Cytochrome P-450 CYP3A7 Substrates
- Cytochrome P-450 CYP3A7 Substrates
- Accession Number
Drug Drug Description Clarithromycin A macrolide antibiotic used for the treatment of a wide variety of bacterial infections such as acute otitis, pharyngitis, tonsillitis, respiratory tract infections, uncomplicated skin infections, and helicobacter pylori infection. Erythromycin A macrolide antibiotic used to treat and prevent a variety of bacterial infections. Telithromycin An ketolide used to treat community acquired pneumonia of mild to moderate severity. Quinidine A medication used to restore normal sinus rhythm, treat atrial fibrillation and flutter, and treat ventricular arrhythmias. Alprazolam A triazolobenzodiazepine with intermediate onset commonly used to treat panic disorders and generalized anxiety in addition to anxiety associated with depression. Diazepam A long-acting benzodiazepine with rapid onset commonly used to treat panic disorders, severe anxiety, alcohol withdrawal, and seizures. Triazolam A benzodiazepine used for short term treatment of insomnia. Saquinavir An HIV protease inhibitor used in combination with other antiretroviral agents for the treatment of HIV-1 with advanced immunodeficiency. Cisapride A medication used to treat heartburn associated with GERD. Astemizole A second generation antihistamine used to treat allergy symptoms. Chlorpheniramine A histamine-H1 receptor antagonist indicated for the management of symptoms associated with upper respiratory allergies. Diltiazem A calcium channel blocker used to treat hypertension and to manage chronic stable angina. Felodipine A calcium channel blocker used to treat hypertension. Nifedipine A dihydropyridine calcium channel blocker indicated for the management of several subtypes of angina pectoris, and hypertension. Nisoldipine A calcium channel blocker used as monotherapy or combined with other drugs for the treatment of hypertension. Nitrendipine A dihydropyridine calcium channel blocker indicated in the treatment of arterial hypertension. Atorvastatin An HMG-CoA reductase inhibitor used to lower lipid levels and reduce the risk of cardiovascular disease including myocardial infarction and stroke. Lovastatin An HMG-CoA reductase inhibitor used to lower LDL cholesterol and reduce the risk of cardiovascular disease and associated conditions, including myocardial infarction and stroke. Simvastatin An HMG-CoA reductase inhibitor used to lower lipid levels and reduce the risk of cardiovascular events including myocardial infarction and stroke. Alfentanil An opioid agonist used to induce and maintain anesthesia, as well as an analgesic. Aripiprazole An atypical antipsychotic used in the treatment of a wide variety of mood and psychotic disorders, such as schizophrenia, bipolar I, major depressive disorder, irritability associated with autism, and Tourette's syndrome. Buspirone An anxiolytic agent used for short-term treatment of generalized anxiety and second-line treatment of depression. Imatinib A tyrosine kinase inhibitor used to treat a number of leukemias, myelodysplastic/myeloproliferative disease, systemic mastocytosis, hypereosinophilic syndrome, dermatofibrosarcoma protuberans, and gastrointestinal stromal tumors. Haloperidol An antipsychotic agent used to treat schizophrenia and other psychoses, as well as symptoms of agitation, irritability, and delirium. Pimozide An antipsychotic used to manage debilitating motor and phonic tics in patients with Tourette's Disorder. Quinine An alkaloid used to treat uncomplicated Plasmodium falciparum malaria. Sildenafil A phosphodiesterase inhibitor used for the treatment of erectile dysfunction. Sirolimus An mTOR inhibitor immunosuppressant used to prevent organ transplant rejections, treat lymphangioleiomyomatosis, and treat adults with perivascular epithelioid cell tumors. Tamoxifen A selective estrogen receptor modulator used to treat estrogen receptor positive breast cancer, reduce the risk of invasive breast cancer following surgery, or reduce the risk of breast cancer in high risk women. Trazodone A serotonin uptake inhibitor used to treat major depressive disorder. Vincristine A vinca alkaloid used to treat acute leukemia, malignant lymphoma, Hodgkin's disease, acute erythraemia, and acute panmyelosis. Ritonavir An HIV protease inhibitor used in combination with other antivirals in the treatment of HIV infection. Hydrocortisone A glucocorticoid used to treat corticosteroid-responsive dermatoses, endocrine disorders, immune conditions, and allergic disorders. Hydrocortisone aceponate For the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses. Also used to treat endocrine (hormonal) disorders (adrenal insufficiency, Addisons disease). It is also used to treat many... Hydrocortisone acetate A corticosteroid used to treat inflammatory and pruritic corticosteroid-responsive dermatoses and ulcerative colitis. Hydrocortisone butyrate A corticosteroid used to treat inflammatory and pruritic corticosteroid-responsive dermatoses. Hydrocortisone