Bile and Liver Therapy

Name
Bile and Liver Therapy
Accession Number
DBCAT002536
Description

Not Available

ATC Classification
Drugs
DrugDrug Description
Ursodeoxycholic acidA bile acid used for the treatment of primary biliary cirrhosis (PBC), dissolution of radiolucent gallstones in patients with a functioning gallbladder, and treatment of hepatobiliary disorders associated with cystic fibrosis in pediatric patients.
Cholic AcidA bile acid used for the treatment of bile acid synthesis disorders due to single enzyme defects and as an adjunctive treatment of peroxisomal disorders with disrupted liver function.
Obeticholic acidA bile acid analog and farnesoid X receptor agonist used to treat primary biliary cholangitis in adult patients with inadequate clinical response or intolerance to UDCA.
Chenodeoxycholic acidA bile acid used for the treatment of primary biliary cirrhosis.
HymecromoneA coumarin derivative that lacks anticoagulant properties but possesses choleretic and biliary antispasmodic activity.
N-methylnicotinamideN-methylnicotinamide is an experimental drug with no approved indication.
PiprozolinNot Annotated
Arginine glutamateTwo amino acids indicated in the treatment of hyperammonemia and in combination for total parenteral nutrition.
CitioloneNot Annotated
CyclobutyrolNot Annotated
Tidiacic arginineNot Annotated
Glycyrrhizic acidGlycyrrhizic acid is widely applied in foods as a natural sweetener. As a therapeutic agent, is has been used in a vast variety of formulations as it is reported to...
EpomediolNot Annotated
OrnithineAn amino acid commonly found as a component in total parenteral nutrition.
SilibininA flavonolignan with hepatoprotective effects used to treat toxic liver damage and as an adjunct in the management of chronic conditions such as cirrhosis and hepatitis.
Drugs & Drug Targets
DrugTargetType
Ursodeoxycholic acidAldo-keto reductase family 1 member C2target
Ursodeoxycholic acidBile salt export pumptransporter
Ursodeoxycholic acidSolute carrier organic anion transporter family member 1A2transporter
Ursodeoxycholic acidCanalicular multispecific organic anion transporter 1transporter
Ursodeoxycholic acidMultidrug resistance-associated protein 4transporter
Ursodeoxycholic acidIleal sodium/bile acid cotransportertransporter
Ursodeoxycholic acidSodium/bile acid cotransportertransporter
Ursodeoxycholic acidBile acid receptortarget
Ursodeoxycholic acidCytochrome P450 3A Subfamilyenzyme
Cholic AcidFerrochelatase, mitochondrialtarget
Cholic AcidBile salt export pumptransporter
Cholic AcidP-glycoprotein 1transporter
Cholic AcidMultidrug resistance-associated protein 1transporter
Cholic AcidSolute carrier organic anion transporter family member 1A2transporter
Cholic AcidIleal sodium/bile acid cotransportertransporter
Cholic AcidCanalicular multispecific organic anion transporter 1transporter
Cholic AcidSolute carrier organic anion transporter family member 1B1transporter
Cholic AcidCanalicular multispecific organic anion transporter 2transporter
Cholic AcidMultidrug resistance-associated protein 4transporter
Cholic AcidSodium/bile acid cotransportertransporter
Cholic AcidSolute carrier family 22 member 8transporter
Cholic AcidSolute carrier family 22 member 7transporter
Cholic AcidSolute carrier organic anion transporter family member 1B3transporter
Cholic AcidAlcohol dehydrogenase 1Ctarget
Cholic AcidEstrogen-related receptor gammatarget
Cholic AcidGastrotropintarget
Cholic AcidCytochrome c oxidase subunit 4 isoform 1, mitochondrialtarget
Cholic AcidCytochrome c oxidase subunit 1target
Cholic AcidCytochrome c oxidase subunit 2target
Cholic AcidCytochrome c oxidase subunit 3target
Cholic AcidCytochrome c oxidase subunit 5A, mitochondrialtarget
Cholic AcidCytochrome c oxidase subunit 5B, mitochondrialtarget
Cholic AcidCytochrome c oxidase subunit 6Ctarget
Cholic AcidCytochrome c oxidase subunit 7B, mitochondrialtarget
Cholic AcidCytochrome c oxidase subunit 7C, mitochondrialtarget
Cholic AcidCytochrome c oxidase subunit 8A, mitochondrialtarget
Cholic AcidCytochrome c oxidase subunit 6A2, mitochondrialtarget
Cholic AcidCytochrome c oxidase subunit 6B1target
Cholic AcidCytochrome c oxidase subunit 7A1, mitochondrialtarget
Cholic AcidPhospholipase A2target
Cholic AcidLiver carboxylesterase 1target
Cholic AcidFatty acid-binding protein, livercarrier
Cholic AcidFerrochelatasetarget
Cholic AcidCholoylglycine hydrolasetarget
Cholic AcidBile acid receptortarget
Cholic AcidG-protein coupled bile acid receptor 1target
Obeticholic acidBile acid receptortarget
Obeticholic acidCytochrome P450 1A2enzyme
Obeticholic acidBile salt export pumptransporter
Chenodeoxycholic acidBile acid receptortarget
Chenodeoxycholic acidSterol 26-hydroxylase, mitochondrialenzyme
Chenodeoxycholic acidCytochrome P450 3A4enzyme
Chenodeoxycholic acidUDP-glucuronosyltransferase 2B7enzyme
Chenodeoxycholic acidNuclear receptor subfamily 1 group I member 2target
Chenodeoxycholic acidG-protein coupled bile acid receptor 1target
Chenodeoxycholic acidAldo-keto reductase family 1 member C2target
HymecromoneArylsulfate sulfotransferasetarget
N-methylnicotinamideSolute carrier family 22 member 2transporter
N-methylnicotinamideMultidrug and toxin extrusion protein 1transporter
N-methylnicotinamideMultidrug and toxin extrusion protein 2transporter
N-methylnicotinamideAldehyde oxidaseenzyme
Glycyrrhizic acidCorticosteroid 11-beta-dehydrogenase isozyme 1target
Glycyrrhizic acidAldo-keto reductase family 1 member C4carrier
Glycyrrhizic acidAldo-keto reductase family 1 member C3carrier
Glycyrrhizic acidAldo-keto reductase family 1 member C2carrier
Glycyrrhizic acidTumor necrosis factortarget
Glycyrrhizic acidCaspase-3target
Glycyrrhizic acidNuclear factor NF-kappa-Btarget
Glycyrrhizic acidLipoprotein lipasetarget
Glycyrrhizic acidSerum albumincarrier
Glycyrrhizic acidBile salt export pumptransporter
OrnithineOrnithine aminotransferase, mitochondrialtarget
OrnithineOrnithine carbamoyltransferase, mitochondrialtarget
OrnithineArginase-1target
OrnithineOrnithine decarboxylase antizyme 1target
OrnithineLow affinity cationic amino acid transporter 2target
OrnithineMitochondrial ornithine transporter 2target
OrnithineHigh affinity cationic amino acid transporter 1target
OrnithineArginase-2, mitochondrialtarget
OrnithineMitochondrial ornithine transporter 1target
OrnithineGlycine amidinotransferase, mitochondrialtarget
SilibininSolute carrier family 22 member 6transporter
SilibininUDP-glucuronosyltransferase 1-1enzyme
SilibininSolute carrier organic anion transporter family member 1B1transporter
SilibininSolute carrier organic anion transporter family member 1B3transporter
SilibininSolute carrier organic anion transporter family member 2B1transporter