Duodenal Ulcer (DBCOND0000852)

Identifiers

Synonyms

Duodenal Ulcer，DU / Duodenal ulceration / Duodenal Ulcer (DU) / Duodenal Ulcers / Gastro-duodenal ulcer / Gastroduodenal Ulcers / Gastroduodenal Ulcer / Duodenal ulcer / Ulcer duodenal / Ulcer of duodenum (disorder) / Acute erosion of duodenum (disorder) / Ulcer gastroduodenal / Peptic ulcer, site unspecified / Peptic ulcer syndrome / Ulcer syndrome peptic / Peptic ulcer disease / Syndrome peptic ulcer / PUD / Peptic ulceration / GDU / Peptic ulcer / Peptic ulcer (disorder) / Ulcer peptic

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Aluminum hydroxide	An antacid used for the symptomatic relief of heartburn, acid indigestion, and sour stomach.	No drug targets
Bismuth subsalicylate	An antidiarrheal and anti-inflammatory agent used for symptomatic treatment of nausea, indigestion, upset stomach, diarrhea, and other temporary discomforts of the stomach and gastrointestinal tract.	Albumincarrier Serotransferrincarrier
Dexrabeprazole	A proton pump inhibitor indicated in the treatment of gastroesophageal reflux disease and gastrointestinal ulcers.	Cytochrome P450 2C19enzyme
Dimethicone	An ingredient used to treat dry and irritated eyes.	No drug targets
Esomeprazole	A proton pump inhibitor used to treat GERD, reduce the risk of NSAID associated gastric ulcers, eradicate H. pylori, and to treat conditions causing gastric acid hypersecretion.	Potassium-transporting ATPase alpha chain 1target Cytochrome P450 2C19enzyme Cytochrome P450 3A4enzyme N(G),N(G)-dimethylarginine dimethylaminohydrolase 1target ATP-dependent translocase ABCB1transporter Organic anion transporter 3transporter Potassium-transporting ATPase subunit betatarget
Famotidine	A histamine H2 receptor antagonist used to treat duodenal ulcers, benign gastric ulcers, GERD, and Zollinger-Ellison syndrome.	Histamine H2 receptortarget Solute carrier family 22 member 2transporter Organic anion transporter 3transporter Multidrug and toxin extrusion protein 1transporter Cytochrome P450 1A2enzyme Solute carrier family 22 member 6transporter
Lansoprazole	A proton pump inhibitor used to help gastrointestinal ulcers heal, to treat symptoms of gastroesophageal reflux disease (GERD), to eradicate Helicobacter pylori, and to treat hypersecretory conditions such as Zollinger-Ellison Syndrome.	Potassium-transporting ATPase alpha chain 1target Cytochrome P450 2C19enzyme Cytochrome P450 2C9enzyme Cytochrome P450 3A4enzyme ATP-dependent translocase ABCB1transporter Broad substrate specificity ATP-binding cassette transporter ABCG2transporter Cytochrome P450 1A1enzyme Cytochrome P450 1B1enzyme Cytochrome P450 2C18enzyme Cytochrome P450 2C8enzyme Cytochrome P450 2D6enzyme Microtubule-associated protein tautarget Organic anion transporter 3transporter Solute carrier family 22 member 1transporter Solute carrier family 22 member 2transporter Solute carrier family 22 member 3transporter
Metronidazole	A nitroimidazole used to treat trichomoniasis, amebiasis, inflammatory lesions of rosacea, and bacterial infections, as well as prevent postoperative infections.	Oxygen-insensitive NADPH nitroreductasetarget Cytochrome P450 2C9enzyme Cytochrome P450 3A4enzyme Cytochrome P450 2C8enzyme UDP-glucuronosyltransferase 1A1enzyme Anaerobic bacterial DNAtarget Protozoal DNAtarget ATP-dependent translocase ABCB1transporter Cytochrome P450 2A6enzyme Cytochrome P450 3A5enzyme Cytochrome P450 3A7enzyme
Nizatidine	An H2 receptor antagonist used to treat GERD and a variety of ulcers.	Histamine H2 receptortarget ATP-dependent translocase ABCB1transporter Cholinesteraseenzyme
