Nucleoside and Nucleotide Reverse Transcriptase Inhibitors

Name
Nucleoside and Nucleotide Reverse Transcriptase Inhibitors
Accession Number
DBCAT002376
Description

Not Available

ATC Classification
Drugs
DrugDrug Description
EmtricitabineA nucleoside reverse transcriptase inhibitor used for the treatment and prophylaxis of HIV.
DidanosineA reverse transcriptase inhibitor used to treat HIV.
AbacavirAn antiviral nucleoside reverse transcriptase inhibitor used in combination with other antiretrovirals for the treatment of HIV.
LamivudineA reverse transcriptase inhibitor used to treat HIV and hepatitis B infections.
EntecavirA nucleoside analogue used in the treatment of chronic hepatitis B for patients with active viral replication, histological evidence of active disease, or persistent elevations in liver transaminases.
Adefovir dipivoxilA nucleotide analog used to treat chronic hepatitis B.
ZalcitabineA dideoxynucleoside used to treat HIV.
TelbivudineA thymidine nucleoside analog used for the treatment of chronic hepatitis B with clinical evidence of viral replication or persistent elevations in serum aminotransferases (ALT or AST).
ClevudineInvestigated for use/treatment in hepatitis (viral, B).
Tenofovir disoproxilA nucleotide analog reverse transcriptase inhibitor used in the treatment of Hepatitis B infection and used in the management of HIV-1 infection.
ZidovudineA dideoxynucleoside used in the treatment of HIV infection.
StavudineA dideoxynucleoside used in the treatment of HIV infection.
Tenofovir alafenamideA nucleoside analog reverse transcriptase inhibitor used for the treatment of chronic hepatitis B virus infection in adults with compensated liver disease.
Drugs & Drug Targets
DrugTargetType
EmtricitabineReverse transcriptase/RNaseHtarget
EmtricitabineDeoxycytidine kinaseenzyme
EmtricitabineAlbumincarrier
EmtricitabineMultidrug and toxin extrusion protein 1transporter
EmtricitabineGag-Pol polyproteintarget
DidanosineSolute carrier family 22 member 6transporter
DidanosinePurine nucleoside phosphorylasetarget
DidanosineReverse transcriptase/RNaseHtarget
DidanosineEquilibrative nucleoside transporter 1transporter
DidanosineEquilibrative nucleoside transporter 2transporter
DidanosineAlbumincarrier
DidanosineGag-Pol polyproteintarget
AbacavirAlcohol dehydrogenase 6enzyme
AbacavirUDP-glucuronosyltransferase 1A1enzyme
AbacavirReverse transcriptase/RNaseHtarget
AbacavirAdenosine kinaseenzyme
AbacavirGag-Pol polyproteintarget
LamivudineDNAtarget
LamivudineProtein Ptarget
LamivudineMultidrug resistance-associated protein 1transporter
LamivudineSolute carrier family 22 member 6transporter
LamivudineBroad substrate specificity ATP-binding cassette transporter ABCG2transporter
LamivudineReverse transcriptase/RNaseHtarget
LamivudineSolute carrier family 22 member 1transporter
LamivudineSolute carrier family 22 member 2transporter
LamivudineSolute carrier family 22 member 3transporter
LamivudineDeoxycytidine kinaseenzyme
LamivudineUMP-CMP kinaseenzyme
LamivudinePhosphoglycerate kinase 1enzyme
LamivudineNucleoside diphosphate kinase Aenzyme
LamivudineNucleoside diphosphate kinase Benzyme
LamivudineCholine-phosphate cytidylyltransferase Aenzyme
LamivudineEthanolamine-phosphate cytidylyltransferaseenzyme
LamivudineATP-dependent translocase ABCB1transporter
LamivudineATP-binding cassette sub-family C member 4transporter
LamivudineATP-binding cassette sub-family C member 3transporter
LamivudineATP-binding cassette sub-family C member 2transporter
Lamivudine5'(3')-deoxyribonucleotidase, cytosolic typeenzyme
LamivudineAlbumincarrier
LamivudineGag-Pol polyproteintarget
EntecavirDNAtarget
Adefovir dipivoxilProtein Ptarget
Adefovir dipivoxilSolute carrier family 22 member 6transporter
Adefovir dipivoxilATP-binding cassette sub-family C member 4transporter
Adefovir dipivoxilATP-binding cassette sub-family C member 5transporter
Adefovir dipivoxilSolute carrier family 22 member 3transporter
