This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Summary

Oxatomide is an antihistamine indicated in the treatment and prevention of allergic symptoms.

Generic Name
Oxatomide
DrugBank Accession Number
DB12877
Background

Oxatomide has been used in trials studying the treatment of Muscular Dystrophy, Duchenne.

Type
Small Molecule
Groups
Approved, Investigational
Structure
Weight
Average: 426.564
Monoisotopic: 426.241961602
Chemical Formula
C27H30N4O
Synonyms
  • Oxatomida
  • Oxatomide
  • Oxatomidum
External IDs
  • KW-4354
  • McN-JR 35443
  • R 35 443
  • R 35,443

Pharmacology

Indication

Not Available

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Associated Conditions
Contraindications & Blackbox Warnings
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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
PathwayCategory
Oxatomide H1-Antihistamine ActionDrug action
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
DrugInteraction
AcrivastineThe risk or severity of QTc prolongation can be increased when Acrivastine is combined with Oxatomide.
AdenosineThe risk or severity of QTc prolongation can be increased when Adenosine is combined with Oxatomide.
AjmalineThe risk or severity of QTc prolongation can be increased when Ajmaline is combined with Oxatomide.
AlfuzosinThe risk or severity of QTc prolongation can be increased when Alfuzosin is combined with Oxatomide.
AlimemazineThe risk or severity of QTc prolongation can be increased when Alimemazine is combined with Oxatomide.
AmantadineThe risk or severity of QTc prolongation can be increased when Amantadine is combined with Oxatomide.
AmifampridineThe risk or severity of QTc prolongation can be increased when Amifampridine is combined with Oxatomide.
AmiodaroneThe risk or severity of QTc prolongation can be increased when Oxatomide is combined with Amiodarone.
AmisulprideThe risk or severity of QTc prolongation can be increased when Oxatomide is combined with Amisulpride.
AmitriptylineThe risk or severity of QTc prolongation can be increased when Amitriptyline is combined with Oxatomide.
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Food Interactions
  • Take with food.

Products

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International/Other Brands
Celtect / Tinset

Categories

ATC Codes
R06AE06 — Oxatomide
Drug Categories
Chemical TaxonomyProvided by Classyfire
Description
This compound belongs to the class of organic compounds known as diphenylmethanes. These are compounds containing a diphenylmethane moiety, which consists of a methane wherein two hydrogen atoms are replaced by two phenyl groups.
Kingdom
Organic compounds
Super Class
Benzenoids
Class
Benzene and substituted derivatives
Sub Class
Diphenylmethanes
Direct Parent
Diphenylmethanes
Alternative Parents
Benzimidazoles / N-alkylpiperazines / Aralkylamines / N-substituted imidazoles / Heteroaromatic compounds / Ureas / Trialkylamines / Azacyclic compounds / Organopnictogen compounds / Organooxygen compounds
show 2 more
Substituents
1,4-diazinane / Amine / Aralkylamine / Aromatic heteropolycyclic compound / Azacycle / Azole / Benzimidazole / Diphenylmethane / Heteroaromatic compound / Hydrocarbon derivative
show 14 more
Molecular Framework
Aromatic heteropolycyclic compounds
External Descriptors
Not Available
Affected organisms
Not Available

Chemical Identifiers

UNII
J31IL9Z2EE
CAS number
60607-34-3
InChI Key
BAINIUMDFURPJM-UHFFFAOYSA-N
InChI
InChI=1S/C27H30N4O/c32-27-28-24-14-7-8-15-25(24)31(27)17-9-16-29-18-20-30(21-19-29)26(22-10-3-1-4-11-22)23-12-5-2-6-13-23/h1-8,10-15,26H,9,16-21H2,(H,28,32)
IUPAC Name
1-{3-[4-(diphenylmethyl)piperazin-1-yl]propyl}-2,3-dihydro-1H-1,3-benzodiazol-2-one
SMILES
O=C1NC2=C(C=CC=C2)N1CCCN1CCN(CC1)C(C1=CC=CC=C1)C1=CC=CC=C1

References

General References
  1. AIFA Product Information: Tinset (oxatomide) for oral and topical use [Link]
Human Metabolome Database
HMDB0240225
KEGG Drug
D01773
PubChem Compound
4615
PubChem Substance
347829033
ChemSpider
4454
BindingDB
76863
RxNav
54236
ChEBI
31943
ChEMBL
CHEMBL13828
ZINC
ZINC000019632896
PharmGKB
PA163522137
Wikipedia
Oxatomide

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
2CompletedTreatmentDuchenne's Muscular Dystrophy (DMD)1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
FormRouteStrength
TabletOral
GelTopical5 %
Solution / dropsOral0.25 %
Solution / dropsOral25 MG/ML
SuspensionOral25 mg/ml
TabletOral30 mg
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.0393 mg/mLALOGPS
logP4.71ALOGPS
logP4.62ChemAxon
logS-4ALOGPS
pKa (Strongest Acidic)12.92ChemAxon
pKa (Strongest Basic)8.01ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count3ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area38.82 Å2ChemAxon
Rotatable Bond Count7ChemAxon
Refractivity130.94 m3·mol-1ChemAxon
Polarizability48.79 Å3ChemAxon
Number of Rings5ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSNot Available

Drug created at October 21, 2016 00:57 / Updated at June 12, 2021 10:54