Central Nervous System Stimulation

Accession Number

DBCAT004212

Description

Not Available

Drugs

Drug	Drug Description
Lisdexamfetamine	A central nervous system (CNS) stimulant used to treat attention deficit hyperactivity disorder (ADHD) and moderate to severe eating disorders.
Caffeine	A stimulant present in tea, coffee, cola beverages, analgesic drugs, and agents used to increase alertness. It is also used in to prevent and treat pulmonary complications of premature birth.
Modafinil	A stimulant used to improve wakefulness in patients with sleep apnea, narcolepsy, or shift work disorder.
Amphetamine	A CNS stimulant and sympathomimetic agent indicated for the treatment of Attention Deficit Hyperactivity Disorder (ADHD).
Metamfetamine	A sympathomimetic agent used in the treatment of attention deficit hyperactivity disorder (ADHD) and exogenous obesity.
Dextroamphetamine	A sympathomimetic agent used in the treatment of attention deficit hyperactivity disorder (ADHD) and narcolepsy.
Dexmethylphenidate	A norepinephrine-dopamine reuptake inhibitor used in the treatment of ADHD in conjunction with other therapies.
Methylphenidate	A stimulant used in the management of Attention Deficit Hyperactivity Disorder (ADHD).
Serdexmethylphenidate	A prodrug of the CNS stimulant dexmethylphenidate used as a first-line treatment for Attention Deficit Hyperactivity Disorder (ADHD).

Drugs & Drug Targets

Drug	Target	Type
Lisdexamfetamine	Solute carrier family 15 member 1	transporter
Lisdexamfetamine	Trace amine-associated receptor 1	target
Caffeine	Adenosine receptor A1	target
Caffeine	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	target
Caffeine	Adenosine receptor A2a	target
Caffeine	Cytochrome P450 1A2	enzyme
Caffeine	Ryanodine receptor 1	target
Caffeine	Cytochrome P450 3A4	enzyme
Caffeine	Cytochrome P450 2E1	enzyme
Caffeine	Cytochrome P450 2C8	enzyme
Caffeine	Cytochrome P450 2C9	enzyme
Caffeine	Cytochrome P450 1A1	enzyme
Caffeine	Cytochrome P450 1B1	enzyme
Caffeine	Cytochrome P450 2D6	enzyme
Caffeine	Cyclic nucleotide phosphodiesterase	target
Caffeine	DNA-dependent protein kinase catalytic subunit	target
Caffeine	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	target
Caffeine	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	target
Caffeine	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	target
Caffeine	Inositol 1,4,5-trisphosphate receptor	target
Caffeine	Serine-protein kinase ATM	target
Caffeine	ATP-binding cassette sub-family G member 2	transporter
Caffeine	Adenosine receptor A2b	target
Caffeine	Adenosine receptor A3	target
Caffeine	Phosphodiesterase enzymes	target
Modafinil	Sodium-dependent dopamine transporter	target
Modafinil	Alpha-1B adrenergic receptor	target
Modafinil	Cytochrome P450 3A4	enzyme
Modafinil	Cytochrome P450 2C19	enzyme
Modafinil	Cytochrome P450 1A2	enzyme
Modafinil	Cytochrome P450 2B6	enzyme
Modafinil	Cytochrome P450 2C9	enzyme
Modafinil	Cytochrome P450 3A5	enzyme
Modafinil	Cytochrome P450 2D6	enzyme
Amphetamine	Sodium-dependent dopamine transporter	target
Amphetamine	Cocaine- and amphetamine-regulated transcript protein	target
Amphetamine	Trace amine-associated receptor 1	target
Amphetamine	Cytochrome P450 2D6	enzyme
Amphetamine	Solute carrier family 22 member 3	transporter
Amphetamine	Solute carrier family 22 member 5	transporter
Amphetamine	Synaptic vesicular amine transporter	target
Amphetamine	Cytochrome P450 2A6	enzyme
Amphetamine	Sodium-dependent noradrenaline transporter	target
Amphetamine	Alpha adrenergic receptor	target
Amphetamine	Beta adrenergic receptor	target
Amphetamine	Dopamine D2 receptor	target
Amphetamine	Amine oxidase [flavin-containing] B	target
Amphetamine	Sodium-dependent serotonin transporter	target
Amphetamine	Monoamine oxidase	target
Metamfetamine	Cytochrome P450 2D6	enzyme
Metamfetamine	Solute carrier family 22 member 3	transporter
Metamfetamine	Solute carrier family 22 member 5	transporter
Metamfetamine	Sodium-dependent dopamine transporter	target
Metamfetamine	Synaptic vesicular amine transporter	target
Metamfetamine	Trace amine-associated receptor 1	target
Metamfetamine	Sodium-dependent serotonin transporter	target
Metamfetamine	Sodium-dependent noradrenaline transporter	target
Metamfetamine	Chromaffin granule amine transporter	target
Metamfetamine	Amine oxidase [flavin-containing] A	target
Metamfetamine	Amine oxidase [flavin-containing] B	target
Metamfetamine	Alpha-2A adrenergic receptor	target
Metamfetamine	Alpha-2B adrenergic receptor	target
Metamfetamine	Alpha-2C adrenergic receptor	target
Dextroamphetamine	Alpha-1B adrenergic receptor	target
Dextroamphetamine	Sodium-dependent dopamine transporter	target
Dextroamphetamine	Sodium-dependent noradrenaline transporter	target
Dextroamphetamine	Synaptic vesicular amine transporter	target
Dextroamphetamine	Trace amine-associated receptor 1	target
Dextroamphetamine	Cytochrome P450 2D6	enzyme
Dextroamphetamine	Primary amine oxidase	enzyme
Dextroamphetamine	Sodium-dependent dopamine transporter	transporter
Dextroamphetamine	Alpha adrenergic receptor	target
Dexmethylphenidate	Sodium-dependent dopamine transporter	target
Dexmethylphenidate	Sodium-dependent noradrenaline transporter	target
Dexmethylphenidate	Sodium-dependent serotonin transporter	target
Dexmethylphenidate	Carboxylesterase	enzyme
Methylphenidate	Sodium-dependent dopamine transporter	target
Methylphenidate	Sodium-dependent noradrenaline transporter	target
Methylphenidate	Carboxylesterase	enzyme
Methylphenidate	5-hydroxytryptamine receptor 1A	target
Serdexmethylphenidate	Sodium-dependent dopamine transporter	target
Serdexmethylphenidate	Sodium-dependent noradrenaline transporter	target
Serdexmethylphenidate	5-hydroxytryptamine receptor 1A	target
Serdexmethylphenidate	Carboxylesterase	enzyme