Cytochrome P-450 CYP2B6 Substrates with a Narrow Therapeutic Index

Name
Cytochrome P-450 CYP2B6 Substrates with a Narrow Therapeutic Index
Accession Number
DBCAT004030
Description

Not Available

Drugs
DrugDrug Description
DosulepinA tricyclic antidepressant commonly used only in patients for whom alternative therapies are ineffective due to its toxicity potential.
ZanubrutinibA kinase inhibitor used to treat mantle cell lymphoma, a type of B-cell non-Hodgkin lymphoma, in adults who previously received therapy.
EnasidenibAn isocitrate dehydrogenase-2 inhibitor used to treat relapsed or refractory acute myeloid leukemia with an isocitrate dehydrogenase-2 mutation.
IxazomibA monoclonal antibody used with other medications to treat multiple myeloma in patients who have received one other therapy already.
TamoxifenA selective estrogen receptor modulator used to treat estrogen receptor positive breast cancer, reduce the risk of invasive breast cancer following surgery, or reduce the risk of breast cancer in high risk women.
CyclophosphamideA nitrogen mustard used to treat lymphomas, myelomas, leukemia, mycosis fungoides, neuroblastoma, ovarian adenocarcinoma, retinoblastoma, and breast carcinoma.
IfosfamideAn alkylating and immunosuppressive agent used in chemotherapy for the treatment of cancers, including testicular cancer, ovarian cancer, cervical cancer, osteocarcinoma, bladder cancer, small cell lung cancer, and non-Hodgkin's lymphoma.
PhenytoinAn anticonvulsant drug used in the prophylaxis and control of various types of seizures.
CarbamazepineAn anticonvulsant used to treat various types of seizures and pain resulting from trigeminal neuralgia.
Valproic acidAn anticonvulsant used to control complex partial seizures and both simple and complex absence seizures.
IrinotecanAn antineoplastic enzyme inhibitor used to treat metastatic carcinoma of the colon or rectum.
AmitriptylineA tricyclic antidepressant indicated in the treatment of depressive illness, either endogenous or psychotic, and to relieve depression associated anxiety.
ImipramineA tricyclic antidepressant indicated for the treatment of depression and to reduce childhood enuresis.
RomidepsinA histone deacetylase (HDAC) inhibitor used to treat cutaneous and peripheral T-cell lymphoma.
Drugs & Drug Targets
DrugTargetType
Dosulepin5-hydroxytryptamine receptor 1Atarget
Dosulepin5-hydroxytryptamine receptor 2Atarget
DosulepinCytochrome P450 2D6enzyme
DosulepinCytochrome P450 1A2enzyme
DosulepinCytochrome P450 2C19enzyme
DosulepinCytochrome P450 2C9enzyme
DosulepinHistamine H1 receptortarget
DosulepinMuscarinic acetylcholine receptor M1target
DosulepinMuscarinic acetylcholine receptor M2target
DosulepinMuscarinic acetylcholine receptor M3target
DosulepinMuscarinic acetylcholine receptor M4target
DosulepinMuscarinic acetylcholine receptor M5target
DosulepinSodium-dependent noradrenaline transportertarget
DosulepinSodium-dependent serotonin transportertarget
DosulepinAlpha-1 adrenergic receptorstarget
DosulepinAlpha-2 adrenergic receptorstarget
ZanubrutinibCytochrome P450 3A4enzyme
ZanubrutinibP-glycoprotein 1transporter
ZanubrutinibCytochrome P450 2B6enzyme
ZanubrutinibTyrosine-protein kinase BTKtarget
ZanubrutinibEpidermal growth factor receptortarget
ZanubrutinibReceptor tyrosine-protein kinase erbB-2target
ZanubrutinibReceptor tyrosine-protein kinase erbB-4target
ZanubrutinibTyrosine-protein kinase ITK/TSKtarget
