Purine Analogues

All categories

Name

Purine Analogues

Accession Number

DBCAT002249

Description

Not Available

ATC Classification

Drugs

Drug	Drug Description
Cladribine	A purine antimetabolite used for the management of relapsing forms of Multiple Sclerosis (MS), used in patients who have not responded to or who were unable to tolerate alternative MS drugs.
Tioguanine	A purine analogue antineoplastic agent used for the induction of remission, and for remission consolidation in patients with acute nonlymphocytic anemias.
Clofarabine	A purine nucleoside used to treat relapsed or refractory acute lymphoblastic leukemia in patients 1 to 21 years old.
Mercaptopurine	An antineoplastic agent used to treat acute lymphocytic leukemia.
Fludarabine	A purine analog antimetabolite that inhibits DNA synthesis.
Nelarabine	A purine nucleoside analog and antineoplastic agent used for the treatment of with acute T-cell lymphoblastic leukemia and T-cell lymphoblastic lymphoma with inadequate clinical response to prior chemotherapeutic treatments.

Drugs & Drug Targets

Drug	Target	Type
Cladribine	Purine nucleoside phosphorylase	target
Cladribine	DNA	target
Cladribine	Deoxycytidine kinase	enzyme
Cladribine	Ribonucleoside-diphosphate reductase large subunit	target
Cladribine	Ribonucleoside-diphosphate reductase subunit M2	target
Cladribine	Ribonucleoside-diphosphate reductase subunit M2 B	target
Cladribine	DNA polymerase alpha catalytic subunit	target
Cladribine	DNA polymerase epsilon catalytic subunit A	target
Cladribine	DNA polymerase epsilon subunit 2	target
Cladribine	DNA polymerase epsilon subunit 3	target
Cladribine	DNA polymerase epsilon subunit 4	target
Cladribine	ATP-binding cassette sub-family G member 2	transporter
Cladribine	Solute carrier family 28 member 3	transporter
Tioguanine	DNA	target
Tioguanine	Multidrug resistance-associated protein 4	transporter
Tioguanine	Hypoxanthine-guanine phosphoribosyltransferase	enzyme
Clofarabine	DNA polymerase alpha catalytic subunit	target
Clofarabine	Ribonucleoside-diphosphate reductase large subunit	target
Clofarabine	Deoxycytidine kinase	enzyme
Clofarabine	DNA	target
Clofarabine	ATP-binding cassette sub-family G member 2	transporter
Mercaptopurine	Thiopurine S-methyltransferase	enzyme
Mercaptopurine	Xanthine dehydrogenase/oxidase	enzyme
Mercaptopurine	Hypoxanthine-guanine phosphoribosyltransferase	target
Mercaptopurine	Solute carrier family 22 member 8	transporter
Mercaptopurine	Multidrug resistance-associated protein 4	transporter
Mercaptopurine	Multidrug resistance-associated protein 5	transporter
Mercaptopurine	Sodium/nucleoside cotransporter 2	transporter
Mercaptopurine	Solute carrier family 28 member 3	transporter
Mercaptopurine	Equilibrative nucleoside transporter 1	transporter
Mercaptopurine	Equilibrative nucleoside transporter 2	transporter
Mercaptopurine	Aldehyde oxidase	enzyme
Mercaptopurine	Amidophosphoribosyltransferase	target
Mercaptopurine	Inosine-5'-monophosphate dehydrogenase	target
Fludarabine	DNA polymerase alpha catalytic subunit	target
Fludarabine	Ribonucleoside-diphosphate reductase large subunit	target
Fludarabine	Equilibrative nucleoside transporter 1	transporter
Fludarabine	DNA	target
Fludarabine	Deoxycytidine kinase	target
Fludarabine	Solute carrier family 28 member 3	transporter
Nelarabine	DNA	target
Nelarabine	Adenosine deaminase	enzyme
Nelarabine	Deoxycytidine kinase	enzyme
Nelarabine	Deoxyguanosine kinase, mitochondrial	enzyme
Nelarabine	DNA polymerase alpha catalytic subunit	target
Nelarabine	DNA ligase 1	target
Nelarabine	DNA primase small subunit	target
Nelarabine	Ribonucleoside-diphosphate reductase large subunit	target
Nelarabine	Equilibrative nucleoside transporter 1	carrier