Omeprazole	A proton pump inhibitor used to treat GERD associated conditions such as heartburn and gastric acid hypersecretion, and to promote healing of tissue damage and ulcers caused by gastric acid and H. pylori infection.	Potassium-transporting ATPase alpha chain 1target Cytochrome P450 2C19enzyme Cytochrome P450 3A4enzyme Cytochrome P450 2C9enzyme Cytochrome P450 1A2enzyme ATP-binding cassette sub-family C member 3transporter ATP-dependent translocase ABCB1transporter Broad substrate specificity ATP-binding cassette transporter ABCG2transporter Cytochrome P450 1A1enzyme Cytochrome P450 1B1enzyme Cytochrome P450 2C18enzyme Cytochrome P450 2C8enzyme Cytochrome P450 2D6enzyme Aryl hydrocarbon receptortarget Potassium-transporting ATPase subunit betatarget
Pantoprazole	A proton pump inhibitor used to treat erosive esophagitis, gastric acid hypersecretion, and to promote healing of tissue damage caused by gastric acid.	Potassium-transporting ATPase alpha chain 1target Cytochrome P450 2C19enzyme Cytochrome P450 3A4enzyme ATP-dependent translocase ABCB1transporter Broad substrate specificity ATP-binding cassette transporter ABCG2transporter Organic anion transporter 3transporter N(G),N(G)-dimethylarginine dimethylaminohydrolase 1target Potassium-transporting ATPase subunit betatarget
Pentagastrin	A gastrin-like molecule used as a diagnostic aid for the evaluation of gastric acid secretory function, gastric hypersecretion, and Zollinger-Ellison tumors.	Gastrin/cholecystokinin type B receptortarget Cholinesteraseenzyme
Rabeprazole	A proton pump inhibitor used to help gastrointestinal ulcers heal, to treat symptoms of gastroesophageal reflux disease (GERD), to eradicate Helicobacter pylori, and to treat hypersecretory conditions such as Zollinger-Ellison Syndrome.	Potassium-transporting ATPase alpha chain 1target Cytochrome P450 3A4enzyme Cytochrome P450 2C19enzyme Broad substrate specificity ATP-binding cassette transporter ABCG2transporter Cytochrome P450 1A1enzyme Cytochrome P450 1A2enzyme Cytochrome P450 2C9enzyme Cytochrome P450 2D6enzyme Cytochrome P450 2C8enzyme
Ranitidine	A histamine H2 antagonist used to treat duodenal ulcers, Zollinger-Ellison syndrome, gastric ulcers, GERD, and erosive esophagitis.	Histamine H2 receptortarget Cytochrome P450 1A2enzyme Cytochrome P450 2D6enzyme Solute carrier family 22 member 1transporter ATP-dependent translocase ABCB1transporter Organic anion transporter 3transporter Cytochrome P450 3A4enzyme Acetylcholinesterasetarget Solute carrier family 22 member 2transporter Acetylcholinesteraseenzyme
Sodium bicarbonate	A compound used for the symptomatic treatment of heartburn, acid indigestion, and upset stomach as well as the treatment of metabolic acidosis associated with conditions such as severe renal disease and circulatory insufficiency due to shock.	Electrogenic sodium bicarbonate cotransporter 1transporter Sodium bicarbonate cotransporter 3transporter Electroneutral sodium bicarbonate exchanger 1transporter Electrogenic sodium bicarbonate cotransporter 4transporter Hydrogen ionstarget Sodium-driven chloride bicarbonate exchangertransporter Voltage-dependent T-type calcium channel subunit alpha-1Htarget A-type voltage-gated potassium channel KCND3target
Sucralfate	A gastro-duodenal protective agent used in the treatment of gastric and duodenal ulcers and to prevent duodenal ulcer recurrence.	Fibrinogentarget Pepsin A-5target Pro-epidermal growth factortarget Fibroblast growth factor 2target
Vonoprazan	A potassium-competitive acid blocker used in the treatment of acid-related disorders and as an adjunct to Helicobacter pylori eradication.	Hydrogen potassium ATPasetarget Cytochrome P450 3A4enzyme Cytochrome P450 3A5enzyme Cytochrome P450 2B6enzyme Cytochrome P450 2C19enzyme Cytochrome P450 2C9enzyme Cytochrome P450 2D6enzyme ATP-dependent translocase ABCB1transporter Albumincarrier Alpha-1-acid glycoprotein 1carrier

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT04503629	A Phase 2 Randomised Controlled Trial to Evaluate Efficacy and Safety of Anaprazole in Patients With Duodenal Ulcers.	Rabeprazole	treatment	2	completed