ZanubrutinibCytoplasmic tyrosine-protein kinase BMXtarget
ZanubrutinibTyrosine-protein kinase JAK2target
ZanubrutinibTyrosine-protein kinase Tectarget
ZanubrutinibTyrosine-protein kinase Blktarget
ZanubrutinibTyrosine-protein kinase JAK3target
ZanubrutinibProtein-tyrosine kinase 6target
ZanubrutinibTyrosine-protein kinase Fgrtarget
ZanubrutinibTyrosine-protein kinase FRKtarget
ZanubrutinibTyrosine-protein kinase Lcktarget
ZanubrutinibTyrosine-protein kinase TXKtarget
ZanubrutinibCytochrome P450 3A Subfamilyenzyme
EnasidenibCytochrome P450 1A2enzyme
EnasidenibCytochrome P450 2B6enzyme
EnasidenibIsocitrate dehydrogenase [NADP], mitochondrialtarget
EnasidenibCytochrome P450 2C8enzyme
EnasidenibCytochrome P450 2C9enzyme
EnasidenibCytochrome P450 2C19enzyme
EnasidenibCytochrome P450 2D6enzyme
EnasidenibCytochrome P450 3A4enzyme
EnasidenibUDP-glucuronosyltransferase 1-1enzyme
EnasidenibUDP-glucuronosyltransferase 1-3enzyme
EnasidenibUDP-glucuronosyltransferase 1-4enzyme
EnasidenibUDP-glucuronosyltransferase 1-9enzyme
EnasidenibUDP-glucuronosyltransferase 2B7enzyme
EnasidenibUDP-glucuronosyltransferase 2B15enzyme
EnasidenibP-glycoprotein 1transporter
EnasidenibATP-binding cassette sub-family G member 2transporter
EnasidenibSolute carrier family 22 member 6transporter
EnasidenibSolute carrier organic anion transporter family member 1B1transporter
EnasidenibSolute carrier family 22 member 2transporter
EnasidenibSolute carrier organic anion transporter family member 1B3transporter
EnasidenibSolute carrier family 22 member 8transporter
IxazomibCytochrome P450 3A4enzyme
IxazomibCytochrome P450 1A2enzyme
IxazomibCytochrome P450 2B6enzyme
IxazomibCytochrome P450 2C8enzyme
IxazomibCytochrome P450 2D6enzyme
IxazomibCytochrome P450 2C19enzyme
IxazomibCytochrome P450 2C9enzyme
TamoxifenEstrogen receptor alphatarget
TamoxifenEstrogen receptor betatarget
TamoxifenCytochrome P450 2C9enzyme
TamoxifenCytochrome P450 3A4enzyme
TamoxifenCytochrome P450 2D6enzyme
TamoxifenCytochrome P450 2C8enzyme
TamoxifenCytochrome P450 2B6enzyme
TamoxifenLiver carboxylesterase 1enzyme
TamoxifenCytochrome P450 3A5enzyme
TamoxifenCytochrome P450 1A1enzyme
TamoxifenCytochrome P450 1B1enzyme
TamoxifenCytochrome P450 2C19enzyme
TamoxifenDimethylaniline monooxygenase [N-oxide-forming] 1enzyme
TamoxifenDimethylaniline monooxygenase [N-oxide-forming] 3enzyme
TamoxifenCytochrome P450 3A7enzyme
TamoxifenP-glycoprotein 1transporter
TamoxifenATP-binding cassette sub-family G member 2transporter
TamoxifenCytochrome P450 19A1enzyme
TamoxifenCytochrome P450 2A6enzyme
TamoxifenCytochrome P450 2E1enzyme
TamoxifenUDP-glucuronosyltransferase 1-10enzyme
TamoxifenSulfotransferase 1A1enzyme
TamoxifenCanalicular multispecific organic anion transporter 1transporter
Tamoxifen3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerasetarget
TamoxifenProtein kinase Ctarget
TamoxifenAndrogen receptortarget
TamoxifenPotassium voltage-gated channel subfamily H member 2target
TamoxifenNuclear receptor subfamily 1 group I member 2target
TamoxifenEstrogen-related receptor gammatarget
TamoxifenSex hormone-binding globulintarget
TamoxifenBile salt export pumptransporter
TamoxifenThyroxine-binding globulincarrier
TamoxifenBile salt sulfotransferaseenzyme
TamoxifenCytochrome P450 1A2enzyme
TamoxifenUDP-glucuronosyltransferase 2B7enzyme
TamoxifenUDP-glucuronosyltransferase 2B17enzyme
TamoxifenEstrogen sulfotransferaseenzyme
TamoxifenATP-binding cassette sub-family A member 1transporter
