Spiradoline has been investigated for the basic science of Bipolar Depression. Pilsicainide Pilsicainide has been investigated for the treatment of Paroxysmal Atrial Fibrillation. Cicletanine Cicletanine is under investigation for the treatment of Diabetes, Hypokalemia, Hyponatremia, and Arterial Hypertension. Cymarin Not Annotated Cibenzoline Not Annotated Metildigoxin A digitalis glycoside indicated in the treatment of acute and chronic heart failure. Nizofenone Not Annotated Prajmaline Not Annotated Tiracizine Not Annotated Ethacizine Not Annotated Lorajmine Not Annotated Bunaftine Not Annotated Lorcainide Not Annotated Acetyldigoxin Not Annotated Hydroquinine Not Annotated Tertatolol Tertatolol is a beta blocker. Fosfructose A phosphorylated form of fructose indicated in the treatment of hypophosphatemia. Dofetilide A class III antiarrhythmic drug used for the maintenance of normal sinus rhythm and cardioversion in cases of atrial fibrillation and atrial flutter. Disopyramide A class 1A antiarrhythmic agent used to treat life-threatening ventricular arrhythmias. Lidocaine A local anesthetic used in a wide variety of superficial and invasive procedures. Ibutilide A class III antiarrhythmic agent used to correct atrial fibrillation and atrial flutter, which can be considered as an alternative to cardioversion. Mexiletine A class 1B antiarrhythmic agent used in the treatment of documented ventricular arrhythmias that warrant treatment. Sotalol A methane sulfonanilide beta adrenergic antagonist used to treat life-threatening ventricular arrhythmias and to maintain sinus rhythm in atrial fibrillation or flutter. Quinidine A medication used to restore normal sinus rhythm, treat atrial fibrillation and flutter, and treat ventricular arrhythmias. Procainamide A medication used to treat life threatening ventricular arrhythmias. Amiodarone A class III antiarrhythmic indicated for the treatment of recurrent hemodynamically unstable ventricular tachycardia and recurrent ventricular fibrillation. Propafenone A Class 1C antiarrhythmic agent used in the management of paroxysmal atrial fibrillation/flutter and ventricular arrhythmias. Flecainide A class Ic antiarrhythmic agent used to manage atrial fibrillation and paroxysmal supraventricular tachycardias (PSVT). Dronedarone An antiarrhythmic agent used in the reduce the risk of hospitalization in patients with paroxysmal or persistent atrial fibrillation. Vernakalant An antiarrhythmic medication used to treat patients with atrial fibrillation. Isradipine A dihydropyridine calcium channel blocker used for the treatment of hypertension. Diltiazem A calcium channel blocker used to treat hypertension and to manage chronic stable angina. Nimodipine A calcium channel blocker used to improve neurological outcomes in patients with subarachnoid hemorrhage due to a ruptured intracranial aneurysm. Nisoldipine A calcium channel blocker used as monotherapy or combined with other drugs for the treatment of hypertension. Nicardipine A calcium channel blocker used for the short-term treatment of hypertension and chronic stable angina. Perhexiline For the management of severe angina pectoris. Nifedipine A dihydropyridine calcium channel blocker indicated for the management of several subtypes of angina pectoris, and hypertension. Mibefradil For the treatment of angina and high blood pressure. Clevidipine A dihydropyridine L-type calcium channel blocker used to lower blood pressure when oral antihypertensive therapy is not feasible or not desirable. Nilvadipine A calcium channel blocker used to manage arterial hypertension. Fendiline Fendiline is a coronary vasodilator which inhibits calcium function in muscle cells in excitation-contraction coupling. It has been proposed as an antiarrhythmic and antianginal agent. Fendiline is non-selective. Barnidipine A calcium channel blocker used to treat various forms of hypertension. Benidipine A synthetic dihydropyridine calcium channel blocker used to treat hypertension and angina pectoris. Cilnidipine A dihydropyridine calcium channel blocker with action on both N- and L-type calcium channels used to treat hypertension. Lacidipine A lipophilic dihydropyridine calcium channel blocker with a