Adefovir dipivoxilAdenylate kinase 2, mitochondrialenzyme
Adefovir dipivoxilAdenylate kinase 4, mitochondrialenzyme
Adefovir dipivoxilNucleoside diphosphate kinase Aenzyme
Adefovir dipivoxilNucleoside diphosphate kinase Benzyme
ZalcitabineDeoxycytidine kinaseenzyme
ZalcitabineSolute carrier family 22 member 6transporter
ZalcitabineSolute carrier family 22 member 7transporter
ZalcitabineReverse transcriptase/RNaseHtarget
ZalcitabineEquilibrative nucleoside transporter 1transporter
ZalcitabineEquilibrative nucleoside transporter 2transporter
ZalcitabineAlbumincarrier
ZalcitabineGag-Pol polyproteintarget
TelbivudineProtein Ptarget
TelbivudineDNAtarget
Tenofovir disoproxilReverse transcriptase/RNaseHtarget
Tenofovir disoproxilSolute carrier family 22 member 6transporter
Tenofovir disoproxilOrganic anion transporter 3transporter
Tenofovir disoproxilATP-binding cassette sub-family C member 10transporter
Tenofovir disoproxilATP-binding cassette sub-family C member 4transporter
Tenofovir disoproxilATP-binding cassette sub-family C member 2transporter
Tenofovir disoproxilAdenylate kinase 2, mitochondrialenzyme
Tenofovir disoproxilAdenylate kinase 4, mitochondrialenzyme
Tenofovir disoproxilATP-dependent translocase ABCB1transporter
Tenofovir disoproxilNucleoside diphosphokinaseenzyme
Tenofovir disoproxilCreatine Kinasesenzyme
Tenofovir disoproxilProtein Ptarget
Tenofovir disoproxilGag-Pol polyproteintarget
ZidovudineAlbumincarrier
ZidovudineCytochrome P450 2A6enzyme
ZidovudineCytochrome P450 2C9enzyme
ZidovudineCytochrome P450 3A4enzyme
ZidovudineReverse transcriptase/RNaseHtarget
ZidovudineSolute carrier family 22 member 2transporter
ZidovudineSolute carrier family 22 member 6transporter
ZidovudineSolute carrier family 22 member 7transporter
ZidovudineOrganic anion transporter 3transporter
ZidovudineSolute carrier family 22 member 11transporter
ZidovudineSodium/nucleoside cotransporter 1transporter
ZidovudineEquilibrative nucleoside transporter 2transporter
ZidovudineATP-dependent translocase ABCB1transporter
ZidovudineATP-binding cassette sub-family C member 4transporter
ZidovudineATP-binding cassette sub-family C member 5transporter
ZidovudineBroad substrate specificity ATP-binding cassette transporter ABCG2transporter
ZidovudineTelomerase reverse transcriptasetarget
ZidovudineThymidine kinase, cytosolicenzyme
ZidovudineUDP-glucuronosyltransferase 2B7enzyme
ZidovudineUDP-glucuronosyltransferase 1A1enzyme
ZidovudineGag-Pol polyproteintarget
ZidovudineReceptor-type tyrosine-protein kinase FLT3target
StavudineSolute carrier family 22 member 6transporter
StavudineReverse transcriptase/RNaseHtarget
StavudineSodium/nucleoside cotransporter 1transporter
StavudineAlbumincarrier
StavudineGag-Pol polyproteintarget
Tenofovir alafenamideReverse transcriptase/RNaseHtarget
Tenofovir alafenamideATP-dependent translocase ABCB1transporter
Tenofovir alafenamideATP-binding cassette sub-family C member 4transporter
Tenofovir alafenamideSolute carrier family 22 member 6transporter
Tenofovir alafenamideOrganic anion transporter 3transporter
Tenofovir alafenamideLysosomal protective proteinenzyme
Tenofovir alafenamideLiver carboxylesterase 1enzyme
Tenofovir alafenamideBroad substrate specificity ATP-binding cassette transporter ABCG2transporter
Tenofovir alafenamideSolute carrier organic anion transporter family member 1B1transporter
Tenofovir alafenamideSolute carrier organic anion transporter family member 1B3transporter
Tenofovir alafenamideReverse transcriptasetarget
Tenofovir alafenamideDNA polymerasetarget
Tenofovir alafenamideAlbumincarrier
Tenofovir alafenamideCytochrome P450 3A4enzyme
Tenofovir alafenamideAdenylate kinase isoenzyme 1enzyme
Tenofovir alafenamideAdenylate kinase 2, mitochondrialenzyme
Tenofovir alafenamideNucleoside diphosphate kinase Aenzyme
Tenofovir alafenamideNucleoside diphosphate kinase Benzyme
Tenofovir alafenamideGag-Pol polyproteintarget