TamoxifenMitogen-activated protein kinase 8target
TamoxifenSerum albumincarrier
CyclophosphamideDNAtarget
CyclophosphamideCytochrome P450 2B6enzyme
CyclophosphamideCytochrome P450 2C9enzyme
CyclophosphamideCytochrome P450 3A4enzyme
CyclophosphamideCytochrome P450 2C19enzyme
CyclophosphamideCytochrome P450 2A6enzyme
CyclophosphamideCytochrome P450 2C18enzyme
CyclophosphamideCytochrome P450 2C8enzyme
CyclophosphamideCytochrome P450 3A5enzyme
CyclophosphamideNuclear receptor subfamily 1 group I member 2target
IfosfamideCytochrome P450 2B6enzyme
IfosfamideDNAtarget
IfosfamideCytochrome P450 3A4enzyme
IfosfamideCytochrome P450 3A5enzyme
IfosfamideCytochrome P450 2C9enzyme
IfosfamideCytochrome P450 2C8enzyme
IfosfamideCytochrome P450 2A6enzyme
IfosfamideCytochrome P450 2C19enzyme
IfosfamideCytochrome P450 2C18enzyme
IfosfamideProstaglandin G/H synthase 1enzyme
IfosfamideNuclear receptor subfamily 1 group I member 2target
PhenytoinSodium channel protein type 5 subunit alphatarget
PhenytoinSodium channel protein type 1 subunit alphatarget
PhenytoinCytochrome P450 2C8enzyme
PhenytoinCytochrome P450 2C19enzyme
PhenytoinCytochrome P450 2C9enzyme
PhenytoinCytochrome P450 2B6enzyme
PhenytoinCytochrome P450 3A5enzyme
PhenytoinSerum albumincarrier
PhenytoinCytochrome P450 3A4enzyme
PhenytoinSolute carrier organic anion transporter family member 1C1transporter
PhenytoinP-glycoprotein 1transporter
PhenytoinCanalicular multispecific organic anion transporter 1transporter
PhenytoinCytochrome P450 11B1, mitochondrialenzyme
PhenytoinCytochrome P450 3A7enzyme
PhenytoinNuclear receptor subfamily 1 group I member 2target
PhenytoinSodium channel subunit beta-1target
PhenytoinSodium channel protein type 3 subunit alphatarget
PhenytoinUDP-glucuronosyltransferase 1-1enzyme
PhenytoinUDP-glucuronosyltransferase 1-6enzyme
PhenytoinUDP-glucuronosyltransferase 1-9enzyme
PhenytoinThyroxine-binding globulincarrier
PhenytoinPotassium voltage-gated channel subfamily H member 2target
PhenytoinVoltage-dependent L-type calcium channeltarget
PhenytoinSodium channel protein type 2 subunit alphatarget
PhenytoinSodium channel protein type 8 subunit alphatarget
PhenytoinGABA(A) Receptortarget
PhenytoinCytochrome P450 1A2enzyme
PhenytoinCytochrome P450 2A6enzyme
PhenytoinCytochrome P450 2D6enzyme
PhenytoinCytochrome P450 2E1enzyme
PhenytoinEpoxide hydrolase 1enzyme
PhenytoinUDP-glucuronosyltransferase 1-4enzyme
PhenytoinCatechol O-methyltransferaseenzyme
PhenytoinNAD(P)H dehydrogenase [quinone] 1enzyme
PhenytoinCytochrome P450 2C18enzyme
CarbamazepineVoltage-gated sodium channel alpha subunittarget
CarbamazepineCytochrome P450 2C8enzyme
CarbamazepineCytochrome P450 2B6enzyme
CarbamazepineCytochrome P450 3A4enzyme
CarbamazepineCytochrome P450 1A2enzyme
CarbamazepineCytochrome P450 2C19enzyme
CarbamazepineCytochrome P450 2C9enzyme
CarbamazepineP-glycoprotein 1transporter
CarbamazepineCytochrome P450 3A5enzyme
CarbamazepineUDP-glucuronosyltransferase 2B7enzyme
CarbamazepineRalA-binding protein 1transporter
CarbamazepineCanalicular multispecific organic anion transporter 1transporter
CarbamazepineNeuronal acetylcholine receptor subunit alpha-4target
CarbamazepineNuclear receptor subfamily 1 group I member 2target
CarbamazepineUDP-glucuronosyltransferase 1-1enzyme
CarbamazepineUDP-glucuronosyltransferase 1-6enzyme
CarbamazepineUDP-glucuronosyltransferase 1-7enzyme
Valproic acidHistone deacetylase 9target
