Cytochrome P-450 CYP3A5 Inhibitors (strong)

Name
Cytochrome P-450 CYP3A5 Inhibitors (strong)
Accession Number
DBCAT003808
Description

Not Available

Drugs
DrugDrug Description
BoceprevirA hepatitis C virus NS3/4A protease inhibitor used in combination with other medications to treat chronic hepatitis C genotype 1 infection. Boceprevir is not indicated as monotherapy.
KetoconazoleA broad spectrum antifungal used to treat seborrheic dermatitis and fungal skin infections.
TroleandomycinFor the treatment of bacterial infection.
NelfinavirA viral protease inhibitor used in the treatment of HIV infection.
ClarithromycinA macrolide antibiotic used for the treatment of a wide variety of bacterial infections such as acute otitis, pharyngitis, tonsillitis, respiratory tract infections, uncomplicated skin infections, and helicobacter pylori infection.
ItraconazoleA triazole antifungal agent used to treat various fungal infections, such as blastomycosis and onychomycosis.
RitonavirAn HIV protease inhibitor used in combination with other antivirals in the treatment of HIV infection.
SaquinavirAn HIV protease inhibitor used in combination with other antiretroviral agents for the treatment of HIV-1 with advanced immunodeficiency.
LonafarnibA potent farnesyl transferase inhibitor used to reduce mortality associated with Hutchinson-Gilford progeria syndrome (HGPS) and other progeroid laminopathies.
VoriconazoleA triazole compound used to treat fungal infections.
Drugs & Drug Targets
DrugTargetType
BoceprevirCytochrome P450 3A4enzyme
BoceprevirCytochrome P450 3A5enzyme
BoceprevirATP-dependent translocase ABCB1transporter
BoceprevirGenome polyproteintarget
BoceprevirGenome polyproteintarget
KetoconazoleCytochrome P450 3A4enzyme
KetoconazoleCytochrome P450 2C9enzyme
KetoconazoleCytochrome P450 2C19enzyme
KetoconazoleCytochrome P450 3A5enzyme
KetoconazoleCytochrome P450 1A2enzyme
KetoconazoleCytochrome P450 2C8enzyme
KetoconazoleCytochrome P450 1A1enzyme
KetoconazoleCytochrome P450 2D6enzyme
KetoconazoleBile salt export pumptransporter
KetoconazoleATP-dependent translocase ABCB1transporter
KetoconazoleCytochrome P450 11B1, mitochondrialenzyme
KetoconazoleCytochrome P450 1B1enzyme
KetoconazoleCytochrome P450 2A6enzyme
KetoconazoleCytochrome P450 2B6enzyme
KetoconazoleLanosterol 14-alpha demethylasetarget
KetoconazoleAndrogen receptortarget
KetoconazoleSteroid 17-alpha-hydroxylase/17,20 lyasetarget
KetoconazoleSteroid 21-hydroxylasetarget
KetoconazoleVoltage-gated inwardly rectifying potassium channel KCNH2target
KetoconazoleNuclear receptor subfamily 1 group I member 2target
KetoconazoleNuclear receptor subfamily 1 group I member 3target
KetoconazoleUDP-glucuronosyltransferase 1A1enzyme
KetoconazoleUDP-glucuronosyltransferase 2B7enzyme
KetoconazoleSolute carrier organic anion transporter family member 1B1transporter
KetoconazoleCytochrome P450 4F12enzyme
KetoconazoleCytochrome P450 4F2enzyme
KetoconazoleAlbumincarrier
KetoconazoleSex hormone-binding globulincarrier
KetoconazoleAromataseenzyme
KetoconazoleUDP-glucuronosyltransferase 1A7enzyme
KetoconazoleLanosterol 14-alpha demethylasetarget
TroleandomycinCytochrome P450 3A5enzyme
TroleandomycinCytochrome P450 3A43enzyme
Troleandomycin50S ribosomal protein L4target
Troleandomycin50S ribosomal protein L32target
TroleandomycinATP-dependent translocase ABCB1transporter
TroleandomycinCytochrome P450 2C8enzyme
TroleandomycinCytochrome P450 3A4enzyme
TroleandomycinNuclear receptor subfamily 1 group I member 2target
TroleandomycinCytochrome P450 3A7enzyme
NelfinavirHIV-1 proteasetarget
NelfinavirCytochrome P450 2C19enzyme
NelfinavirCytochrome P450 3A4enzyme
NelfinavirCytochrome P450 2B6enzyme
NelfinavirCytochrome P450 3A5enzyme
NelfinavirCytochrome P450 3A7enzyme
NelfinavirATP-dependent translocase ABCB1transporter
NelfinavirSolute carrier family 22 member 1transporter
NelfinavirSolute carrier organic anion transporter family member 1A2transporter
NelfinavirBroad substrate specificity ATP-binding cassette transporter ABCG2transporter
NelfinavirSolute carrier organic anion transporter family member 1B1transporter
NelfinavirCytochrome P450 2D6enzyme
NelfinavirAlbumincarrier
NelfinavirUDP-glucuronosyltransferase 1A1enzyme
NelfinavirSolute carrier organic anion transporter family member 1B3transporter
NelfinavirSolute carrier organic anion transporter family member 2B1transporter
NelfinavirBile salt export pumptransporter
NelfinavirCytochrome P450 2C9enzyme
NelfinavirAlpha-1-acid glycoprotein 1carrier
Clarithromycin50S ribosomal protein L10target
ClarithromycinCytochrome P450 3A4enzyme
