Cytochrome P-450 CYP3A7 Substrates with a Narrow Therapeutic Index
- Cytochrome P-450 CYP3A7 Substrates with a Narrow Therapeutic Index
- Accession Number
Drug Drug Description Pimozide An antipsychotic used to manage debilitating motor and phonic tics in patients with Tourette's Disorder. Quinidine A medication used to restore normal sinus rhythm, treat atrial fibrillation and flutter, and treat ventricular arrhythmias. Sirolimus An immunosuppressant used to prevent organ transplant rejections and to treat lymphangioleiomyomatosis. Temsirolimus A antineoplastic agent used in the treatment of renal cell carcinoma (RCC) that works by inhibiting mTOR. Paclitaxel A taxoid chemotherapeutic agent used as first-line and subsequent therapy for the treatment of advanced carcinoma of the ovary, and other various cancers including breast and lung cancer. Docetaxel A taxoid antineoplastic agent used in the treatment of various cancers, such as locally advanced or metastatic breast cancer, metastatic prostate cancer, gastric adenocarcinoma, and head and neck cancer. Tamoxifen A selective estrogen receptor modulator used to treat estrogen receptor positive breast cancer, reduce the risk of invasive breast cancer following surgery, or reduce the risk of breast cancer in high risk women. Sunitinib A receptor tyrosine kinase inhibitor and chemotherapeutic agent used for the treatment of renal cell carcinoma (RCC) and imatinib-resistant gastrointestinal stromal tumor (GIST). Sorafenib A kinase inhibitor used in the treatment of unresectable liver carcinoma and advanced renal carcinoma. Astemizole A second generation antihistamine used to treat allergy symptoms. Irinotecan An antineoplastic enzyme inhibitor used to treat metastatic carcinoma of the colon or rectum. Levacetylmethadol For the treatment and management of opiate dependence. It is sometimes used to treat severe pain in terminal patients. Vincristine A vinca alkaloid used to treat acute leukemia, malignant lymphoma, Hodgkin's disease, acute erythraemia, and acute panmyelosis. Imipramine A tricyclic antidepressant indicated for the treatment of depression and to reduce childhood enuresis. Phenytoin An anticonvulsant drug used in the prophylaxis and control of various types of seizures. Idelalisib An antineoplastic kinase inhibitor used to treat chronic lymphocytic leukemia (CLL), relapsed follicular B-cell non-Hodgkin lymphoma (FL), and relapsed small lymphocytic lymphoma (SLL). Copanlisib A medication used to treat relapsed follicular lymphoma who have attempted at least two other treatments.
- Drugs & Drug Targets