Valproic acidShort/branched chain specific acyl-CoA dehydrogenase, mitochondrialtarget
Valproic acidCytochrome P450 2A6enzyme
Valproic acidCytochrome P450 2B6enzyme
Valproic acidCytochrome P450 2C9enzyme
Valproic acidSolute carrier family 22 member 5transporter
Valproic acidSolute carrier family 22 member 6transporter
Valproic acidSolute carrier family 22 member 8transporter
Valproic acidMonocarboxylate transporter 1transporter
Valproic acidSolute carrier family 22 member 7transporter
Valproic acidCytochrome P450 3A5enzyme
Valproic acidUDP-glucuronosyltransferase 1-9enzyme
Valproic acidProstaglandin G/H synthase 1enzyme
Valproic acidCytochrome P450 1A2enzyme
Valproic acidCytochrome P450 2C19enzyme
Valproic acidCytochrome P450 3A4enzyme
Valproic acidUDP-glucuronosyltransferase 1-4enzyme
Valproic acidUDP-glucuronosyltransferase 1-8enzyme
Valproic acidUDP-glucuronosyltransferase 1-10enzyme
Valproic acidUDP-glucuronosyltransferase 1-6enzyme
Valproic acidUDP-glucuronosyltransferase 1-3enzyme
Valproic acidUDP-glucuronosyltransferase 2B7enzyme
Valproic acidUDP-glucuronosyltransferase 2B15enzyme
Valproic acid2-oxoglutarate dehydrogenase, mitochondrialtarget
Valproic acidSuccinate-semialdehyde dehydrogenase, mitochondrialtarget
Valproic acidSodium channel proteintarget
Valproic acidHistone deacetylase 2target
Valproic acidPeroxisome proliferator-activated receptor alphatarget
Valproic acidPeroxisome proliferator-activated receptor deltatarget
Valproic acidPeroxisome proliferator-activated receptor gammatarget
Valproic acidSerum albumincarrier
Valproic acidUDP-glucuronosyltransferase 1-1enzyme
Valproic acidSolute carrier organic anion transporter family member 2B1transporter
IrinotecanDNA topoisomerase I, mitochondrialtarget
IrinotecanDNA topoisomerase 1target
IrinotecanCytochrome P450 3A4enzyme
IrinotecanCytochrome P450 3A5enzyme
IrinotecanUDP-glucuronosyltransferase 1-1enzyme
IrinotecanUDP-glucuronosyltransferase 1-9enzyme
IrinotecanLiver carboxylesterase 1enzyme
IrinotecanCytochrome P450 3A7enzyme
IrinotecanCytochrome P450 2B6enzyme
IrinotecanSolute carrier family 22 member 3transporter
IrinotecanSolute carrier organic anion transporter family member 1B1transporter
IrinotecanMultidrug resistance-associated protein 1transporter
IrinotecanATP-binding cassette sub-family G member 2transporter
IrinotecanSerum albumincarrier
IrinotecanCocaine esteraseenzyme
IrinotecanCholinesteraseenzyme
IrinotecanP-glycoprotein 1transporter
IrinotecanCanalicular multispecific organic anion transporter 1transporter
AmitriptylineSodium-dependent serotonin transportertarget
AmitriptylineSodium-dependent noradrenaline transportertarget
AmitriptylinePotassium voltage-gated channel subfamily KQT member 2target
AmitriptylineAlpha-2A adrenergic receptortarget
AmitriptylineCytochrome P450 1A2enzyme
AmitriptylineCytochrome P450 2C19enzyme
AmitriptylineCytochrome P450 2D6enzyme
AmitriptylineSerum albumincarrier
AmitriptylineAlpha-1-acid glycoprotein 1carrier
AmitriptylineHistamine H1 receptortarget
Amitriptyline5-hydroxytryptamine receptor 2Atarget
Amitriptyline5-hydroxytryptamine receptor 1Atarget
AmitriptylineAlpha-1A adrenergic receptortarget
AmitriptylineCytochrome P450 3A4enzyme
AmitriptylineCytochrome P450 3A5enzyme
AmitriptylinePotassium voltage-gated channel subfamily A member 1target
AmitriptylineAlpha-1D adrenergic receptortarget
AmitriptylineDelta-type opioid receptortarget