ClarithromycinCytochrome P450 3A5enzyme
ClarithromycinATP-dependent translocase ABCB1transporter
ClarithromycinSolute carrier family 22 member 7transporter
ClarithromycinVoltage-gated inwardly rectifying potassium channel KCNH2target
ClarithromycinSolute carrier organic anion transporter family member 1B1target
ClarithromycinSolute carrier organic anion transporter family member 1B3target
ClarithromycinBile salt export pumptransporter
ClarithromycinSolute carrier organic anion transporter family member 1B1transporter
ClarithromycinSolute carrier organic anion transporter family member 1B3transporter
ItraconazoleCytochrome P450 3A4enzyme
ItraconazoleCytochrome P450 3A5enzyme
ItraconazoleCytochrome P450 3A7enzyme
ItraconazoleCytochrome P450 2B6enzyme
ItraconazoleATP-dependent translocase ABCB1transporter
ItraconazoleCytochrome P450 1A1enzyme
ItraconazoleCytochrome P450 2E1enzyme
ItraconazoleSolute carrier organic anion transporter family member 2B1transporter
ItraconazoleCytochrome P450 3A Subfamilyenzyme
ItraconazoleBroad substrate specificity ATP-binding cassette transporter ABCG2transporter
ItraconazoleAlbumincarrier
ItraconazoleLanosterol 14-alpha demethylasetarget
ItraconazoleLanosterol 14-alpha demethylasetarget
RitonavirPol polyproteintarget
RitonavirCytochrome P450 2D6enzyme
RitonavirCytochrome P450 2C9enzyme
RitonavirCytochrome P450 2C19enzyme
RitonavirCytochrome P450 2B6enzyme
RitonavirCytochrome P450 2C8enzyme
RitonavirATP-dependent translocase ABCB1transporter
RitonavirMultidrug resistance-associated protein 1transporter
RitonavirATP-binding cassette sub-family C member 2transporter
RitonavirSolute carrier organic anion transporter family member 1A2transporter
RitonavirBroad substrate specificity ATP-binding cassette transporter ABCG2transporter
RitonavirSolute carrier organic anion transporter family member 1B1transporter
RitonavirCytochrome P450 1A2enzyme
RitonavirNuclear receptor subfamily 1 group I member 2target
RitonavirAlbumincarrier
RitonavirCytochrome P450 3A4enzyme
RitonavirCytochrome P450 3A5enzyme
RitonavirCytochrome P450 3A7enzyme
RitonavirUDP-glucuronosyltransferases (UGTs)enzyme
RitonavirSolute carrier organic anion transporter family member 2B1transporter
RitonavirBile salt export pumptransporter
RitonavirAlpha-1-acid glycoprotein 1carrier
RitonavirSolute carrier organic anion transporter family member 1B3transporter
RitonavirGag-Pol polyproteintarget
SaquinavirPol polyproteintarget
SaquinavirCytochrome P450 3A4enzyme
SaquinavirCytochrome P450 3A5enzyme
SaquinavirAlpha-1-acid glycoprotein 1carrier
SaquinavirAlbumincarrier
SaquinavirCytochrome P450 3A7enzyme
SaquinavirATP-dependent translocase ABCB1transporter
SaquinavirSolute carrier family 22 member 1transporter
SaquinavirSolute carrier organic anion transporter family member 1A2transporter
SaquinavirBroad substrate specificity ATP-binding cassette transporter ABCG2transporter
SaquinavirSolute carrier organic anion transporter family member 1B1transporter
SaquinavirMultidrug resistance-associated protein 1transporter
SaquinavirATP-binding cassette sub-family C member 2transporter
SaquinavirCytochrome P450 2C8enzyme
SaquinavirCytochrome P450 2D6enzyme
SaquinavirSolute carrier organic anion transporter family member 2B1transporter
SaquinavirBile salt export pumptransporter
SaquinavirGag-Pol polyproteintarget
LonafarnibProtein farnesyltransferase/geranylgeranyltransferase type-1 subunit alphatarget
LonafarnibATP-dependent translocase ABCB1transporter
LonafarnibProtein farnesyltransferase subunit betatarget
LonafarnibCytochrome P450 3A Subfamilyenzyme
LonafarnibCytochrome P450 2C8enzyme
LonafarnibCytochrome P450 2C19enzyme
LonafarnibCytochrome P450 1A2enzyme
LonafarnibCytochrome P450 2A6enzyme
LonafarnibCytochrome P450 2C9enzyme
LonafarnibCytochrome P450 2E1enzyme
LonafarnibSolute carrier organic anion transporter family member 1B1transporter
LonafarnibSolute carrier organic anion transporter family member 1B3transporter
LonafarnibBroad substrate specificity ATP-binding cassette transporter ABCG2transporter
LonafarnibCytochrome P450 3A4enzyme
LonafarnibCytochrome P450 3A5enzyme
LonafarnibATP-binding cassette sub-family C member 2transporter
VoriconazoleCytochrome P450 2C19enzyme
VoriconazoleCytochrome P450 3A4enzyme
VoriconazoleCytochrome P450 2C9enzyme
VoriconazoleFlavin-containing monooxygenase 1enzyme
VoriconazoleFlavin-containing monooxygenase 3enzyme
VoriconazoleCytochrome P450 3A5enzyme
VoriconazoleCytochrome P450 3A7enzyme
VoriconazoleProstaglandin G/H synthase 1enzyme
VoriconazoleLanosterol 14-alpha demethylasetarget
VoriconazoleCytochrome P450 2B6enzyme