cypionate For the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses. Also used to treat endocrine (hormonal) disorders (adrenal insufficiency, Addisons disease). It is also used to treat many... Hydrocortisone phosphate A corticosteroid used to treat congenital adrenal hyperplasia, for emergency asthma treatment, hypersensitivity, and inflammation. Hydrocortisone probutate A corticosteroid used to treat inflammatory and pruritic corticosteroid-responsive dermatoses. Hydrocortisone valerate A corticosteroid used to treat inflammatory and pruritic corticosteroid-responsive dermatoses. Norethisterone A synthetic second-generation progestin used for contraception, prevention of endometrial hyperplasia in hormone replacement therapy, and in the treatment of other hormone-mediated illnesses such as endometriosis. Prasterone A steroid formulated as a vaginal insert indicated for the treatment of moderate to severe dyspareunia associated with menopausal vulvar and vaginal atrophy. Prasterone sulfate Investigated for use/treatment in asthma and burns and burn infections. Progesterone A hormone used for a variety of functions, including contraception, control of abnormal uterine bleeding, maintenance of pregnancy, and prevention of endometrial hyperplasia. Risperidone A second-generation antipsychotic medication used to treat a number of mental health disorders including schizophrenia, bipolar mania, psychosis, or as an adjunct in severe depression. Fentanyl An opioid analgesic used in anesthesia, for breakthrough cancer pain, or round the clock pain management. Temsirolimus A antineoplastic agent used in the treatment of renal cell carcinoma (RCC) that works by inhibiting mTOR. Terfenadine An antihistamine for the treatment of allergy symptoms. Lercanidipine A calcium channel blocker for the management of hypertension. Cerivastatin A statin (or HMG CoA reductase inhibitor) used with dietary changes to decrease lipid levels and reduce the risk of cardiovascular events. Estradiol An estrogenic steroid used to treat vasomotor symptoms of vulvar and vaginal atrophy in menopause, hypoestrogenism, prevention of postmenopausal osteoporosis, treatment of breast cancer, and advanced androgen-dependent carcinoma of the prostate. Testosterone A hormone used to treat hypogonadism, breast carcinoma in women, or the vasomotor symptoms of menopause. Aprepitant A substance P/neurokinin 1 receptor antagonist used to treat nausea and vomiting caused by chemotherapy and surgery. Cilostazol An antiplatelet agent and vasodilator used for the symptomatic relief of intermittent claudication. Dapsone A sulfone drug used to treat acne vulgaris, Hansen's disease, and dermatitis herpetiformis. Dextromethorphan An NMDA receptor antagonist used to treat cases of dry cough. Docetaxel A taxoid antineoplastic agent used in the treatment of various cancers, such as locally advanced or metastatic breast cancer, metastatic prostate cancer, gastric adenocarcinoma, and head and neck cancer. Domperidone A dopamine receptor antagonist used as a peristaltic stimulant and anti-emetic agent for dyspepsia, indigestion, epigastric pain, nausea, and vomiting. Eplerenone An aldosterone receptor antagonist used to improve survival of patients with symptomatic heart failure and to reduce blood pressure. Finasteride An antiandrogenic compound that is used for the treatment of symptomatic benign prostatic hyperplasia (BPH) and male pattern hair loss in adult males by inhibiting Type II 5-alpha reductase. Irinotecan An antineoplastic enzyme inhibitor used to treat metastatic carcinoma of the colon or rectum. Levacetylmethadol For the treatment and management of opiate dependence. It is sometimes used to treat severe pain in terminal patients. Lidocaine A local anesthetic used in a wide variety of superficial and invasive procedures. Methadone An opioid analgesic indicated for management of severe pain that is not responsive to alternative treatments. Also used to aid in detoxification and maintenance treatment of opioid addiction. Nateglinide A meglitinide used to treat non insulin dependent diabetes mellitus. Ondansetron A serotonin 5-HT3 receptor antagonist used to prevent nausea and vomiting in cancer chemotherapy and postoperatively. Propranolol A non-selective beta adrenergic antagonist used to treat hypertension, angina, atrial fibrillation, myocardial infarction, migraine, essential tremor, hypertrophic subaortic stenosis, and pheochromocytoma. Quetiapine A psychotropic agent used for the management of bipolar disorder, schizophrenia, and major depressive disorder. Salmeterol A long-acting beta-2 adrenergic receptor agonist used to treat asthma and COPD. Sorafenib A kinase inhibitor used to treat unresectable liver carcinoma, advanced renal carcinoma, and differentiated thyroid carcinoma. Sunitinib A receptor tyrosine kinase inhibitor and chemotherapeutic agent used for the treatment of renal cell carcinoma (RCC) and imatinib-resistant gastrointestinal stromal tumor (GIST). Paclitaxel