NCT04215653	A Phase 3 Randomised Controlled Trial to Evaluate Efficacy and Safety of Anaprazole in Patients With Duodenal Ulcers.	Rabeprazole	treatment	3	unknown_status
NCT02423187	Rabeprazole Specific Clinical Experience Investigation for the Long-term Combination Therapy With Low-dose Aspirin	No drug interventions	Not Available	Not Available	completed
NCT05010954	Efficacy and Safety of LXI-15028 Comparing With Lansoprazole in the Treatment of Duodenal Ulcer	Lansoprazole Tegoprazan	treatment	3	completed
NCT01562600	Nexium Capsules Non-steroidal Anti-inflammatory Drug (NSAID) Specific Clinical Experience Investigation	No drug interventions	Not Available	Not Available	completed
NCT00762359	A Safety and Efficacy Study of Lansoprazole in Preventing Aspirin-Induced Gastric and Duodenal Ulcers	Gefarnate Lansoprazole	treatment	3	terminated
NCT00197470	Cytokine Gene Polymorphisms in Gastric Diseases	No drug interventions	diagnostic	Not Available	unknown_status
NCT04702542	To Develop Methods for the Rehabilitation of Chronic Gastroduodenal Pathology in Children.	No drug interventions	supportive_care	Not Available	active_not_recruiting
NCT01452724	Efficacy and Safety of TAK-438 Compared to AG-1749 (Lansoprazole) in the Treatment of Duodenal Ulcer	Lansoprazole Vonoprazan	treatment	3	completed
NCT03553563	A Study of Esomeplazole (D961H) in Japanese Paediatric Patients With Reflux Esophagitis, Gastric Ulcer or Duodenal Ulcer	Esomeprazole	prevention	3	completed
NCT01435525	Nexium Capsules Helicobacter Pylori Specific Clinical Experience Investigation	No drug interventions	Not Available	Not Available	completed
NCT01964131	BE Study Between a Capsule and a Sachet Formulation of D961H by Pharmacodynamics in Japanese Healthy Male Subjects	No drug interventions	basic_science	1	completed
NCT02847455	Ilaprazole for the Treatment of Duodenal Ulcer in Chinese Patients	Ilaprazole Rabeprazole	treatment	2 / 3	completed
NCT00149084	Tailored Treatment of H. Pylori Infection Based Polymorphisms of CYP2C19 and 23S rRNA of H. Pylori	Amoxicillin Clarithromycin Lansoprazole	treatment	3	unknown_status
NCT00787254	Efficacy and Safety of Lansoprazole on Gastric and Duodenal Ulcers in Patients Taking Nonsteroidal Anti-Inflammatory Drugs	Gefarnate Lansoprazole	treatment	3	completed
NCT00854451	Relation of Metabolic Rate of Omeprazole and Eradication of Helicobacter Pylori Infection	Amoxicillin Omeprazole	treatment	4	completed
NCT00173953	Lymphocytic Subsets and Cytokine Production With H. Pylori Infection	No drug interventions	diagnostic	Not Available	completed
NCT01568398	A Unblinded Study of TAK-438 (20 mg) for Prevention of Recurrence of Gastric or Duodenal Ulcer During Long-Term Low-Dose Aspirin Therapy	Vonoprazan	treatment	3	completed
NCT00132171	Helicobacter Pylori Eradication With a New Sequential Treatment	No drug interventions	treatment	3	completed
NCT03057171	A Study on the Gastrointestinal Disease and Helicobacter Pylori Controlled Long Non-coding RNA	No drug interventions	Not Available	Not Available	unknown_status
NCT00952978	Ilaprazole for the Treatment of Duodenal Ulcer in Chinese Patients (Phase 3)	Ilaprazole Omeprazole	treatment	3	completed
NCT01568385	A Unblinded Study of TAK-438 (20 mg) for Prevention of Recurrence of Gastric or Duodenal Ulcer During Long-Term Non-Steroid Anti-Inflammatory Drug (NSAID) Therapy	Vonoprazan	treatment	3	completed
NCT03050359	Comparison of TAK-438 (Vonoprazan) to Lansoprazole in the Treatment of Duodenal Ulcer Participants With or Without Helicobacter Pylori Infection	Lansoprazole Vonoprazan	treatment	3	completed
NCT01199536	Helicobacter Pylori Eradication Treatment in Patients With Duodenal Ulcers	No drug interventions	Not Available	Not Available	completed
NCT00197418	Second Line Therapy for the Cure of Helicobacter Pylori (H. Pylori) Infection	Amoxicillin Clarithromycin Metronidazole Rabeprazole	treatment	2 / 3	unknown_status