slow onset of action used to treat hypertension. Gallopamil Gallopamil has been used in trials studying the treatment of Asthma. Lidoflazine Not Annotated Amlodipine A calcium channel blocker used to treat hypertension and angina. Lercanidipine A calcium channel blocker for the management of hypertension. Lamotrigine A phenyltriazine antiepileptic used to treat some types of epilepsy and bipolar I disorder. Cinnarizine A drug used for the management of labyrinthine disorder symptoms, including vertigo, tinnitus, nystagmus, nausea, and vomiting. Nitrendipine A dihydropyridine calcium channel blocker indicated in the treatment of arterial hypertension. Flunarizine A selective calcium-entry blocker used as migraine prophylaxis in patients with severe and frequent episodes who have not responded adequately to more common treatments. Pinaverium A spasmolytic agent used for the symptomatic treatment of irritable bowel syndrome (IBS) and functional disorders of the biliary tract. Manidipine A dihydropyridine calcium channel blocker used to treat hypertension. Efonidipine For the treatment of hypertension. Nimesulide A cyclooxygenase 2 inhibitor used to treat acute pain and primary dysmenorrhea. Prenylamine Prenylamine was withdrawn from the Canadian, US, and UK markets in 1988 due to concerns regarding cardiac arrhythmias. Ziconotide An N-type calcium channel antagonist used to manage patients with severe chronic pain who cannot tolerate, or who have not responded adequately to other treatments such as intrathecal morphine and systemic analgesics. Dotarizine A calcium antagonist used to treat and prevent migraines. Tranilast For the treatment of bronchial asthma, keloid and hypertrophic scar, and allergic disorders such as asthma, allergic rhinitis and atopic dermatitis. Eperisone An antispasmodic that functions through voltage-gated channel blockade, notably with little to no sedation, effective in relaxing skeletal muscles and vascular smooth muscles. Azelnidipine For the treatment of hypertension. Darodipine Darodipine is a calcium channel blocker. Niguldipine Niguldipine is a calcium channel blocker drug (CCB) with a1-adrenergic antagonist properties. Niludipine Niludipine is a calcium channel blocker. Carboxyamidotriazole Carboxyamidotriazole has been used in trials studying the treatment of Lymphoma, Lung Cancer, Breast Cancer, Kidney Cancer, and Ovarian Cancer, among others. Naftopidil Naftopidil has been investigated for the treatment of Disorder of Urinary Stent. Vinpocetine A synthetic derivative of a vinca alkaloid used to treat neurological symptoms of cerebrovascular disease. Bencyclane A vasodilator agent found to be effective in a variety of peripheral circulation disorders. It has various other potentially useful pharmacological effects. Its mechanism may involve block of calcium channels. Otilonium A spasmolytic medication used to treat irritable bowel syndrome (IBS). Terodiline Not Annotated Caroverine A calcium channel blocker indicated in the treatment of smooth muscle spasms, alcohol and drug withdrawal, and tinnitus. WIN 55212-2 WIN 55,212-2 is a chemical described as an aminoalkylindole derivative, which produces effects similar to those of cannabinoids such as tetrahydrocannabinol (THC) but has an entirely different chemical structure. It... Seletracetam Investigated for use/treatment in epilepsy. Bioallethrin Bioallethrin was used for lice and scabies infestation. Other pyrethroids are now used in place of bioallethrin. Zonisamide A sulfonamide anticonvulsant used to treat partial seizures. Loperamide A long acting antidiarrheal used to control nonspecific diarrhea and chronic diarrhea caused by inflammatory bowel disease, or gastroenteritis. Trimethadione An anticonvulsant agent indicated for the control of treatment-refractory petit mal seizures. Ethosuximide An anticonvulsant used to treat petit mal seizures. Methsuximide A succinimide anticonvulsant that increases the seizure threshold. Primarily used for childhood absence seizures. Functions by suppressing paroxysmal spike-and-wave patterns associated with lapses of consciousness in absence seizures. Fluspirilene An antipsychotic agent used in the treatment of schizophrenia. Cyclandelate