A taxoid chemotherapeutic agent used as first-line and subsequent therapy for the treatment of advanced carcinoma of the ovary, and other various cancers including breast and lung cancer. Zaleplon A sedative used for short term treatment of insomnia in adults. Buprenorphine A partial opioid agonist used for management of severe pain that is not responsive to alternative treatments. Also used for maintenance treatment of opioid addiction. Imipramine A tricyclic antidepressant indicated for the treatment of depression and to reduce childhood enuresis. Praziquantel An anthelmintic medication used to treat a number of parasitic worm infections such as schistosomiasis. Fluticasone propionate A glucocorticoid used to treat asthma, inflammatory pruritic dermatoses, and nonallergic rhinitis. Tretinoin A vitamin A derivative used to treat acne vulgaris and certain types of promyelocytic leukemia, as well as various skin conditions in over-the-counter medications. Iloperidone An atypical antipsychotic agent used for the acute treatment of schizophrenia in adults. Daclatasvir A direct-acting antiviral agent used to treat specific hepatitis C virus (HCV) infections in combination with other antiviral agents. Idelalisib An antineoplastic kinase inhibitor used to treat chronic lymphocytic leukemia (CLL), relapsed follicular B-cell non-Hodgkin lymphoma (FL), and relapsed small lymphocytic lymphoma (SLL). Cobicistat A CYP3A inhibitor used to increase the systemic exposure of atazanavir or darunavir in combination with other antiretroviral agents in the treatment of HIV-1 infection. Elbasvir An antiviral and NS5A inhibitor used to treat hepatitis C infections. Copanlisib A medication used to treat relapsed follicular lymphoma who have attempted at least two other treatments. Testosterone cypionate An androgen used to treat low or absent testosterone. Testosterone enanthate An androgen used to treat low or absent testosterone. Testosterone undecanoate An androgen indicated for testosterone replacement therapy in adult males with primary hypogonadism and hypogonadotropic hypogonadism. Estradiol acetate An estrogen used to treat vasomotor symptoms and moderate to severe vulvar and vaginal atrophy from menopause. Estradiol benzoate An estrogen indicated in combination with progesterone for the treatment of irregular menstruation. Estradiol cypionate An estradiol prodrug used to treat vasomotor symptoms and hypoestrogenisms from hypogonadism. Estradiol dienanthate An estrogen used in some combined hormonal oral contraceptives. Estradiol valerate An estradiol prodrug used to treat some effects of menopause, hypoestrogenism, androgen dependant carcinoma of the prostate, and in combination products for endometriosis and contraception. Aripiprazole lauroxil An antipsychotic used to treat schizophrenia in adults. Fluticasone A corticosteroid indicated in the treatment of corticosteroid responsive dermatoses, asthma, and COPD. Fluticasone furoate An inhaled corticosteroid that can be used as maintenance treatment of asthma and/or chronic obstructive pulmonary disease (COPD) depending on the product. Also available as a nasal spray to manage symptoms of allergic rhinitis. Metronidazole A nitroimidazole used to treat trichomoniasis, amebiasis, inflammatory lesions of rosacea, and bacterial infections, as well as prevent postoperative infections. Midazolam A short-acting benzodiazepine with rapid onset that is commonly used in seizures, anesthesia and anxiety disorders. Nevirapine A non-nucleoside reverse transcriptase inhibitor used as part of a management regimen for HIV-1 virus infection. Glyburide A sulfonylurea used in the treatment of non insulin dependent diabetes mellitus. Triamcinolone A glucocorticoid used to treat a wide variety of inflammatory conditions of organ systems and tissues. Dexamethasone A glucocorticoid available in various modes of administration that is used for the treatment of various inflammatory conditions, including bronchial asthma, as well as endocrine and rheumatic disorders. Levamlodipine A calcium channel blocker used to treat hypertension. Phenytoin An anticonvulsant drug used in the prophylaxis and control of various types of seizures. Dexamethasone acetate Commonly known as decadron, dexamethasone acetate is a glucocorticosteroid previously marketed in the USA for the treatment of inflammatory respiratory, allergic, autoimmune, and other conditions.[T797,L10695,L14348] Developed in 1957, dexamethasone is... Risdiplam An oral mRNA splicing modifier used in the treatment of spinal muscular atrophy (SMA). Relugolix An oral GnRH receptor antagonist for androgen deprivation therapy in the treatment of advanced prostate cancer. Voriconazole A triazole compound used to treat fungal infections. Mobocertinib An oral kinase inhibitor targeted against EGFR and used in the treatment of NSCLC with EGFR exon 20 insertion mutations. Clobazam A benzodiazepine used as adjunct treatment in seizures associated with Lennox-Gastaut syndrome.
- Drugs & Drug Targets