PD-1/PDL-1 (Programmed cell death protein 1/death ligand 1) inhibitors

Name
PD-1/PDL-1 (Programmed cell death protein 1/death ligand 1) inhibitors
Accession Number
DBCAT005748
Description

Not Available

Drugs
DrugDrug Description
NivolumabA PD-1 blocking antibody used to treat melanoma, non small-cell lung cancer, renal cell cancer, head and neck cancer, and Hodgkin lymphoma.
PembrolizumabA PD-1 blocking antibody used to treat various types of cancer, including metastatic melanoma, non small-cell lung cancer, cervical cancer, head and neck cancer, and Hodgkin's lymphoma.
AtezolizumabA monoclonal antibody used to treat advanced or metastatic urothelial carcinoma with disease progression during or up to 12 months after platinum-containing chemotherapy.
DurvalumabAn antineoplastic monoclonal antibody used to treat urothelial carcinoma and locally advanced, unresectable non-small cell lung cancer.
AvelumabAn anti-PD-L1 monoclonal antibody used to treat metastatic merkel cell carcinoma, metastatic urothelial carcinoma, or renal cell carcinoma.
CemiplimabA programmed death receptor-1 blocking antibody used to treat cutaneous squamous cell carcinoma, basal cell carcinoma, and non-small cell lung cancer.
TislelizumabAn IgG4 variant monoclonal antibody against PD-1 indicated for the treatment of unresectable, locally advanced or metastatic esophageal squamous cell carcinoma
DostarlimabAn anti-PD-1 monoclonal antibody used in the treatment of mismatch repair deficient endometrial cancers and solid tumours with no alternative treatment options.
RetifanlimabA PD-1–blocking antibody indicated for the treatment of adult patients with metastatic or recurrent locally advanced Merkel cell carcinoma.
ProlgolimabNot Annotated
Drugs & Drug Targets
DrugTargetType
NivolumabProgrammed cell death protein 1target
NivolumabProgrammed cell death 1 ligand 1target
PembrolizumabProgrammed cell death protein 1target
PembrolizumabProgrammed cell death 1 ligand 1target
AtezolizumabProgrammed cell death 1 ligand 1target
AtezolizumabProgrammed cell death protein 1target
DurvalumabProgrammed cell death 1 ligand 1target
DurvalumabProgrammed cell death protein 1target
AvelumabProgrammed cell death 1 ligand 1target
CemiplimabProgrammed cell death protein 1target
TislelizumabProgrammed cell death protein 1target
DostarlimabProgrammed cell death protein 1target
RetifanlimabProgrammed cell death protein 1target
ProlgolimabProgrammed cell death protein 1target