Piperazine Derivatives

Piperazine Derivatives
Accession Number

Not Available

ATC Classification
DrugDrug Description
CetirizineA selective Histamine-1 antagonist drug used in allergic rhinitis and chronic urticaria.
BuclizineAn antihistamine and antiemetic drug for the treatment of allergy symptoms and prevention of nausea and vomiting.
MeclizineA histamine H1 antagonist used to treat nausea, vomiting, and dizziness associated with motion sickness.
CyclizineAn antihistamine and antiemetic drug used for the prevention and treatment of nausea, vomiting, and dizziness associated with motion sickness, and vertigo.
LevocetirizineAn H1-receptor antagonist used to treat symptoms associated with chronic allergic rhinitis and uncomplicated cases of chronic idiopathic urticaria.
ChlorcyclizineChlorcyclizine is a first generation phenylpiperazine class antihistamine used to treat urticaria, rhinitis, pruritus, and other allergy symptoms. Chlorcyclizine also has some local anesthetic, anticholinergic, and antiserotonergic properties, and can...
OxatomideAn antihistamine indicated in the treatment and prevention of allergic symptoms.
FlunarizineA selective calcium-entry blocker used as migraine prophylaxis in patients with severe and frequent episodes who have not responded adequately to more common treatments.
Drugs & Drug Targets
CetirizineHistamine H1 receptortarget
CetirizineP-glycoprotein 1transporter
BuclizineHistamine H1 receptortarget
BuclizineMuscarinic acetylcholine receptor M1target
MeclizineHistamine H1 receptortarget
MeclizineNuclear receptor subfamily 1 group I member 3target
MeclizineCytochrome P450 2D6enzyme
MeclizineSerum albumincarrier
CyclizineHistamine H1 receptortarget
CyclizineEstrogen sulfotransferasetarget
CyclizineCytochrome P450 2C9enzyme
CyclizineSerum albumincarrier
LevocetirizineHistamine H1 receptortarget
LevocetirizineSolute carrier family 22 member 11transporter
LevocetirizineCytochrome P450 3A4enzyme
LevocetirizineSerum albumincarrier
ChlorcyclizineHistamine H1 receptortarget
ChlorcyclizineSerum albumincarrier
FlunarizineHistamine H1 receptortarget
FlunarizineVoltage-dependent T-type calcium channel subunit alpha-1Gtarget
FlunarizineVoltage-dependent T-type calcium channel subunit alpha-1Htarget
FlunarizineVoltage-dependent T-type calcium channel subunit alpha-1Itarget
FlunarizineCytochrome P450 2D6enzyme
FlunarizineCytochrome P450 2C9enzyme
FlunarizineCytochrome P450 1A1enzyme
FlunarizineCytochrome P450 1A2enzyme
FlunarizineCytochrome P450 2A6enzyme
FlunarizineCytochrome P450 3A4enzyme