A vasodilator used for the treatment of various blood vessel diseases, such as claudication and arteriosclerosis. Trimebutine A spasmolytic agent used for the symptomatic treatment of irritable bowel syndrome (IBS) and treatment of postoperative paralytic ileus following abdominal surgery. Fish oil A source of essential fatty acids used as a source of calories in parenteral nutrition and as a dietary supplement. Nylidrin A vasodilator used to treat patients with peripheral vascular disorders, and elderly patients with symptoms associated with organic mental disorders. Agmatine Agmatine is being studied experimentally for several indications such as cardioprotection, diabetes, decreased kidney function, neuroprotection (stroke, severe CNS injuries, epilepsy, glaucoma, and neuropathic pain), and psychiatric conditions (depression, anxiety,... Aranidipine Aranidipine has been used for many years to treat angina pectoris and hypertension. Levomenthol An organic compound used to treat mild to moderate muscle and joint pain. Penfluridol Not Annotated Betaxolol A cardioselective beta blocking agent commonly used to treat hypertension and elevated intraocular pressure (when administered ophthalmically). Bisoprolol A beta-1 adrenergic blocking agent used to prevent myocardial infarction and heart failure and to treat mild to moderate hypertension. Esmolol A cardioselective beta-adrenergic blocker used for the short-term control of ventricular rate and heart rate in various types of tachycardia, including perioperative tachycardia and hypertension. Nebivolol A beta blocking agent used to treat hypertension and aid in the management of heart failure. Dexverapamil Not Annotated Emopamil Prevents renal injury after warm & cold ischemia. Lomerizine Lomerizine is a diphenylmethylpiperazine calcium channel blocker[A245378, A245383] with relatively selective central nervous system (CNS) effects. This drug is used to prophylactically treat migraines[A245368, A245373] and is also being investigated... Tetrandrine Not Annotated Dexniguldipine Not Annotated Fosinoprilat Fosinoprilat is the active phosphinic acid metabolite of prodrug fosinopril, which is activated by esterases in vivo. It binds zinc with phosphinic acid group. Xylometazoline A direct-acting alpha-adrenergic agonist used for the symptomatic treatment of nasal congestion and minor inflammation due to allergies or colds. Dexpropranolol Not Available Fasudil Fasudil has been investigated in Carotid Stenosis. Hydroquinidine A medication indicated in the maintenance of a normal sinus rhythm, as well as the treatment and prevention of abnormal rhythm. Carvedilol A non selective beta-adrenergic antagonist used to treat mild to severe chronic heart failure, hypertension, and left ventricular dysfunction following myocardial infarction in clinically stable patients. SOR-C13 SOR-C13 is under investigation in clinical trial NCT01578564 (Safety and Tolerability Study of SOR-C13 in Subjects With Advanced Cancers Commonly Known to Express the TRPV6 Channel). Nifekalant Nifekalant is under investigation in clinical trial NCT03855826 (Evaluation of the Efficacy and Safety of Nifekalant Hydrochloride (NIF) Injection). Levamlodipine A calcium channel blocker used to treat hypertension. beta-Isosparteine Not Annotated Oxymatrine Oxymatrine is under investigation in clinical trial NCT02202473 (Oxymatrine Plus Lamivudine Combination Therapy Versus Lamivudine Monotherapy for Chronic Hepatitis B Infected Subjects). Etripamil Etripamil has been used in trials studying the treatment of Paroxysmal Supraventricular Tachycardia (PSVT). ACT-709478 ACT-709478 is under investigation in clinical trial NCT03239691 (A Study to Evaluate the Effect of ACT-709478 in Photosensitive Epilepsy Patients). Vanoxerine An investigational dopamine transporter antagonist suggested to be beneficial in the treatment of cocaine addiction. Tyrosol Not Annotated Enadoline Not Annotated Z-160 Z160 has been used in trials studying the treatment of Postherpetic Neuralgia and Lumbosacral Radiculopathy. SKF-96365 free base SKF-96365 is a receptor-mediated calcium entry (RMCE) inhibitor structurally different from other calcium antagonists.
- Drugs & Drug Targets