Trachoma (DBCOND0000280)

Identifiers

Synonyms

Trachoma, unspecified / Trachoma (disorder)

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Acetyl sulfisoxazole	Acute, recurrent or chronic urinary tract infections (primarily pyelonephritis, pyelitis and cystitis) due to susceptible organisms (usually Escherichia coli, Klebsiella-Enterobacter, staphylococcus, Proteus mirabilis and, less frequently, Proteus vulgaris) in the...	Dihydropteroate synthasetarget Cytochrome P450 2C9enzyme
Chloramphenicol	A broad spectrum antibiotic that is effective against a variety of susceptible and serious bacterial infections but is not frequently used because of its high risk of bone marrow toxicity.	Complement decay-accelerating factortarget Dr hemagglutinin structural subunittarget Cytochrome P450 2C19enzyme Cytochrome P450 3A4enzyme Cytochrome P450 3A5enzyme Cytochrome P450 3A7enzyme Solute carrier family 22 member 6transporter 50S ribosomal protein L16target Chloramphenicol acetyltransferase 3enzyme Chloramphenicol acetyltransferaseenzyme Chloramphenicol 3-O phosphotransferaseenzyme
Minocycline	A tetracycline analog used to treat a wide variety of infections in the body.	30S ribosomal protein S4target 30S ribosomal protein S9target 16S ribosomal RNAtarget Interleukin-1 betatarget Polyunsaturated fatty acid 5-lipoxygenasetarget Matrix metalloproteinase-9target Vascular endothelial growth factor A, long formtarget Caspase-1target Caspase-3target Cytochrome ctarget Solute carrier family 22 member 6transporter Solute carrier family 22 member 7transporter Outer membrane protein Ftransporter Outer membrane porin Ctransporter Mitogen-activated Protein Kinasestarget Nitric oxide synthase, inducibletarget
Sulfacetamide	A sulfonamide used to treat inflammatory ocular conditions and acne vulgaris.	Dihydropteroate synthasetarget Dihydropteroate synthase type-1target Folic acid synthesis protein FOL1target
Sulfadiazine	A sulfonamide antibiotic used in a variety of infections, such as urinary tract infections, trachoma, and chancroid.	Cytochrome P450 2C9enzyme Dihydropteroate synthetasetarget Cytochrome P450 2C8enzyme Cytochrome P450 3A4enzyme Dihydropteroate synthasetarget
Sulfamethylthiazole	An antibiotic indicated to prevent postoperative ocular infections or treat ocular infections.	No drug targets
Tetracycline	An antibiotic used to treat a wide variety of susceptible infections.	16S ribosomal RNAtarget Major prion proteintarget Albumincarrier Cytochrome P450 3A4enzyme Solute carrier family 22 member 6transporter Organic anion transporter 3transporter Solute carrier family 22 member 11transporter Solute carrier family 22 member 7transporter 30S ribosomal protein S3target 30S ribosomal protein S8target 30S ribosomal protein S19target 30S ribosomal protein S14target 30S ribosomal protein S7target Multidrug translocase MdfAtarget Protein-arginine deiminase type-4target Solute carrier organic anion transporter family member 2B1transporter

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT04185402	Azithromycin Reduction to Reach Elimination of Trachoma	Azithromycin	treatment	4	recruiting
NCT03997487	Smartphone App for Taking Images of Conjunctivae	No drug interventions	other	Not Available	terminated
NCT01949454	Fluorometholone as Ancillary Therapy for TT Surgery	Fluorometholone	treatment	Not Available	completed
NCT06289647	Azithromycin Reduction to Reach Elimination of Trachoma B	Azithromycin	treatment	4	not_yet_recruiting
NCT00348478	Impact of Water and Health Education Programs on Trachoma and Ocular C. Trachomatis in Niger	No drug interventions	prevention	4	completed
NCT00886015	Modified Instrumentation for Surgery to Correct Trichiasis	No drug interventions	treatment	Not Available	completed
NCT00618449	Impact of Two Alternative Dosing Strategies for Trachoma Control in Niger	Azithromycin	treatment	4	completed
NCT01202331	Tripartite International Research for the Elimination of Trachoma	Azithromycin	treatment	4	completed
NCT03570814	Cluster RCT of Co-administration Azithromycin, Albendazole & Ivermectin	Albendazole Azithromycin Ivermectin	treatment	4	completed
NCT00221364	Trachoma Elimination Follow-up	Azithromycin	treatment	4	completed
NCT02754583	Sanitation, Water, and Instruction in Face-washing for Trachoma I/II	Azithromycin Tetracycline	treatment	3	recruiting
NCT03926728	Safety and Immunogenicity of a Chlamydia Vaccine CTH522	No drug interventions	prevention	1	completed
NCT00347607	Study of Three Alternatives for Mass Treatment in Trachoma Villages of Tanzania	No drug interventions	treatment	4	completed
NCT03523156	Trachoma Elimination Study by Focused Antibiotic (TESFA)	Azithromycin	treatment	4	suspended
NCT02655432	Performance of a Photoscreener for Vision Screening in a Haitian Pediatric Population	No drug interventions	Not Available	Not Available	withdrawn
NCT05634759	Enhancing the A in SAFE for Trachoma	Azithromycin	treatment	4	completed
NCT01767506	A Surveillance and Azithromycin Treatment for Newcomers and Travelers Evaluation: The ASANTE Trial	No drug interventions	treatment	Not Available	completed
NCT00347763	Effect of Intensive Fly Control on Trachoma and Ocular Chlamydia Infection in Tanzania	No drug interventions	prevention	4	completed
NCT00792922	Partnership for Rapid Elimination of Trachoma	Azithromycin	treatment	4	completed
NCT02176057	Nepal Elimination of Trachoma Study	Azithromycin	treatment	2 / 3	withdrawn
NCT01903057	Safety Study of Combined Azithromycin, Ivermectin and Albendazole for Trachoma and Lymphatic Filariasis	Albendazole Azithromycin Ivermectin	Not Available	4	withdrawn
NCT02373657	Water Uptake for Health in Amhara Pilot	No drug interventions	prevention	Not Available	completed
NCT04002726	App-based Versus Slide-based Inter-grader Agreement (IGA) Test for Trachoma Graders	No drug interventions	other	Not Available	terminated
NCT00286026	Azithromycin in Control of Trachoma II	Azithromycin	treatment	4	withdrawn
NCT00356720	Efficacy and Safety of 2 Dosing Regimens of T1225 Eye Drops 1.5% Versus Oral Azithromycin in Treatment of Trachoma	Azithromycin	treatment	3	completed
NCT00522860	A Trial of Non-absorbable Versus Absorbable Sutures for Trichiasis Surgery	No drug interventions	treatment	4	completed
NCT03676140	Safety of Co-administration of IDA and Azithromycin for NTDs ( ComboNTDs )	Albendazole Azithromycin Diethylcarbamazine Ivermectin	treatment	3	completed
NCT00322972	Trachoma Amelioration in Northern Amhara (TANA)	Azithromycin	treatment	4	completed
NCT03335072	Kebele Elimination of Trachoma for Ocular Health	Azithromycin	treatment	4	recruiting
NCT03813069	Testing Insect Repellents Against Musca Sorbens, the Vector of Trachoma	No drug interventions	prevention	2	completed