NCT00595517	Long Term Study to Investigate the Efficacy & Safety of D961H (Esomeprazole) for the Prevention of NSAIDs-induced Ulcer	Esomeprazole	prevention	3	completed
NCT01729182	Nexium Capsules LDA Specific Clinical Experience Investigation	No drug interventions	Not Available	Not Available	completed
NCT00441727	Study of Esomeprazole 20 mg or 40 mg vs Placebo Effectiveness on the Occurrence of Peptic Ulcers in Subjects on Low Dose Acetylsalicylic Acid (LDA)	Esomeprazole	prevention	3	completed
NCT01037491	Comparison of Ulcer Healing in Patients Taking Rabeprazole With Different Antiplatelets	Acetylsalicylic acid Clopidogrel Rabeprazole	treatment	Not Available	unknown_status
NCT00542789	Comparative Efficacy & Safety Study of Esomeprazole Versus Placebo for the Prevention of Gastric and Duodenal Ulcers With NSAID	Esomeprazole	prevention	3	completed
NCT05579444	Systems Biology of Gastrointestinal and Related Diseases	No drug interventions	Not Available	Not Available	terminated
NCT00543868	MK0782 + Low-Dose Aspirin 7-Day Erosion Endoscopy Study (0782-001)	No drug interventions	prevention	2	completed
NCT05208268	A Study of Pariet to Prevent Gastric and Duodenal Ulcer Associated With Low-aspirin in Korean Participants With a History of Gastric and Duodenal Ulcer	Rabeprazole	Not Available	Not Available	completed
NCT00953381	Ilaprazole for the Treatment of Duodenal Ulcer in Chinese Patients (Phase 2)	Ilaprazole Omeprazole	treatment	2	completed
NCT00284908	Dose-Effect of S-Tenatoprazole-Na(STU-Na) 30 mg, 60 mg, 90 mg and 120 mg in Healthy Volunteers	No drug interventions	treatment	1	completed
NCT02153398	A Phase I/III Study of D961H 10 mg and 20 mg in Japanese Paediatric Patients With Gastrointestinal Acid Related Diseases	No drug interventions	treatment	3	completed
NCT01452763	Efficacy and Safety of TAK-438 for the Prevention of Recurrent Gastric or Duodenal Ulcers During Therapy of Low-dose Aspirin	Lansoprazole Vonoprazan	prevention	3	completed
NCT01456247	Long-term Extension Study of TAK-438 for the Prevention of Recurrent Gastric or Duodenal Ulcers During Therapy of Low-dose Aspirin	Lansoprazole Vonoprazan	prevention	3	completed
NCT01456260	Long-term Extension Study of TAK-438 for the Prevention of Recurrent Gastric or Duodenal Ulcers During Therapy of Non-steroidal Anti-inflammatory Drug (NSAID)	Lansoprazole Vonoprazan	prevention	3	completed
NCT01452750	Efficacy and Safety of TAK-438 for the Prevention of Recurrent Gastric or Duodenal Ulcers During Therapy of Non-steroidal Anti-inflammatory Drug (NSAID)	Lansoprazole Vonoprazan	prevention	3	completed
NCT00613665	Safety and Immunogenicity of Chiron's Investigational H. Pylori Vaccine in Healthy Adults	No drug interventions	prevention	1	completed
NCT02882477	Treatment of Wolfram Syndrome Type 2 With the Chelator Deferiprone and Incretin Based Therapy	Acetylcysteine Deferiprone Metformin Sitagliptin	treatment	2 / 3	unknown_status
NCT00778193	Effect of Naproxen, Aspirin, Celecoxib, or Clopidogrel on the Healing of Stomach and Intestinal Ulcers	Acetylsalicylic acid Celecoxib Clopidogrel Naproxen	Not Available	4	completed
NCT06393907	Hemostatic Forceps vs. Bipolar Electrocautery Probes for High-Risk Bleeding Gastroduodenal Ulcers	No drug interventions	treatment	Not Available	recruiting
NCT02175186	Effect of ALBIS on Gastroduodenal Mucosal Injury in Patients Receiving Dual Antiplatelet Therapy After Percutaneous Coronary Intervention	No drug interventions	treatment	4	completed
NCT02724150	Comparison of Low Against High Regimen of Proton Pump Inhibitors for Treatment of Acute Peptic Ulcer Bleeding	Omeprazole	treatment	4	withdrawn
NCT04123899	BE Study of Gaster®D Tab 20mg (Manufacturer Changed)	No drug interventions	treatment	Not Available	unknown_status
NCT03163680	Efficacy of Low Dose of Proton Pump Inhibitor in Treatment Bleeding Ulcers	Omeprazole	Not Available	Not Available	completed