AmitriptylineKappa-type opioid receptortarget
AmitriptylineHigh affinity nerve growth factor receptortarget
AmitriptylineBDNF/NT-3 growth factors receptortarget
AmitriptylineCytochrome P450 2C9enzyme
AmitriptylineCytochrome P450 2B6enzyme
AmitriptylineCytochrome P450 2C8enzyme
AmitriptylineHistamine H2 receptortarget
AmitriptylineHistamine H4 receptortarget
AmitriptylineSigma non-opioid intracellular receptor 1target
Amitriptyline5-hydroxytryptamine receptor 2Ctarget
AmitriptylineAlpha-1B adrenergic receptortarget
Amitriptyline5-hydroxytryptamine receptor 7target
Amitriptyline5-hydroxytryptamine receptor 1Dtarget
AmitriptylineMu-type opioid receptortarget
Amitriptyline5-hydroxytryptamine receptor 1Btarget
Amitriptyline5-hydroxytryptamine receptor 6target
AmitriptylinePotassium voltage-gated channel subfamily KQT member 3target
AmitriptylineUDP-glucuronosyltransferase 2B10enzyme
Amitriptyline5-hydroxytryptamine receptor 1Ctarget
AmitriptylineMuscarinic acetylcholine receptortarget
AmitriptylineHERG human cardiac K+ channeltarget
AmitriptylineP-glycoprotein 1transporter
AmitriptylineUDP-glucuronosyltransferase 1-4enzyme
ImipramineSodium-dependent noradrenaline transportertarget
ImipramineSodium-dependent serotonin transportertarget
ImipramineCytochrome P450 1A2enzyme
ImipramineCytochrome P450 2C19enzyme
ImipramineCytochrome P450 2D6enzyme
ImipramineHistamine H1 receptortarget
ImipramineAlpha-1A adrenergic receptortarget
Imipramine5-hydroxytryptamine receptor 2Atarget
ImipramineMuscarinic acetylcholine receptor M1target
ImipramineMuscarinic acetylcholine receptor M2target
ImipramineMuscarinic acetylcholine receptor M3target
ImipramineMuscarinic acetylcholine receptor M4target
ImipramineMuscarinic acetylcholine receptor M5target
ImipraminePotassium voltage-gated channel subfamily D member 2target
ImipraminePotassium voltage-gated channel subfamily D member 3target
ImipramineAlpha-1D adrenergic receptortarget
ImipramineAlpha-1-acid glycoprotein 1carrier
ImipramineSolute carrier family 22 member 2transporter
ImipramineSolute carrier family 22 member 3transporter
ImipramineP-glycoprotein 1transporter
ImipramineSolute carrier family 22 member 4transporter
ImipramineCytochrome P450 3A4enzyme
ImipramineCytochrome P450 2B6enzyme
ImipramineCytochrome P450 2C18enzyme
ImipramineCytochrome P450 2E1enzyme
ImipramineCytochrome P450 3A7enzyme
Imipramine5-hydroxytryptamine receptor 2Ctarget
ImipramineAlpha-1B adrenergic receptortarget
Imipramine5-hydroxytryptamine receptor 7target
ImipramineD(1) dopamine receptortarget
ImipramineDopamine D2 receptortarget
ImipraminePotassium voltage-gated channel subfamily H member 2target
ImipramineSodium-dependent dopamine transportertarget
Imipramine5-hydroxytryptamine receptor 1Atarget
Imipramine5-hydroxytryptamine receptor 6target
ImipraminePotassium voltage-gated channel subfamily H member 1target
ImipramineSerum albumincarrier
ImipramineAlpha-1-acid glycoprotein 2target
RomidepsinCytochrome P450 3A4enzyme
RomidepsinCytochrome P450 3A5enzyme
RomidepsinP-glycoprotein 1transporter
RomidepsinSolute carrier organic anion transporter family member 1B3transporter
RomidepsinCytochrome P450 1A1enzyme
RomidepsinCytochrome P450 2B6enzyme
RomidepsinCytochrome P450 2C19enzyme
RomidepsinHistone deacetylase 1target
RomidepsinHistone deacetylase 2target
RomidepsinHistone deacetylase 4target
RomidepsinHistone deacetylase 6target
RomidepsinMultidrug resistance-associated protein 1target