Troleandomycin

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DB13179ApprovedSmall molecule

A macrolide antibiotic that is similar to erythromycin.

Mechanism: As a macrolide, troleandomycin binds to the 50S subunit of the bacterial ribosome. This binding inhibits translocation of tRNA along the A, P, and E sites of the ribosome. With tRNA unable to move from site to site, amino acids cannot be deposited onto the polypeptide chain leading to failure of protein synthesis. Bacterial cell growth and duplication is inhibited without the ability to generate the necessary proteins.
Curator reviewed · 1 reference
Primary indication: For the treatment of bacterial infection.Curator reviewed
Formula / weight: C₄₁H₆₇NO₁₅ · 813.9684 g/mol (avg)
Also known as: Oleandocetine · Oleandomycin triacetate · Oleandomycin triacetyl ester · Triacetyloleandomycin · Tribiocillina
Code names: NSC-108166

Resolves to

Compound

UNIIC4DZ64560DCAS2751-09-9ChEMBLCHEMBL564085ChEBI45735PubChem202225KEGGD01322

Clinical / RWD

RxNorm10864ATCJ01FA08PharmGKBPA127840611

Structure

InChIKeyLQCLVBQBTUVCEQ-QTFUVMRISA-NSMILES

CO[C@H]1C[C@H](O[C@H]2[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@@H]([C@H]3OC(C)=O)N(C)C)[C@@H](C)C[C@@]3(CO3)C(=O)[C@H](C)[C@@H](OC(C)=O)[C@@H](C)[C@@H](C)OC(=O)[C@@H]2C)O[C@@H](C)[C@@H]1OC(C)=O

Targets

P49228rpmFP60723rplDO75469NR1I2

Transporters

P08183ABCB1

What you can answer from here — as of February 21, 2021

3Protein targetsEach mapped to UniProt, with action and pharmacological action

Listed above

1TransporterSubstrate / inhibitor direction, not just membership

Listed above

938Drug interactionsStructured to mechanism, not free text

1ATC codeIncluding every combination product, plus 21 drug categories

17+ReferencesStructured and connected to the statements they support

Which drugs share a target with Troleandomycin, and which of those have an active Phase 3 trial?

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